Complement activates phospholipases and protein kinases in glomerular epithelial cells

Kidney International

Volumn 54, Issue 2, 1998, Pages 360-372

  Cybulsky, Andrey V ^a   Papillon, Joan ^a   McTavish, Alison J ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Arachidonic acid; Diacylglycerol PKC pathway; Eicosanoids; Injury; Membranous nephropathy; Phospholipase A2; Proteinuria

Indexed keywords

ALANINE; ARACHIDONIC ACID; CALCIUM; COMPLEMENT MEMBRANE ATTACK COMPLEX; DIACYLGLYCEROL; EPIDERMAL GROWTH FACTOR; ICOSANOID; INOSITOL PHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE A2; PROTEIN KINASE; PROTEIN KINASE C; SERINE; THROMBIN; TRITIUM; TYROSINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GLOMERULUS EPITHELIUM; MEMBRANOUS GLOMERULONEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

EID: 0031848459     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00013.x     Document Type: Article

References (56)

1. 2 and signal transduction. J Am Soc Nephrol 3:128-150, 1992
2. 2. J Biol Chem 269:13057-13060, 1994
3. 2 superfamily of signal transduction enzymes. Trends Biochem Sci 22:1-2, 1997
4. 2 gene family in mammals. J Biol Chem 272:17247-1720, 1997
5. 2. J Biol Chem 272:16709-16712, 1997
6. 2 in glomerular epithelial cells. Am J Physiol 269:F739-F749, 1995
7. 2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells. J Biol Chem 271:21505-21513, 1996
8. 2+-independent catalytic domain. J Biol Chem 269:18239-18249, 1994
9. 2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen. J Biol Chem 270:15359-15367, 1995
10. 2 to the nuclear envelope and endoplasmic reticulum. J Biol Chem 270:30749-30754, 1995
11. 2 is phosphorylated and activated by MAP kinase. Cell 72:269-278, 1993
12. MALARKEY K, BELHAM CM, PAUL A, GRAHAM A, MCLEES A, SCOTT PH, PLEVIN R: The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors. Biochem J 309: 361-375, 1995
13. SEGER R, KREBS EG: The MAPK signaling cascade. FASEB J 9:726-735, 1995
14. KYRIAKIS JM, AVRUCH J: Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays 18:567-577, 1996
15. NISHIZUKA Y: Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9:484-496, 1995
16. HUG H, SARRE TF: Protein kinase C isoenzymes: Divergence in signal transduction? Biochem J 291:329-343, 1993
17. COCKCROFT S, THOMAS GMH: Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors. Biochem J 288:1-14, 1992
18. 2 hydrolysis and regulation of phospholipase C isozymes. Curr Opin Cell Biol 7:183-189, 1995
19. MORGAN BP: Effects of the membrane attack complex of complement on nucleated cells. Curr Topics Microbiol Immunol 178:115-140, 1992
20. NICHOLSON-WELLER A, HALPERIN JA: Membrane signaling by complement C5b-9, the membrane attack complex. Immunol Res 12:244-257, 1993
21. CYBULSKY AV, SALANT DJ, QUIGG RJ, BADALAMENTI J, BONVENTRE JV: Complement C5b-9 complex activates phospholipases in glomerular epithelial cells. Am J Physiol 257:F826-F836, 1989
22. CYBULSKY AV, BONVENTRE JV, QUIGG RJ, LIEBERTHAL W, SALANT DJ: Cytosolic calcium and protein kinase C reduce complement-mediated glomerular epithelial injury. Kidney Int 38:803-811, 1990
23. NICULESCU F, RUS H, SHIN ML: Receptor-independent activation of guanine nucleotide-binding regulatory proteins by terminal complement complexes. J Biol Chem 269:4417-4423, 1994
24. NICULESCU F, RUS H, VAN BIESEN T, SHIN ML: Activation of Ras and mitogen-activated protein kinase pathway by terminal complement complexes is G protein dependent. J Immunol 158:4405-4412, 1997
25. HALPERIN JA, TARATUSKA A, NICHOLSON-WELLER A: Terminal complement complex C5b-9 stimulates mitogenesis in 3T3 cells. J Clin Invest 91:1974-1978, 1993
26. CYBULSKY AV, RENNKE HG, FEINTZEIG ID, SALANT DJ: Complement-induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy. J Clin Invest 77: 1096-1107, 1986
27. KERJASCHKI D, SCHULZE M, BINDER S, KAIN R, OJHA PP, SUSANI M, HORVAT R, BAKER PJ, COUSER WG: Transcellular transport and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy. J Immunol 143:546-552, 1989
28. STAHL RAK, ADLER S, BAKER PJ, CHEN YP, PRITZL PM, COUSER WG: Enhanced glomerular prostaglandin formation in experimental membranous nephropathy. Kidney Int 31:1126-1131, 1987
29. WEISE WJ, NATORI Y, LEVINE JS, O'MEARA YM, MINTO AW, MANNING EC, GOLDSTEIN DJ, ABRAHAMSON DR, SALANT DJ: Fish oil has protective and therapeutic effects on proteinuria in passive Heymann nephritis. Kidney Int 43:359-368, 1993
30. 2 synthase inhibitor, on passive Heymann nephritis in rats. Eur J Pharmacol 316:73-80, 1996
31. CYBULSKY AV, LIEBERTHAL W, QUIGG RJ, RENNKE HG, SALANT DJ: A role for thromboxane in complement-mediated glomerular injury. Am J Pathol 128:45-51, 1987
32. ZOJA C, BENIGNI A, VERROUST P, RONCO P, BERTANI T, REMUZZI G: Indomethacin reduces proteinuria in passive Heymann nephritis in rats. Kidney Int 31:1335-1343, 1987
33. YOSHIOKA T, RENNKE HG, SALANT DJ, DEEN WM, ICHIKAWA I: Role of abnormally high transmural pressure in the permselectivity defect of glomerular capillary wall: A study in early passive Heymann nephritis. Circ Res 61:531-538, 1987
34. QUIGG RJ, CYBULSKY AV, JACOBS JB, SALANT DJ: Anti-Fx1A produces complement-dependent cytotoxicity of glomerular epithelial cells. Kidney Int 34:43-52, 1988
35. 2 by complement C5b-9 in glomerular epithelial cells. J Immunol 159:3584-3594, 1997
36. CYBULSKY AV: Release of arachidonic acid by complement C5b-9 complex in glomerular epithelial cells. Am J Physiol 261:F427-F436, 1991
37. CYBULSKY AV, CYR MD: Phosphatidylcholine-directed phospholipase C: Activation by complement C5b-9. Am J Physiol 265:F551-F560, 1993
38. CYBULSKY AV, MCTAVISH AJ, PAPILLON J: Extracellular matrix stimulates production and breakdown of inositol phospholipids. Am J Physiol 271:F579-F587, 1996
39. 2 expressed in insect cells is extensively phosphorylated on ser-505. Biochim Biophys Acta 1244:157-164, 1995
40. HEASLEY LE, JOHNSON GL: Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells. J Biol Chem 264:8646-8652, 1989
41. YASUDA I, KISHIMOTO A, TANAKA S, TOMINAGA M, SAKURAI A, NISHIZUKA Y: A synthetic peptide substrate for selective assay of protein kinase C. Biochem Biophys Res Comm 166:1220-1227, 1990
42. CYBULSKY AV, MCTAVISH AJ: Extracellular matrix is required for MAP kinase activation and proliferation of rat glomerular epithelial cells. Biochem Biophys Res Comm 231:160-166, 1997
43. DUDLEY DT, PANG L, DECKER SJ, BRIDGES AJ, SALTIEL AR: A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 92:7686-7689, 1995
44. MARAIS R, LIGHT Y, PATTERSON HF, MASON CS, MARSHALL CJ: Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic Ras and tyrosine kniases. J Biol Chem 272:4378-4383, 1997
45. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C. J Biol Chem 268:1960-1964, 1993
46. 2 expressed in insect cells and present in monocytes. J Biol Chem 271:6987-6997, 1996
47. 2 in macrophages. Biochem J 325:405-410, 1997
48. HUWILER A, SCHULZE-LOHOFF E, FABBRO D, PFEILSCHIFTER J: Immunocharacterization of protein kinase C isoenzymes in rat kidney glomeruli, and cultured glomerular epithelial and mesangial cells. Exp Nephrol 1:19-25, 1993
49. LIAO F, SHIN HS, RHEE SG: In vitro tyrosine phosphorylation of PLC-γ1 and PLC-γ2 by scr-family protein tyrosine kinases. Biochem Biophys Res Comm 191:1028-1033, 1993
50. MARRERO MB, SCHIEFFER B, PAXTON WG, SCHIEFFER E, BERNSTEIN KE: Electroporation of pp60c-src antibodies inhibits the angiotensin II activation of phospholipase C-γ1 in rat aortic smooth muscle cells. J Biol Chem 270:15734-15738, 1995
51. 2+-initiated activation of cellular protein kinases. J Biol Chem 262:13674-13681, 1987
52. CARNEY DF, LANG TJ, SHIN ML: Multiple signal messengers generated by terminal complement complexes and their role in terminal complement complex elimination. J Immunol 145:623-629, 1990
53. NICULESCU F, RUS H, SHIN S, LANG T, SHIN ML: Generation of diacylglycerol and ceramide during homologous complement activation. Immunol 150:214-224, 1993
54. FLOEGE J, JOHNSON RJ, ALPERS CE, FATEMI-NAINIE S, RICHARDSON CA, GORDON K, COUSER WG: Visceral glomerular epithelial cells can proliferate in vivo and synthesize platelet-derived growth factor B-chain. Am J Pathol 142:637-650, 1993
55. 558 are produced by kidney glomerular cells in passive Heymann nephritis. Proc Natl Acad Sci USA 90:3645-364, 1993
56. MCMILLAN JI, RIORDAN JW, COUSER WG, POLLOCK AS, LOVETT DH: Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy. J Clin Invest 97:1094-1101, 1996