Detection of mutations and polymorphism of N-acetyltransferase 1 gene in Indian, Malay and Chinese populations

Pharmacogenetics

Volumn 8, Issue 4, 1998, Pages 299-304

  Zhao, Bin ^a   Lee, Edmund J D ^a   Yeoh, Peng Nam ^b   Gong, Ngie Hee ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Chinese; Indians; Malays; N acetyltransferase 1; Polymorphism

Indexed keywords

ACYLTRANSFERASE;

ADULT; AGED; ALLELE; ARTICLE; CANCER RISK; CHINESE; COLORECTAL CANCER; ENZYME ACTIVITY; ETHNIC GROUP; FEMALE; GENETIC POLYMORPHISM; HUMAN; INDIAN; MALE; MUTATION; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SINGAPORE; XENOBIOTIC METABOLISM;

ACETYLTRANSFERASES; ADULT; AGED; ALLELES; ARYLAMINE N-ACETYLTRANSFERASE; ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; HUMANS; INDIA; ISOENZYMES; MALAYSIA; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC;

EID: 0031852148     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-199808000-00003     Document Type: Article

References (19)

1. Bell DA, Badawi AF, Lang NP, Ilett KF, Kadluhar FF, Hirvonen A. Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. Cancer Res 1995a; 55:5226-5229.
2. Bell DA, Stephens EA, Castranio T, Umbach DM, Watson MA, Deakin M, et al. Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer. Cancer Res 1995b; 55:3557-3542.
3. Blum M, Grant DM, McBride OW, Hein M, Meyer UA. Human arylamine N-acelyltransferase genes: isolation, chromosomal localization and functional expression. DNA Cell Biol 1990; 9:193-203.
4. Ebisawa T, Deguchi T. Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acctyltransferases. Biochem Biophys Res Commun 1991; 177:1252-1257.
5. Evans DAP, Manley KA, Mckusick VA. Genetic control of isoniazid metabolism in man. Br Med J 1960; 2: 485-461.
6. Frederickson SM, Messing EM, Resnikoff CA, Swaminathan S. Relationship between in vivo acetylator phenotypes and cytosolic N-acetyltransferase and O-acetyltransferase activities in human uroepithelial cells. Cancer Epidemiol Biomarkers Prev 1994; 3:25-32.
7. Grant DM, Blum M, Beer M, Meyer TA. Monomorphic and polymorphic human arylamine N-acelyltransferases: a comparison of liver isozymes and expressed products of two cloned genes. Mol Pharmacol 1991; 38:184-191.
8. Hein DW, Doll MA, Rustan TD, Gray K, Feng Y, Ferguson RJ, et al. Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and NAT2 acetyltransferases. Carcinogenesis 1993; 14:1633-1638.
9. Kirlin WG, Trinidad A, Yerokum T, Ogolla F, Ferguson RJ, Andrews AF, et al. Polymorphic expression of acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosols. Cancer Res 1989; 49:2448-2454.
10. Minchin R, Reeves PT, Teitel CH, McManus ME, Mojarrabi B, Ilett KF, et al. N- and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells. Biochem Biophys Res Commun 1992; 185:839-844.
11. Ohsako S, Deguchi T. Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver. J Biol Chem 1990; 265:4630-4634.
12. Probst M, Blum M, Fasshauer I, D'Orazio D, Meyer U, Wild D. The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidaxo[4,5-(Latin small letter esh)]Iquinoline(IQ). Carcinogenesis 1992; 13:1713-1717.
13. Taylor JA, Umbach D, Stephens E, Paulson D, Robertson C, Mohler JL, et al. Role of N-acetylation polymorphism at NAT1 and NAT2 in smoking-associated bladder cancer [abstract]. Proc Am Assoc Cancer Res 1995; 36:282.
14. Tureskey R, Lang N, Butler M, Teitel C, Kadlubar F. Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon. Carcinogenesis 1991; 12:1417-1422.
15. Vatsis KP, Weber WW. Structural hetergenicity of Caucasian N-acetyltransferase at the NAT1 gene locus. Arch Biochem Biophys 1993; 301:71-76.
16. Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DAP, Grant DM, et al. Nomenclature for N-acelyltranferases. Pharmacogenetics 1995; 5:1-9.
17. Weber WW, Vatsis KP. Individual variability in p-aminobenzoic acid N-acetylation by human N-acetyltransferase (NAT1) of peripheral blood. Pharmacogenetics 1993; 3:209-212.
18. Weber WW, Vatsis KP. Human N-acetyltransferases: genetic polymorphism and metabolic profiles of the major isoforms. In: Pacifici GM, Fracchia GN. editors. Advances in drug metabolism in man. Luxembourg: European Commission; 1995. pp. 351-406.
19. Zhao B, Fee EJD, Wong JVY, Yeoh PN, Gong NH. Frequency of mutant CYP1a1, NAT2 and GSTM1 alleles in normal Indians and Malays. Pharmacogenetics 1995; 5:275-280.