Hepatocyte growth factor/scatter factor and its receptor c-met are overexpressed and associated with an increased microvessel density in malignant pleural mesothelioma

Journal of Cancer Research and Clinical Oncology

Volumn 124, Issue 6, 1998, Pages 291-296

  Tolnay, Edina ^a   Kuhnen, Cornelius ^b   Wiethege, Thorsten ^b   König, Jens Eckehard ^b   Voss, Bruno ^c   Müller, Klaus Michael ^b  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c Prof Associations' Res Inst O   (Germany)

Author keywords

Angiogenesis; Autocrine loop; C Met receptor; HGF SF; Malignant mesothelioma

Indexed keywords

SCATTER FACTOR;

ANGIOGENESIS; ARTICLE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROVASCULATURE; NEOVASCULARIZATION (PATHOLOGY); PLEURA MESOTHELIOMA; PRIORITY JOURNAL; TUMOR GROWTH;

HEPATOCYTE GROWTH FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MESOTHELIOMA; NEOVASCULARIZATION, PATHOLOGIC; PLEURAL NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MET;

EID: 0031852222     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050171     Document Type: Article

References (26)

1. Dean M, O'Connell P, Leppert M, et al. (1987) Three Additional DNA polymorphisms in the met gene and D7S8 locus: use in prenatal diagnosis of fibrosis. J Paediatr 111:490-495
2. Di Renzo MF, Narsimhan RP, Olivero M, et al. (1991) Expression of the MET-HGF receptor in normal and neoplastic human tissues. Oncogene 6:1997-2003
3. Folkman J, Watson K, Ingber D, Hanahan D (1989) Induction of anaiogenesis during the transition from hyperplasia to neoplasia. Nature 339:58-61
4. Grant DS, Kleinman HK, Goldberg ID, et al. (1993) Scatter factor induces blood vessel formation in vivo. Proc Natl Acad Sci USA 90:1937 1941
5. Jones JSP, Brachet EA, Butler EB (1987) The pleura and its pathology. In: Jones JSP (ed) Pathology of the mesothelium. Springer, London Berlin Heidelberg, pp 39-133
6. Klominek J, Baskin B, Hauzenberger M (1997) Platelet derived growth factor (PDGF) and hepatocyte growth factor (HGF) are chemoattractants for human malignant mesothelioma cells. Am J Respir Crit Care Med 155:A740
7. Lee TC, Zhang Y, Aston C, et al. (1993) Normal human mesothelial cells and mesothelioma cell lines express insuline-like growth factor I and associated molecules. Cancer Res 53:2858-2864
8. Müller K-M (1994) Erkrankungen der Pleura pathologische Anatomie. In: Nakhosteen JA, Inderbitzi R (eds) Atlas und Lehrbuch der thorakalen Endoskopie. Springer, Berlin Heidelberg New York, pp 325-339
9. Nakamura T, Nishizawa T, Hagiya M, et al. (1989) Molecular cloning and expression of human hepatocyte growth factor. Nature 342:440-443
10. Prewitt TW, Chaudhri G, Pass H (1993) Asbestos and interferon gamma synergistically induce murine macrophages to produce nitric oxide. Proc Am Assoc Cancer Res 34:445
11. Rom WN, Travis WD, Brody AR (1991) Cellular and molecular basis of the asbestos-related diseases. Am Rev Resp Dis 143:408-422
12. Rong S, Jeffers M, Resau J, Tsarfaty I, Oskarsson M, Vande Woude GF (1993) Met expression and sarcoma tumorigenicity. Cancer Res 53:5355-5360
13. Rong S, Segal S, Anver M, Resau JH, Vande Woude GF (1994) Invasiveness and metastasis of NIH 3T3 cells induced by Methepatocyte growth factor/scatter factor autocrine stimulation. Proc Natl Acad Sci USA 91:4731-4735
14. Rosen EM, Goldberg ID (1995) Scatter factor and angiogenesis. Adv Cancer Res 67:257-279
15. Schmidt C, Bladt F, Goedecke S, et al. (1995) Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373:699-702
16. Stanton MF, Layard M, Tegeris A, et al. (1981) Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J Natl Cancer Inst 67:965-975
17. Takayama H, LaRochelle WJ, Anver M, Bockman DE, Merlino G (1996) Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc Natl Acad Sci USA 93:5866-5871
18. Takayama H, LaRochelle WJ, Sharp R, et al. (1997) Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Proc Natl Acad Sci USA 94:701-706
19. Tsarfaty I, Resau JH, Rulong S, Keydar I, Faletto DL, Vande Woude GF (1992) The met proto-oncogene receptor and lumen formation. Science 257:1258-1261
20. Tsarfaty I, Rong S, Resau JH, Rulong S, Pinto da Silva P, Vande Woude GF (1994) The met proto-oncogene mediated signalling in mesenchymal to epithelial cell conversion. Science 263:98-101
21. Versnel MA, Claesson-Welsh L, Hammacher A, et al. (1991) Human malignant mesothelioma cell lines express PDGF β-receptors whereas cultured normal mesothelial cells express predominantly PDGF α-receptors. Oncogene 6:2005-2011
22. Weidner N (1995) Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 147:9-19
23. Weidner KM, Arakaki N, Hartmann G, et al. (1991) Evidence for the identity of human scatter factor and hepatocyte growth factor. Proc Natl Acad Sci USA 88:7001-7005
24. Wiethege T, Voss B, Pohle T, Fisseler-Eckhoff A, Müller KM. Localisation of elates and tumour necrosis factor alpha mRNA by non-radioactive in situ hybridisation in cultures of alveolar macrophages. Pathol Roes Precept 187:912-915
25. World Health Organisation (1981) International histological classifications of tumours. 1. Histological typing of lung tumours, 2nd ed. WHO, Geneva
26. Yanagita K, Matsumoto K, Sekiguchi K, Ishibashi H, Niho Y, Nakamura T (1993) Hepatocyte growth factor may act as a pulmotrophic factor on lung generation after acute lung injury, J Biol Chem 268:21212-21217