The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans

Acta Anaesthesiologica Scandinavica

Volumn 42, Issue 7, 1998, Pages 750-758

  Persson, J ^a   Hasselstrom J ^a   Wiklund, B ^a   Heller, A ^a   Svensson, J O ^a   Gustafsson, L L ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Arterial occlusive diseases; Ischemia; Ketamine; Morphine; NMDA antagonist; Opioids; Pain

Indexed keywords

BUPRENORPHINE; KETAMINE; KETOBEMIDONE; MORPHINE;

ADULT; AGED; ANALGESIA; ANALGESIC ACTIVITY; ARTICLE; CHRONIC PAIN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LEG; MALE; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VISUAL HALLUCINATION;

EID: 0031853643     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-6576.1998.tb05317.x     Document Type: Article

References (40)

1. Bonica JJ. Pain due to vascular disease. In: Bonica JJ, ed. The Management of Pain. Philadelphia: Lea & Febiger, 1990: 508.
2. Tyrrell MR, Wolfe JHM, for the joint vascular research group (JVRG). Critical leg ischaemia: An appraisal of clinical definitions. Br J Surg 1993: 80: 177-180.
3. Mense S. Nociception from skeletal muscle in relation to clinical muscle pain. Pain 1993: 54: 241-289.
4. Mense S, Stahnke M. Responses in muscle afferent fibres of slow conduction velocity to contractions and ischemia in the cat. J Physiol (Lond) 1983: 342: 383-397.
5. Mills KR. Newham DJ, Edwards RHT. Muscle pain. In: Wall PD, Melzack R, eds. Textbook of Pain. Edinburgh: Churchill Livingstone, 1989: 420-432.
6. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993: 52: 259-285.
7. Woolf CJ, Thompson WN. The induction and maintenance of central sensitisation is dependent on N-methyl-D-aspartaric acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain 1991: 44: 293-299.
8. Dickenson AH. A cure for wind up: NMDA receptor antagonists as potential analgesics. TIPS 1990: 11: 307-309.
9. Persson J, Axelsson G, Hallin RG, Gustafsson LL. Beneficial effects of ketamine in a chronic pain state with allodynia, possibly due to central sensitization. Pain 1995: 60: 217-222.
10. Maurset A, Skoglund LA, Hustveit O, Øye I. Comparison of ketamine and pethidine in experimental and postoperative pain. Pain 1989: 36: 37-41.
11. Klepstad P, Maurset A, Moberg ER, Øye I. Evidence of a role for NMDA receptors in pain perception. Eur J Pharmacol 1990: 187: 513-518.
12. Segerdahl M, Ekblom A, Sollevi A. The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers. Anesth Analg 1994: 79: 787-791.
13. Svensson JO, Gustafsson LL. Determination of ketamine and norketamine enantiomeres in plasma by solid phase extraction and high performance liquid chromatography. J Chromatogr B Biomed Appl 1996: 678: 373-376.
14. Huskisson EC. Visual analogue scales. In: Melzack R, ed. Pain measurement and assessment. New York: Raven Press, 1983: 33-37.
15. Siegel S, Castellan NJ. Nonparametric statistics for the behaviorial sciences. New York: McGraw-Hill international editions, 1988: 174-183.
16. Menard S. Applied logistic regression analysis. London: Sage university papers, Sage publications, 1995.
17. White PF, Schüttler J, Shafer A, Stanski DR, Horai Y, Trevor AJ. Comparative pharmacology of the ketamine isomers. Br J Anaesth 1985: 57: 197-203.
18. Øye I, Hustveit O, Maurset A, Ratti-Moberg E, Paulsen O, Skoglund LA. The chiral forms of ketamine as probes for NMDA receptor functions in humans. In: Kameyana T, Nabeshima T, Domino EF. eds. NMDA Receptor Related Agents: Biochemistry, Pharmacology and Behaviour. Ann Arbor: NPP Books, 1990: 381-389.
19. Backonja M, Arndt G, Gombar KA, Check B, Zimmerman M. Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. Pain 1994: 56: 51-57.
20. Bovill JG, Dundee JW. Alterations in response to somatic pain associated with anaesthesia. Br J Anaesth 1971: 34: 496-498.
21. Dich-Nielsen JO, Svendsen LB, Berthelsen P. Intramuscular low-dose ketamine versus pethidine for postoperative pain treatment after thoracic surgery. Acta Anaesthesiol Scand 1992: 36: 583-587.
22. Joachimsson P-O, Hedstrand U, Eklund A. Low-dose ketamine infusion for analgesia during postoperative ventilator treatment. Acta Anaesthesiol Scand 1986: 30: 697-702.
23. Mathisen LC, Skjelbred P, Skoglund LA, Oye I. Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain. Pain 1995: 61: 215-220.
24. Eide PK, Stubhaug A, Öye I, Breivik H. Continuous subcutaneous administration of the N-methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia. Pain 1995: 61: 221-228.
25. Bjune K, Stubhaug A, Dodgson MS, Breivik H. Additive analgesic effect of codeine and paracetamol can be detected in strong, but not moderate, pain after Caesarean section. Baseline pain-intensity is a determinant of assay-sensitivity in a postoperative analgesic trial. Acta Anaesthesiol Scand 1996: 40: 399-407.
26. Clements JA, Nimmo WS, Grant IS. Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans. J Pharm Sci 1982: 71: 539-542.
27. Schüttler J, Stanski DR, White PF, Trevor AJ, Horai Y, Verotta D et al. Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man. J Pharm Biopharm 1987: 15: 241-253.
28. Reich DL, Silvay, G. Ketamine. An update on the first twenty-five years of clinical experience. Can J Anaesth 1989: 36: 186-197.
29. Cabbabe EB, Behbahani PM. Cardiovascular reactions associated with the use of ketamine and epinephrine in plastic surgery. Ann Plast Surg 1985: 15: 50-56.
30. Ivankovich AD, Miletich DJ, Reimann C, Albrecht RF, Zahed B. Cardiovascular effects of centrally administered ketamine in goats. Current Researches in Anesthesia and Analgesia 1974: 53: 924-933.
31. Mayumi T, Dohi S, Takahashi T. Cardiovascular effects of ketamine in humans with cervical or lumbar epidural blockade. Anesthesiology 1985: 62: 39-43.
32. White PF. Comparative evaluation of intravenous agents for rapid sequence induction - thiopental, ketamine and midazolam. Anesthesiology 1982: 57: 279-184.
33. Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Arch Gen Phychiatry 1994: 51: 199-214.
34. Hartvig P, Valtysson J, Lindner K-J, Kristenssen J, Karlsten R, Gustafsson LL et al. Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers. Clin Pharmacol Ther 1995: 58: 165-173.
35. Bålfors E, Häggmark S, Nyhman H, Rydvall A, Reiz S. Droperidol inhibits the effects of intravenous ketamine on central hemodynamics and myocardial oxygen consumption in patients with generalized atherosclerotic disease. Anesth Analg 1983: 62: 193-197.
36. Cartwright PD, Pingel SM. Midazolam and diazepam in ketamine anaesthesia. Anaesthesia 1984: 39: 439-442.
37. Chapman V, Dickenson AH. The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn. Brain Res 1992: 573: 321-323.
38. Bristow A, Orlikowski C. Subcutaneous ketamine analgesia: Postoperative analgesia using subcutaneous infusion of ketamine and morphine. Ann R Coll Surg Engl 1989: 71: 64-66.
39. Cherry D, A, Plummer JL, Gourlay GK, Coates KR, Odgers CL. Ketamine as an adjunct to morphine in the treatment of pain. Pain 1995: 62: 119-121.
40. Schüttler J. S-(+)-Ketamine. Anaesthesist 1992: 41: 585-587.