The diverse molecular basis and mild clinical picture of HbH disease in Israel

Annals of the New York Academy of Sciences

Volumn 850, Issue , 1998, Pages 432-435

  Tamary, H ^a,b   Klinger, G ^a   Shalmon, L ^b   Kirschmann, H ^b   Koren, A ^c   Bennet, M ^c   Zaizov, R ^a,b  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c Afula Medical Center   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN H;

ALPHA THALASSEMIA; CLINICAL ARTICLE; CONFERENCE PAPER; GENE DELETION; GENE FREQUENCY; GENOTYPE; GLOBIN GENE; HEMOGLOBIN H DISEASE; HUMAN; HUMAN CELL; PHENOTYPE; POINT MUTATION;

EID: 0031849044     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb10513.x     Document Type: Conference Paper

References (11)

1. HALBRECHT, I. & S. BEN PORAT. 1967. The incidence of Bart's hemoglobin in the cord blood of 3,218 newborns of different ethnic groups in Israel. Harefuah 73: 233-235.
2. ZAIZOV, R. & Y. MATOTH. 1972. α-thalassemia in Yemenite and Iraqi Jews. Isr. J. Med. Sci. 8: 11-17.
3. HONIG, G. et al. 1981. Hemoglobin Petah Tikva (α110 Ala→Asp): A new unstable variant with α-thalassemia like expression. Blood 57: 705-711.
4. GALACTEROS, F. et al. 1994. Hb Taybe (α38 or α39 deleted): An α-globin defect, silent in the heterozygous state and producing severe hemolytic anemia in the homozygous. C. R. Acad. Sci. 317: 437-444.
5. SHALMON, L. et al. 1994. A new deletional alpha thalassemia detected in Yemenites with hemoglobin H disease. Am. J. Hematol. 45: 201-204.
6. TAMARY, H. et al 1997. Alpha-thalassemia induced by a novel 16bp deletion in the 3' untranslated region of the α2 including the first base of the poly A signal. Hemoglobin 21: 121-130.
7. GALANELLO, R. et al. 1992. HbH disease in Sardinia: Molecular, hematological and clinical aspects. Acta Haematol. 88: 1-6.
8. BAYSL, E. et al. 1995. Alpha-thalassemia in the population of Cyprus. Br. J. Haematol. 89: 469-499.
9. NOVELLETTO, A. et al. 1989. Frequency and molecular types of deletional α-thalassemia in Egypt. Hum. Gen. 81: 211-213.
10. TRAEGER-SYNODINOS, J. E. et al. Characterization of nondeletion α-thalassemia mutations in the Greek population. Am. J. Hematol. 44: 162-167.
11. HUI, C. H. et al. 1990. Iron overload in Chinese patients with hemoglobin H disease. Am. J. Hematol. 34: 287-290.