Bioactive conformations of ligands for the calcium channel α2δ gabapentin binding site

Medicinal Chemistry Research

Volumn 8, Issue 3, 1998, Pages 153-162

  Bryans, Justin S ^a   Horwell, David C ^a   McGuffog, Jane ^a   Morrell, Andrew I ^a   O'Niell, Jacqueline A ^a   Ratcliffe, Giles S ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL AFFECTING AGENT; GABAPENTIN; GABAPENTIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CALCIUM TRANSPORT; DRUG RECEPTOR BINDING; ENZYME SUBUNIT; LIGAND BINDING; NONHUMAN; PROTEIN CONFORMATION; RECEPTOR AFFINITY; STEREOCHEMISTRY;

EID: 0031852530     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Taylor, C.P. In New Trends in Epilepsy Management: The Role of gabapentin; Chadwick, D., Ed.; Royal Society of Medicine services Ltd: London, 1993; pp13-40.
2. Gee, N.S., Webdale, L., Hill, D.R., Woodruff, G.N., Eur. J. Pharmacol., 244, 293-301, 1993.
3. 3-Alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents. Taylor, C.P. Vartanian, M.G., Andruszkiewicz, R., Silverman, RB. Epilepsy Res., 11, 103-111, 1992.
4. Investigation into the prefered conformation of gabapentin for interaction with its binding site on the α2δ subunit of a calcium channel. Bryans, J.S., Davis, N., Gee, N.S, Horwell, D.C., Kneen, C.O., Morrell, A.I., O'Niell, J.A., Ratcliffe, G.S. Bioorg. Chem. Lett. 7 (19), 2481-2484, 1997.
5. Gee, N.S., Brown, J.P., Dissanayake, V.U.K., Offord, J., Woodruff, G.N. J. Biol. Chem. 271, 5768-5776, 1996.
6. Sybyl 6.3 supplied by Tripos Associates of 1699 South Hanley Road, Suite 303, St. Louis, Missouri 63144, USA.