Caffeine-derived N-nitroso compounds. V. carcinogenicity of mononitrosocaffeidine and dinitrosocaffeidine in bd-ix rats

Carcinogenesis

Volumn 19, Issue 5, 1998, Pages 933-937

  Ivankovic, Stan ^a   Seibel, Jens ^a   Komitowski, Dymitr ^a   Spiegelhalder, Bertold ^a   Preussmann, Rudolf ^a   Siddiqi, Maqsood ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE DERIVATIVE; CARCINOGEN; NITROSO DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; GASTROINTESTINAL HEMORRHAGE; LUNG EDEMA; NEUROEPITHELIOMA; NONHUMAN; NOSE CAVITY TUMOR; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; RAT; SQUAMOUS CELL CARCINOMA; STOMACH CARCINOMA;

ADMINISTRATION, ORAL; ANIMALS; CAFFEINE; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LETHAL DOSE 50; MALE; MICE; NEOPLASMS, EXPERIMENTAL; NITROSAMINES; RATS;

EID: 0031848632     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.5.933     Document Type: Article

References (18)

1. Siddiqi,M. and Preussmann,R. (1989) Esophageal cancer in Kashmir: an assessment. J. Cancer Res. Clin. Oncol., 115, 111-117.
2. Khuroo,M.S., Zargar,S.A., Mahajan,R. and Banday,M.A. (1992) High incidence of oesophageal and gastric cancer in Kashmir in a population with special personal and dietary habits. Gut, 33, 11-15.
3. Siddiqi,M., Tricker,A.R. and Preussmann,R. (1988) The occurrence of preformed N-nitroso compounds in food samples from a high risk area of esophageal cancer in Kashmir, India. Cancer Lett., 39, 37-43.
4. Kumar,R., Mende,P., Tricker,A.R., Siddiqi,M. and Preussmann,R. (1990) N-nitroso compounds and their precursors in Brassica oleacea. Cancer Lett., 54, 61-65.
5. Siddiqi,M., Kumar,R., Fazili,Z., Spiegelhalder,B. and Preussmann,R. (1992) Increased exposure to dietary amines and nitrate in a population at high risk of oesophageal and gastric cancer in Kashmir, India. Carcinogenesis, 13, 1331-1335.
6. Tricker,A.R., Kumar,R., Siddiqi,M., Khuroo,M.S. and Preussmann,R. (1991) Endogenous formation of N-nitrosamines from piperazine and their urinary excretion following antihelmintic treatment with piperazine citrate. Carcinogenesis, 12, 1595-1599.
7. Kumar,R., Siddiqi,M., Fazili,Z., Wacker,C.D., Spiegelhalder,B. and Preussmann,R. (1992) Effects of dietary nitrate on endogenous nitrosation of piperazine in humans. Cancer Lett., 65, 139-143.
8. Kumar,R., Mende,P., Wacker,C.D., Spiegelhalder,B., Preussmann,R. and Siddiqi,M. (1992) Caffeine-derived N-nitroso compounds. I: Nitrosatable precursors from caffeine and their potential relevance in the etiology of esophageal and gastric cancers in Kashmir, India. Carcinogenesis, 13, 2179-2182
9. Kumar,R., Wacker,C.D., Mende,P., Spiegelhalder,B., Preussmann,R. and Siddiqi,M. (1993) Caffeine-derived N-nitroso compounds. II. Synthesis and characterization of nitrosation products from caffeidine and caffeidinic acid. Chem. Res. Toxicol., 6, 50-58.
10. Erdinger,L, Schmezer,P, Razdan,R., Kumar,R., Spiegelhalder,B., Preussmann,R. and Siddiqi,M. (1993) Caffeine-derived N-nitroso compounds. III. Mutagenicity in S. typhimurium and in vitro induction of DNA single-strand breaks in rat hepatocytes by mononitrosocaffeidine and dinitrosocaffeidine. Mutat. Res., 292, 41-49.
11. Razdan,R., Frei,E., Spiegelhalder,B. and Siddiqi,M. (1994) Caffeine-derived N-nitroso compounds. IV. Kinetics of mononitrosocaffeidine demethylation by rat liver microsomes. Cancer Lett., 79, 117-122.
12. White,E.H. (1955) The chemistry of N-alkyl-N-nitrosamides. 1. Methods of preparation. J. Am. Chem. Soc., 77, 6008-6010.
13. Burn,J.H. (1937) Biologische Auswertungsmethoden. Springer-Verlag, Berlin.
14. Bartsch,H. and Montesano,R. (1984) Relevance of nitrosamines to human cancer. Carcinogenesis, 5, 1381-1393.
15. Hecht,S.S. and Hoffmann,D. (1991) N-nitroso compounds and tobacco-induced cancers in man. In O'Neil,I.K., Chen,J.S. and Bartsch,H. (eds) Relevance to Human Cancer of Nitroso Compounds, Tobacco and Mycotoxins, IARC Scientific Publication No. 105. IARC, Lyon, pp. 54-61.
16. Mirvish,S.S. (1983) The etiology of gastric cancer: intragastric formation and other theories. J. Natl. Cancer Inst., 71, 631-647.
17. Preussmann,R. (1987) Chemical factors in the pathogenesis of esophageal carcinoma. In Wagner,G and Hi,Z.Y (eds) Cancer of Liver, Esophagus and Nasopharynx. Springer-Verlag, Heidelberg, pp. 119-123.
18. Preussmann,R. and Stewart,B.W. (1984) N-nitroso carcinogens. In Searle,C.E. (ed.) Chemical Carcinogens, ACS Monograph No. 182, 2nd edn. American Chemical Society, Washington, DC, pp. 643-828.