Hyperthermic isolated limb perfusion with tumour necrosis factor and melphalan as treatment of locally advanced or recurrent soft tissue sarcomas of the extremities

Radiotherapy and Oncology

Volumn 48, Issue 1, 1998, Pages 1-4

  Koops, Heimen Schraffordt ^a   Eggermont, Alexander M M ^b   Liènard, Danielle ^c   Kroon, Bin B R ^d   Hoekstra, Harald J ^a   Van Geel, Albertus N ^b   Nieweg, Omgo E ^d   Lejeune, Ferdinand J ^c  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Regional perfusion; Sarcoma; TNF

Indexed keywords

INTERFERON; MELPHALAN; TUMOR NECROSIS FACTOR ALPHA;

ADVANCED CANCER; DRUG EFFICACY; EDEMA; HUMAN; HYPERTHERMIC THERAPY; LIMB DISEASE; LIMB SALVAGE; NEUROPATHY; PRIORITY JOURNAL; RECURRENT CANCER; REGIONAL PERFUSION; REVIEW; SOFT TISSUE SARCOMA;

EID: 0031847512     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(98)00040-1     Document Type: Article

References (19)

1. Asher, A.L., Mule, J.J., Reichert, C.M., et al. Studies of the antitumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo. J. Immunol. 138: 963-974, 1987.
2. Bramwell, V., Rouesse, J., Steward, W., et al. Adjuvant CYVADIC chemotherapy for adult soft tissue sarcoma. Reduced local recurrence but no improvement in survival: a study of the EORTC. J. Clin. Oncol. 12: 1137-1149, 1994.
3. Creech, O.J., Krementz, E.T., Ryan, R.F. and Winblad, J.N. Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit. Ann. Surg. 148: 616-632, 1958.
4. Eggermont, A.M.M., Liènard, D., Schraffordt Koops, H., et al. Treatment of irresectable soft tissue sarcomas of the limbs by isolated perfusion with high-dose TNF-α in combination with interferon-γ and melphalan. In: Tumour Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance, pp. 239-243. Editors: W. Fiers and W. Buurman. Karger, Basel, 1993.
5. Eggermont, A.M.M., Schraffordt Koops, H., Klausner, J.M., et al. Isolated limb perfusion with tumour necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas: the cumulative Multicentre European Experience. Ann. Surg. 224: 756-765, 1996.
6. Eilber, F.R., Giuliano, A.E., Huth, J.F. and Morton, D.L. A randomized prospective trial using postoperative adjuvant chemotherapy (adriamycin) in high-grade extremity soft tissue sarcoma. Am. J. Clin. Oncol. 11: 39-45, 1988.
7. Fraker, D.L., Alexander, H.R. and Pass, H.J. Biologic therapy with TNF: systemic administration and isolation-perfusion. In: Biologic Therapy of Cancer, pp. 329-345. Editors: V. DeVita, S. Hellman and S.H. Rosenberg. J.B. Lippincott, Philadelphia, PA, 1995.
8. Fraker, D.L., Alexander, H.R., Andrich, M. and Rosenberg, S.A. Treatment of patients with melanoma of the extremity using hyperthermic isolated limb perfusion with melphalan, tumour necrosis factor, and interferon gamma: results of a tumour necrosis factor dose escalation study. J. Clin. Oncol. 14: 479-489, 1996.
9. van Ginkel, R.J., Hoekstra, H.J., Eggermont, A.M.M., et al. Isolated limb perfusion of an irradiated foot with tumour necrosis factor, Interferon and melphalan. Arch. Surg. 131: 672-674, 1996.
10. Hill, S., Fawcett, W.J., Sheldon, J., et al. Low-dose tumour necrosis factor alpha and melphalan in hyperthermic isolated perfusion. Br. J. Surg. 80: 995-997, 1993.
11. Hoekstra, H.J., Mehta, D.M., Wijffels, R.T.M., Vermeij, J. and Oldhoff, J. Local tumor control by intraoperative radiotherapy (IORT). A pilot experience. Eur. J. Surg. Oncol. 17: 364-369, 1991.
12. Hoekstra, H.J., Naujocks, T., Beekhuis, H., et al. Continuous leakage monitoring during hyperthermic regional isolated perfusion of the lower limb, techniques and results. Reg. Cancer Treat. 4: 301-304, 1992.
13. Hoekstra, H.J., Schraffordt Koops, H. and Oldhoff, J. Soft tissue sarcoma of the extremity. Eur. J. Surg. Oncol. 20: 3-6, 1994.
14. Liènard, D., Ewalenko, P., Delmotte, J.J., et al. High-dose recombinant tumour necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. J. Clin. Oncol. 10: 52-60, 1992.
15. Olieman, A.F.T., van Ginkel, R.J., Hoekstra, H.J., et al. Angiographic response of locally advanced soft-tissue sarcoma following hyperthermic isolated limb perfusion with tumor necrosis factor. Ann. Surg. Oncol. 4: 64-69, 1997.
16. Renard, N., Nooijen, P.T.G.A., Schalkwijk, L., et al. VWF release and platelet aggregation in human melanoma after perfusion with TNF-α. J. Pathol. 176: 279-287, 1995.
17. Schraffordt Koops, H., Oldhoff, J., Oosterhuis, J.W. and Beekhuis, H.J. Isolated regional perfusion in malignant melanoma of the extremities. World J. Surg. 11: 527-533, 1987.
18. Schraffordt Koops, H., Eggermont, A.M.M., Liènard, D., et al. Hyperthermic isolated limb perfusion for the treatment of soft tissue sarcomas. Semin. Surg. Oncol., 14: 210-214, 1998.
19. Sugarman, B.J., Aggarwal, B.B., Hass, P.E., et al. Recombinant tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. Science 230: 943-945, 1985.