Selection and analysis of rare second-site suppressors of Drosophila RNA polymerase II mutations

Molecular and General Genetics

Volumn 258, Issue 5, 1998, Pages 457-465

  Krasnoselskaya, I ^a   Huang, J ^a,b   Jones, T ^a   Dezan, C ^a   Mortin, M A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Adaptive mutation; Drosophila melanogaster; Mutagenesis; RNA polymerase II; Suppressor selection

Indexed keywords

RNA POLYMERASE II;

ALLELE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME SUBUNIT; EUKARYOTIC CELL; GENE LOCUS; GENE MUTATION; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SUPPRESSOR GENE;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; DROSOPHILA MELANOGASTER; MOLECULAR SEQUENCE DATA; MUTAGENESIS; POINT MUTATION; RNA POLYMERASE II; SUPPRESSION, GENETIC;

ANIMALIA; DROSOPHILA MELANOGASTER; EUKARYOTA; MELANOGASTER;

EID: 0031852855     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050756     Document Type: Article

References (35)

1. Barolomei MS, Corden JL (1987) Localization of an α-amanitin resistant mutation in the gene encoding the largest subunit of mouse RNA polymerase II. Mol Cell Biol 7:586-594
2. Biggs J, Searles LL, Greenleaf AL (1985) Structure of the eukaryotic transcription apparatus: features of the gene for the largest subunit of Drosophila RNA polymerase II. Cell 42:611-621
3. Cairns J, Overgaugh J, Miller S (1988) The origin of mutants. Nature 335:141-145
4. Chen Y, Weeks J, Mortin MA, Greenleaf AL (1993) Mapping mutations in genes encoding the two largest subunits of Drosophila RNA polymerase II defines domains essential for basic transcription functions and for proper expression of developmental genes. Mol Cell Biol 13:4214-4222
5. Darst SA, Kubalek EW, Kornberg RD (1989) Three-dimensional structure of Escherichia coli RNA polymerase holoenzyme determined by electron crystallography. Nature 340:730-732
6. Darst SA, Edwards AM, Kubalek EW, Kornberg RD (1991) Three-dimensional structure of yeast RNA polymerase II at 16Å resolution. Cell 66:121-128
7. Fortini M, Artavanis-Tsakonas S (1994) The Suppressor of Hairless protein participates in Notch receptor signaling. Cell 79:273-282
8. Galitski T, Roth JR (1995) Evidence that F plasmid transfer replication underlies apparent adaptive mutation. Science 268:421-423
9. Greenleaf AL (1983) Amanitin-resistant RNA polymerase II mutations are in the enzyme's largest subunit. J Biol Chem 258:13403-13406
10. Greenleaf AL, Borsett LM, Jiamachello PF, Coulter DE (1979) α-amanitin-resistant D. melanogaster with an altered RNA polymerase II. Cell 18:613-622
11. Greenleaf AL, Weeks JR, Voelker RA, Ohnishi S, Dickson B (1980) Genetic and biochemical characterization of mutants at an RNA polymerase II locus in D. melanogaster. Cell 21:785-792
12. Hamilton BJ, Mortin MA, Greenleaf AL (1993) Reverse genetics of Drosophila RNA polymerase II: identification and characterization of RpII140, the genomic locus for the second-largest subunit. Genetics 134:517-529
13. Harris RS, Longerich S, Rosenberg SM (1994) Recombination in adaptive mutation. Science 264:258-260
14. Jarvik J, Botstein D (1975) Conditional-lethal mutations that suppress genetic defects in morphogenesis by altering structural proteins. Proc Natl Acad Sci USA 72:2738-2742
15. Kim WJ, Burke LP, Mortin MA (1994) Molecular modeling of RNA polymerase II mutations onto DNA polymerase I. J Mol Biol 244:13-22
16. Lefevre G Jr (1971) Salivary chromosome bands and the frequency of crossing over in Drosophila melanogaster. Genetics 67:497-513
17. Lefevre G Jr, Watkins W (1985) The question of the total gene number in Drosophila melanogaster. Genetics 113:869-895
18. Lindsley DL, GG Zimm (1992) The genome of Drosophila melanogaster. Academic Press, San Diego, Calif
19. Mann C, Buhler J-M, Treich I, Sentenac A (1987) RPC40, a unique gene for a subunit shared between yeast RNA polymerases A and C. Cell 48:627-637
20. Miller JH (1992) A short course in bacterial genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
21. Mortin MA (1990) Use of second-site suppressor mutations in Drosophila to identify components of the transcriptional machinery. Proc Natl Acad Sci USA 87:4864-4868
22. Mortin MA, Kaufman TC (1982) Developmental genetics of a temperature-sensitive RNA polymerase II mutation in Drosophila melanogaster. Mol Gen Genet 187:120-125
23. Mortin MA, Kaufman TC (1984) Developmental effects of a temperature-sensitive RNA polymerase II mutations in Drosophila melanogaster. Dev Biol 103:343-354
24. Mortin MA, Lefevre G Jr (1981) An RNA polymerase II mutation in Drosophila melanogaster that mimics Ultrabithorax. Chromosoma 82:237-247
25. Mortin MA, Kim WJ, Huang J (1988) Antagonistic interactions between alleles of the RpII215 Locus in Drosophila melanogaster. Genetics 119:863-873
26. Mortin MA, Zuerner R, Berger S, Hamilton BJ (1992) Mutations in the second-largest subunit of Drosophila RNA polymerase II interact with Ubx. Genetics 131:895-903
27. Ollis DL, Brick P, Hamlin R, Xuong NG, Steitz TA (1985a) Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP. Nature 313:762-766
28. Ollis DL, Kline C, Steitz TA (1985b) Domain of E. coli DNA polymerase I showing sequence homology to T7 DNA polymerase. Nature 313:818-819
29. Radicella JP, Park PU, Fox MS (1995) Adaptive mutation in Escherichia coli: a role for conjugation. Science 268:418-420
30. Schultz P, Celia H, Riva M, Bautz EKF (1993) Three-dimensional model of yeast RNA polymerase I determined by electron microscopy of two-dimensional crystals. EMBO J 12:2601-2607
31. Sentenac A (1985) Eukaryotic RNA polymerases. CRC Crit Rev Biochem 18:31-91
32. Sousa R, Chung YJ, Rose JP, Wang B-C (1993) Crystal structure of bacteriophage T7 RNA polymerase at 3.3 Å resolution. Nature 364:593-599
33. Voelker RA, Wisely GB, Huang S-M, Gyurikovics H (1985) Genetic and molecular variation in the RpII215 region of Drosophila melanogaster. Mol Gen Genet 201:437-445
34. Woychik NA, Liao S-M, Kolodziej PA, Young RA (1990) Subunits shared by eukaryotic nuclear RNA polymerases. Genes Dev 4:313-323
35. Young RA (1991) RNA polymerase II. Annu Rev Biochem 60:689-715