Are symptoms the most important target for therapy in chronic heart failure?

Progress in Cardiovascular Diseases

Volumn 41, Issue 1 SUPPL., 1998, Pages 59-64

  Cleland, J G F ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CARVEDILOL; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; NITRATE; WARFARIN;

DRUG EFFECT; ENZYME INHIBITION; HEART FAILURE; HOSPITALIZATION; HUMAN; PATIENT COMPLIANCE; PROGNOSIS; QUALITY OF LIFE; REVIEW; SYMPTOMATOLOGY;

EID: 0031852195     PISSN: 00330620     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0033-0620(98)80032-7     Document Type: Article

References (26)

1. Stewart AL Greenfield S Hays RD Functional status and well being of patients with chronic conditions: Results from the medical outcomes study JAMA 262 1989 907 913
2. Fryback DG Dasbach EJ Klein R The Beaver Dam health outcomes study: Initial catalog of healthstate quality factors Med Decis Making 13 1993 89 102
3. Loh E Sutton MS Wun CC Ventricular dysfunction and the risk of stroke after myocardial infarction N Engl J Med 336 1997 251 257
4. Yusuf S Pepine CJ Garces C Effect of enalapril on myocardial infarction and unstable angina in patients with low ejection fractions Lancet 340 1992 1173 1178
5. Cleland JGF McMurray J Cowburn PJ Heart Failure: A Systematic Approach for Clinical Practice 1997 Science Press London, UK
6. Northridge D Frusemide or nitrates for acute heart failure? Lancet 347 1996 667 668
7. Swedberg K Idanpaan Heikkila U Remes J Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study(CONSENSUS) N Engl J Med 316 1987 1429 1435
8. Yusuf S Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure N Engl J Med 325 1991 293 302
9. Yusuf S Nicklas JM Timmis G Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions N Engl J Med 327 1992 685 691
10. Narang R Swedberg K Cleland JGF What is the ideal study design for evaluation of treatment for heart failure? Insights from trials assessing the effects of ACE inhibitors onexercise capacity Eur Heart J 17 1996 120 134
11. Cleland JGF ACE inhibitors for the prevention and treatment of heart failure: Why are they ‘under-used’? J Hum Hypertens 9 1995 435 442
12. Bulpitt CJ Fletcher AE Measurement of the quality of life in congestive heart failure—Influence of drug therapy Cardiovasc Drugs Ther 2 1988 419 424
13. on behalf of the ELITE study group Pitt B Segal R Martinez FA Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan In The Elderly Study [ELITE]) Lancet 349 1997 747 752
14. Cleland JGF Bristow M Erdmann E Betablocking agents in heart failure. Should they be used and how? Eur Heart J 17 1996 1629 1639
15. Lechat P Jaillon P Fontaine ML A randomized trial of beta-blockade in heart failure: The Cardiac Insufficiency Bisoprolol Study (CIBIS) Circulation 90 1994 1765 1773
16. Waagstein F Bristow MR Swedberg K Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy Lancet 342 1993 1441 1446
17. Metra M Nardi M Giubbini R Effects of short- and long-term carvedilol administration on rest and exercise hemodynamic variables, exercise capacity and clinical conditions in patients with idiopathic dilated cardiomyopathy J Am Coll Cardiol 24 1994 1678 1687
18. Packer M Bristow MR Cohn JN The effect of carvedilol on morbidity and mortality in patients with chronic heart failure N Engl J Med 334 1996 1349 1355
19. Hershberger R Mechanism of action of bucindolol in human ventricular myocardium J Cardiovasc Pharmacol 15 1990 959 967
20. Packer M Gheorghiade M Young JB Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors N Engl J Med 329 1993 1 7
21. on behalf of the PROVED investigator group Uretsky BF Young JB Shahidi E Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: Results of the PROVED trial J Am Coll Cardiol 22 1993 955 962
22. Garg R Gorlin R Smith T The effect of digoxin on mortality and morbidity in patients with heart failure N Engl J Med 336 1997 525 533
23. (abstr) Gheorghiade M Young JB Uretsky BF The effects of digoxin withdrawal in patients with stable heart failure due to coronary artery disease compared to primary cardiomyopathy; insights from the PROVED and RADIANCE studies Circulation 92 1995 1 142
24. Cleland JGF Bulpitt CJ Falk RH Is aspirin safe for patients with heart failure? Br Heart J 74 1995 215 219
25. Kjekshus J Pedersen TR Olsson AG The effects of simvastatin on the incidence of heart failure patients with coronary heart disease J Card Fail 3 1997 249 254
26. (suppl) Cleland JGF Dutka DP Optimising heart failure pharmacotherapy: The ideal combination Br Heart J 72 1994 S73 S79