Effect of colchicine on chronic ciclosporin nephrotoxicity in Sprague-Dawley rats

Nephron

Volumn 79, Issue 4, 1998, Pages 452-457

  Sobh, Mohamed ^a   Sabry, Alaa ^a   Moustafa, Fatma ^a   Foda, Mohamed A ^a   Sally, Samir ^a   Ghoneim, Mohamed ^a  

^a MANSOURA UNIVERSITY   (Egypt)

Author keywords

Ciclosporin nephrotoxicity; Colchicine; Fibrosis

Indexed keywords

ALKALOID; COLCHICINE; CREATININE; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; POTASSIUM ION; SODIUM ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; CREATININE URINE LEVEL; DRUG BLOOD LEVEL; FIBROSING ALVEOLITIS; HISTOPATHOLOGY; KIDNEY TUBULE; MALE; NEPHROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; POTASSIUM BLOOD LEVEL; POTASSIUM URINE LEVEL; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RAT; SODIUM BLOOD LEVEL; SODIUM URINE LEVEL;

ANIMALS; BODY WEIGHT; COLCHICINE; CYCLOSPORINE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY CORTEX; KIDNEY DISEASES; KIDNEY MEDULLA; MALE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 0031849497     PISSN: 00282766     EISSN: None     Source Type: Journal    
DOI: 10.1159/000045092     Document Type: Article

References (8)

1. Merion RM, White DJG, Thiru S, Evans DB: Cyclosporine: Five years experience in cadaveric renal transplantation. N Engl J Med 1994;310:148-154.
2. Myers BD, Newton L, Boskhoser C: Chronic injury of human renal microvessels with low dose cyclosporin therapy. Transplantation 1988;146:2007-2010.
3. Thiru S, Maher ER, Hamilton DV, Evans DB, Calne RY: Tubular changes in renal transplant recipients on cyclosporin. Transplant Proc 1983;15:2846-2851.
4. Bergstrand A, Bohmann SO, Fransworth A: Renal histopathology in kidney transplant recipients immunosuppressed with ciclosporin A, Clin Nephrol 1985;24:107-119.
5. Sobh M, Moustafa F, Hamed S, Ghoneim M: Study of the effect of colchicine on Schistosoma-induced renal amyloidosis in Syrian golden hamsters. Nephron 1995;70:478-485.
6. Matsumoto T, Mizunoe Y: Suitability of colchicine and Superoxide dismutase for the suppression of renal scarring following an infection with bacteria showing mannose-sensitive pili. Nephron 1990;56:130-135.
7. Kershenobich D, Vargas F, Gracia-Tsao G: Colchicine in the treatment of cirrhosis of the liver. N Engl J Med 1989;318:1709-1713.
8. McClurkin C Jr, Phan SH, Hsu CH: Moderate protection of renal function and reduction of fibrosis by colchicine in a model of anti-GBM disease in the rabbit. J Am Soc Nephrol 1990; 1: 257-265.