Partial agonistic activity of naloxone on the opioid receptors expressed from complementary deoxyribonucleic acids in Chinese hamster ovary cells

Anesthesia and Analgesia

Volumn 87, Issue 2, 1998, Pages 450-455

  Fukuda, Kazuhiko ^a   Kato, Shigehisa ^a   Shoda, Takehiro ^a   Morikawa, Hitoshi ^a   Mima, Hiroyuki ^a   Mori, Kenjiro ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; COMPLEMENTARY DNA; CYCLIC AMP; DELTA OPIATE RECEPTOR; DIPRENORPHINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; NALOXONE; OPIATE RECEPTOR; PARTIAL AGONIST; PERTUSSIS TOXIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DNA TRANSFECTION; DRUG ACTIVITY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CYCLIC AMP; DIPRENORPHINE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; FORSKOLIN; GTP PHOSPHOHYDROLASES; NALOXONE; RECEPTORS, CELL SURFACE; RECEPTORS, OPIOID; TRANSFECTION;

EID: 0031849421     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199808000-00041     Document Type: Article

References (25)

1. Pleuvry BJ. Opioid receptors and their relevance to anaesthesia. Br J Anaesth 1993;71:119-26.
2. Loh HH, Smith AP. Molecular characterization of opioid receptors. Annu Rev Pharmacol Toxicol 1990;30:123-47.
3. Minami M, Satoh M. Molecular biology of the opioid receptors: structures, functions and distributions. Neurosci Res 1995;23: 121-45.
4. Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ. Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem 1991;60:653-88.
5. Fukuda K, Kato S, Mori K. Location of regions of the opioid receptor involved in selective agonist binding. J Biol Chem 1995;270:6702-9.
6. Fukuda K, Terasako K, Kato S, Mori K. Identification of the amino acid residues involved in selective agonist binding in the first extracellular loop of the δ-and μ-opioid receptors. FEBS Lett 1995;373:177-81.
7. Reisine T, Pasternak G. Opioid analgesics and antagonists. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. Goodman and Gilman's the pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill, 1996:521-55.
8. Martin WR. Pharmacology of opioids. Pharmacol Rev 1984;35: 283-323.
9. Levine JD, Gordon NC, Fields HL. Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain. Nature 1979;278:740-1.
10. Woolf CJ. Analgesia and hyperalgesia produced in the rat by intrathecal naloxone. Brain Res 1980;189:593-7.
11. Fukuda K, Kato S, Morikawa H, et al. Functional coupling of the δ-, μ-, and κ-opioid receptors to mitogen-activated protein kinase and arachidonate release in Chinese hamster ovary cells. J Neurochem 1996;67:1309-16.
12. Sambrook J, Fritsch EF, Maniatis T. Expression of cloned genes in cultured mammalian cells. In: Sambrook J, Fritsch EF, Maniatis T, eds. Molecular cloning. 2nd ed. New York: Cold Spring Harbor Laboratory Press, 1989:16.1-81.
13. Fukuda K, Kato S, Mori K, et al. Primary structures and expression from cDNAs of rat opioid receptor δ-and μ-subtypes. FEBS Lett 1993;327:311-4.
14. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
15. Leslie FM. Methods used for the study of opioid receptors. Pharmacol Rev 1987;39:197-249.
16. Goldstein A, Naidu A. Multiple opioid receptors: ligand selectivity profiles and binding site signatures. Mol Pharmacol 1989; 36:265-72.
17. Evans CJ, Keith DE Jr, Morrison H, et al. Cloning of a delta opioid receptor by functional expression. Science 1992;258: 1952-5.
18. Johnson PS, Wang JB, Wang WF, Uhl GR. Expressed mu opiate receptor couples to adenylate cyclase and phosphatidyl inositol turnover. Neuroreport 1994;5:507-9.
19. Bunzow JR, Zhang G, Bouvier C, et al. Characterization and distribution of a cloned rat μ-opioid receptor. J Neurochem 1995;64:14-24.
20. Smart D, Lambert DG. The stimulatory effects of opioids and their possible role in the development of tolerance. Trends Pharmacol Sci 1996;17:264-9.
21. Mullaney I, Carr IC, Milligan G. Analysis of inverse agonism at the δ opioid receptor after expression in rat 1 fibroblasts. Biochem J 1996;315:227-34.
22. Wang Z, Bilsky EJ, Porreca F, Sadée W. Constitutive μ opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence. Life Sci 1994;54:PL339-50.
23. Shen K-F, Crain SM. Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice. Brain Res 1997;757:176-90.
24. Spivak CE, Beglan CL, Seidleck BK, et al. Naloxone activation of μ-opioid receptors mutated at a histidine residue lining the opioid binding cavity. Mol Pharmacol 1997;52:983-92.
25. Bot G, Blake AD, Li S, Reisine T. Mutagenesis of the mouse delta opioid receptor converts (-)-buprenorphine from a partial agonist to an antagonist. J Pharmacol Exp Ther 1998;284:283-90.