Two-locus developments of the weighted pairwise correlation method for linkage analysis

Genetic Epidemiology

Volumn 15, Issue 5, 1998, Pages 491-510

  Zinn Justin, Anne ^a   Abel, Laurent ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Linkage analysis; Nonparametric method; Simulation studies; Two locus analysis; WPC approach

Indexed keywords

ARTICLE; GENE FREQUENCY; GENE LOCATION; GENE MAPPING; GENETIC ANALYSIS; GENETIC LINKAGE; PHENOTYPE; STATISTICAL ANALYSIS;

ALLELES; GENETIC MARKERS; GENOTYPE; HUMANS; LINKAGE (GENETICS); MODELS, GENETIC;

EID: 0031853198     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1998)15:5<491::AID-GEPI4>3.0.CO;2-3     Document Type: Article

References (12)

1. Commenges D (1994): Robust genetic linkage analysis based on a score test of homogeneity: The weighted pairwise correlation statistic. Genet Epidemiol 11:189-200.
2. Commenges D, Abel L (1996): Improving the robustness of the weighted pairwise correlation test for linkage analysis. Genet Epidemiol 13:559-573.
3. Commenges D, Jacqmin-Gadda H (1997): Generalized score test of homogeneity based on correlated random effects models. J R Stat Soc B 59:157-171.
4. Commenges D, Beurton-Aimar M (1997): WPC test based on randomisation for analysing quantitative traits on simulated pedigrees. Genet Epidemiol (in press).
5. Cordell HJ, Todd JA, Benett ST, Kawagushi Y, Farrall M (1995): Two-locus maximum lod score analysis of a multifactorial trait: Joint consideration of IDDM2 and IDDM4 with IDDM1 in type I diabetes. Am J Hum Genet 57:920-934.
6. Dizier MH, Clerget-Darpoux F (1986): Two-disease locus model: Sib pair method using information of both HLA and Gm. Genet Epidemiol 3:343-356.
7. 2 method. Am J Hum Genet 55:1042-1049.
8. Knapp M, Seuchter SA, Baur MP (1994): Two-locus disease models with two marker loci: The power of affected-sib-pair tests. Am J Hum Genet 55:1030-1041.
9. Risch N (1990a): Linkage strategies for genetically complex traits: I. Multilocus models. Am J Hum Genet 46:222-228.
10. Risch N (1990b): Linkage strategies for genetically complex traits: III. The effect of marker polymorphism on analysis of affected relative pairs. Am J Hum Genet 46:242-253.
11. Schork NJ, Boehnke M, Terwilliger JD, Ott J (1993): Two-trait locus linkage analysis: A powerful strategy for mapping complex genetic traits. Am J Hum Genet 53:1127-1136.
12. Speer MC, Terwilliger JD, Ott J (1995): Data simulation for GAW 9 problems 1 and 2. Genet Epidemiol 12:561-564.