The effect of eliprodil on the evolution of a focal cerebral ischaemia in vivo

European Journal of Pharmacology

Volumn 352, Issue 1, 1998, Pages 29-35

  Ibarrola, Danielle ^a   Seegers, Hélène ^a   Jaillard, Assia ^a   Hommel, Marc ^a   Décorps, Michel ^a   Massarelli, Raphael ^a  

^a HÔPITAL MICHALLON   (France)

Author keywords

Cerebral ischaemia; Diffusion magnetic resonance imaging; Eliprodil; Middle cerebral artery occlusion; NMDA receptor antagonist

Indexed keywords

ELIPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; HISTOCHEMISTRY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCLUSIVE CEREBROVASCULAR DISEASE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN ISCHEMIA; EXCITATORY AMINO ACID ANTAGONISTS; MAGNETIC RESONANCE IMAGING; MALE; MULTIVARIATE ANALYSIS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0031852006     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00330-6     Document Type: Article

References (43)

1. Benveniste, H., Heclund, L., Johnson, G., 1992. Mechanism of detection of acute cerebral ischaemia in rats by diffusion-weighted magnetic resonance microscopy. Stroke 23, 746-754.
2. Boast, C., Gerhardt, S., Pastor, G., 1988. The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischaemic brain damage in gerbils. Brain Res. 442, 345-352.
3. Buchan, A., Li, H., Cho, S., Pulsinelli, W., 1991. Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischaemia in adult rats. Neuroscience 132, 255-261.
4. Carney, J., Tatsuno, T., Floyd, R., 1992. The role of oxygen radicals in ischaemic brain damage: free radical production, protein oxidation and tissue dysfunction. In: Krieglstein, J., Oberpichler-Schwenk, H. (Eds.), Pharmacology of Cerebral Ischaemia. Wissenschaftliche VerlagsGesellschaft, Stuttgart, pp. 321-331.
5. Carter, C., Benavides, J., Legendre, P., Vincent, J., Noel, F., Thuret, F., Lloyd, K., Arbilla, S., Zivkovic, B., MacKenzie, E., Scatton, B., Langer, S., 1988. Ifenprodil and SL 82.0715 as cerebral anti-ischaemic agents: II. Evidence for N-methyl-D-aspartate receptor antagonist properties. J. Pharmacol. Exp. Ther. 247, 1222-1232.
6. Carter, C., Lloyd, K., Zivkovic, B., Scatton, B., 1990. Ifenprodil and SL 82.0715 as cerebral anti-ischaemic agents: III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex. J. Pharmacol. Exp. Ther. 253, 475-482.
7. Dempsey, R., Roy, M., Meyer, K., Tai, H., Olson, J., 1985. Polyamine and prostaglandin markers in focal cerebral ischaemia. Neurosurgery 17, 635-640.
8. Dempsey, R., Roy, M., Cowen, D., Combs, D., 1988. Polyamine inhibition preserves somatosensory evoked potential activity after transient cerebral ischaemia. Neurol. Res. 10, 141-144.
9. Duval, D., Roome, N., Gauffeny, C., Nowicki, J., Scatton, B., 1992. SL 82.0715, an NMDA antagonist acting at the polyamine site, does not induce neurotoxic effects on rat cortical neurons. Neurosci. Lett. 137, 193-197.
10. Elger, B., Seega, J., Raschack, M., 1994. Oedema reduction by levemopamil in focal cerebral ischaemia of spontaneously hypertensive rats studied by magnetic resonance imaging. Eur. J. Pharmacol. 254, 65-71.
11. Finelli, D., Hopkins, A., Selman, W., Crumrine, R., Bhatti, S., Lust, W., 1992. Evaluation of experimental early acute cerebral development of oedema: use of dynamic contrast-enhanced and diffusion-weighted MR scanning. Magn. Reson. Med. 27, 189-197.
12. Gill, R., Nordholm, L., Lodge, D., 1992. The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 580, 35-41.
13. Gill, R., Sibson, N., Maskell, L., Carpenter, T., Hall, L., Pickard, J., 1996. The protective effect of MK-801 on infarct development over a period of 24 h as assessed by diffusion-weighted magnetic resonance imaging. NMR Biomed. 9, 241-253.
14. Gotti, B., Duverger, D., Bertin, J., Carter, C., Dupont, R., Frost, J., Gaudilliere, B., MacKenzie, E., Rousseau, J., Scatton, B., Wick, A., 1988. Ifenprodil and SL 82.0715 as cerebral anti-ischaemic agents: I. Evidence for efficacy in models of focal cerebral ischaemia. J. Pharmacol. Exp. Ther. 247, 1211-1221.
15. Hara, H., Sukamoto, T., Kogure, K., 1993. Mechanism and pathogenesis of ischaemia-induced neuronal damage. Prog. Neurobiol. 40, 645-670.
16. Hasegawa, Y., Fisher, M., Baron, B., Metcalf, G., 1994. The competitive NMDA antagonist MDL-100, 453 reduces infarct size after experimental stroke. Stroke 25, 1241-1246.
17. Hoehn-Berlage, M., 1995. Diffusion-weighted NMR imaging: application to experimental focal cerebral ischaemia. NMR Biomed. 8, 345-358.
18. Hossmann, K., 1996. Excitotoxic mechanisms in focal ischaemia. In: Siesjö, B., Wieloch, T., (Eds.), Advances in Neurology. Lippincott-Raven, New York, NY, pp. 69-74.
19. Hossmann, K., Fischer, M., Bockhorst, K., Hoehn-Berlage, M., 1994. NMR imaging of the apparent diffusion coefficient ADC for the evaluation of metabolic suppression and recovery after prolonged cerebral ischaemia. J. Cereb. Blood Flow Metab. 14, 723-731.
20. Hould, R., 1984. Techniques d'histopathologie et de cytopathologie. Maloine, Paris.
21. Kirino, T., 1982. Delayed neuronal death in gerbil hippocampus following ischaemia. Brain Res. 239, 57-69.
22. Koizumi, J., Yoshida, Y., Nakazawa, T., Ooneda, G., 1986. Experimental studies of ischaemic brain oedema: 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischaemic area. Jpn. J. Stroke 8, 1-8.
23. Le Bars, E., Roussel, S., Rémy, C., Loubinoux, I., Devoulon, P., Méric, P., Pinard, E., Dupeyre, R., Décorps, M., Massarelli, R., 1996. Delayed progression of cytotoxic oedema in focal cerebral ischaemia after treatment with a torasemide derivate: a diffusion-weighted magnetic resonance imaging study. Neurosci. Lett. 213, 123-126.
24. Le Peillet, E., Arvin, B., Moncada, C., Meldrum, B., 1992. The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat. Brain Res. 571, 115-120.
25. Lo, E., Matsumoto, K., Pierce, A., Garido, L., Luttinger, D., 1994. Pharmacologic reversal of acute changes in diffusion-weighted magnetic resonance imaging in focal cerebral ischaemia. J. Cereb. Blood Flow Metab. 14, 597-603.
26. 2+. In: Krieglstein, J., Oberpichler-Schwenk, H. (Eds.), Pharmacology of Cerebral Ischaemia. Wissenschaftliche VerlagsGesellschaft, Stuttgart, pp. 3-11.
27. 2-weighted MRI for the early detection of cerebral ischaemia and reperfusion in rats. Magn. Reson. Med. 18, 39-50.
28. 2-weighted MRI and spectroscopy. Magn. Reson. Med. 14, 330-346.
29. Müller, T., Haraldseth, O., Jones, R., Sebastiani, G., Lindboe, C., Unsgard, G., Oksendal, A., 1995. Perfusion and diffusion-weighted MR imaging for in vivo evaluation of treatment with U74389G in a rat stroke model. Stroke 26, 1453-1458.
30. Nishikawa, T., Kirsch, J., Koehler, R., Miyabe, M., Traytsman, R., 1994. Competitive N-methyl-D-aspartate receptor blockade reduces brain injury following transient focal ischaemia in cats. Stroke 25, 2258-2264.
31. Paschen, W., 1992. Polyamine metabolism in reversible cerebral ischaemia. Cerebrovasc. Brain Metab. Rev. 4, 59-88.
32. Paxinos, G., Watson, C., 1982. The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego, CA.
33. Perez-Trepichio, A., Xue, M., Thian, C., Majors, A., Furlan, A., Awad, I., Jones, S., 1995. Sensitivity of magnetic resonance diffusion-weighted imaging and regional relationship between the apparent diffusion coefficient and cerebral blood flow in rat focal cerebral ischaemia. Stroke 26, 667-675.
34. Roussel, S., Pinard, E., Seylaz, J., 1992. The acute effects of MK-801 on cerebral blood flow and tissue partial pressures of oxygen and carbon dioxide in conscious and alpha-chloralose anaesthetised rats. Neuroscience 47, 959-965.
35. Roussel, S., Van Bruggen, N., King, M., Houseman, J., Williams, S., Gadian, D., 1994. Monitoring the initial expansion of focal ischaemic changes by diffusion weighted magnetic resonance imaging using a remote controlled method of occlusion. NMR Biomed. 7, 21-28.
36. Sauer, D., Allegrini, P., Cosenti, A., Pataki, A., Amacker, H., Fagg, G., 1993. Characterization of the cerebroprotective efficacy of the com-petitive NMDA receptor antagonist CGP40116 in a rat model of focal cerebral ischaemia: an in vivo magnetic resonance imaging study. J. Cereb. Blood Flow Metab. 13, 596-602.
37. Sevick, R., Kanda, F., Mintorovitch, J., Arieff, A., Kucharczyk, J., Tsuruda, J., Norman, D., Moseley, M., 1992. Cytotoxic brain oedema: assessment with diffusion-weighted MR imaging. Radiology 185, 687-690.
38. Siesjö, B., 1992a. Pathophysiology and treatment of focal cerebral ischaemia: Part I. Pathophysiology. J. Neurosurg. 77, 169-184.
39. Siesjö, B., 1992b. Pathophysiology and treatment of focal cerebral ischaemia: Part II. Mechanisms of damage and treatment. J. Neurosurg. 77, 337-354.
40. Simon, R., Shiraishi, K., 1990. N-methyl-D-aspartate antagonist reduces stroke size and glucose metabolism. Ann. Neurol. 27, 606-612.
41. Smith, S., Meldrum, B., 1992. Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischaemia. Stroke 23, 861-864.
42. Torregrosa, G., Salom, J., Jover, T., Alabadi, J., Miranda, F., Alborch, E., 1994. Evidence of a direct constrictor action of MK-801 and its modulation by the endothelium in cerebral arteries. J. Vasc. Res. 31, 211-229.
43. Xue, D., Huang, Z., Barnes, K., Lesiuk, H., Smith, K., Buchan, A., 1994. Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction. J. Cereb. Blood Flow Metab. 14, 251-261.