Normalization of EGFR mRNA levels following restoration of wild-type p53 in a head and neck squamous cell carcinoma cell line

International Journal of Oncology

Volumn 13, Issue 2, 1998, Pages 375-378

  Grandis, Jennifer Rubin ^a,c   Zeng, Qing ^a   Drenning, Stephanie D ^a   Tweardy, David J ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c University of Pittsburgh School of Medicine   (United States)

Author keywords

EGFR; Head and neck cancer; p53

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; PROTEIN P53;

ARTICLE; CANCER CELL CULTURE; CELL CLONE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TEMPERATURE SENSITIVE MUTANT; TUMOR SUPPRESSOR GENE;

BLOTTING, NORTHERN; CARCINOMA, SQUAMOUS CELL; DOWN-REGULATION; GENES, P53; HEAD AND NECK NEOPLASMS; HUMANS; MUTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 0031847287     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.13.2.375     Document Type: Article

References (27)

1. Di Marco E, Pierce JH, Fleming TP, Kraus MH, Molloy CJ, Aaronson SA and DiFiore PP: Autocrine interaction between TGF-α and EGF-receptor: quantitative requirements for induction of the malignant phenotype. Oncogene 4: 831-838, 1989.
2. Toi M, Osaki A, Yamada H and Toge T: Epidermal growth factor receptor expression as a prognostic indicator in breast cancer. Eur J Cancer 27: 977-980, 1991.
3. Radinsky R, Risin S, Fan D, Dong Z, Bielenberg D, Bucana CD and Fidler IJ: Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells. Clin Cancer Res 1: 19-31, 1995.
4. Harris AL and Nicholson S: Epidermal growth factor receptors in human breast cancer. Cancer Treat Res 7: 353-357, 1989.
5. Veale D, Ashcroft T, Marsh C, Gibson GJ and Harris AL: Epidermal growth factor receptors in non-small cell lung cancer. Br J Cancer 55: 513-516, 1987.
6. Atlas I, Mendelsohn J, Baselga J, Fair WR, Masui H and Kumar R: Growth regulation of human renal carcinoma cells: role of transforming growth factor-α. Cancer Res 2: 3353-3339, 1992.
7. Morishigi K, Kurachi H, Amemiya K, Fukita Y, Yamamoto T, Miyake A and Tanizawa O: Evidence for the involvement of transforming growth factor α and epidermal growth factor receptor autocrine growth mechanisms in primary human ovarian cancers in vitro. Cancer Res 51: 5322-5328, 1991.
8. Rubin Grandis J and Tweardy DT: Elevated levels of transforming growth factor α and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res 53: 3579-3584, 1993.
9. Dassonville O, Formento JL, Francoual M, Ramaioli A, Santini J, Schneider M, Demard F and Milano G: Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer. J Clin Oncol 11: 1873-1878, 1993.
10. Shin DM, Ro JY, Hong WK and Hittelman WN: Dysregulation of epidermal growth factor receptor expression in premalignant lesions during head and neck tumorigenesis. Cancer Res 54: 3153-3159, 1994.
11. Issing WJ, Liebich C, Wustrow TP and Ullrich A: Coexpression of epidermal growth factor receptor and TGF-α and survival in upper aerodigestive tract cancer. Anticancer Res 16: 283-288, 1996.
12. Rubin Grandis J, Melhem MF, Barnes EL and Tweardy DJ: Quantitative immunohistochemical analysis of transforming growth factor alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck: cellular localization and correlation with mRNA levels. Cancer 78: 1284-1292, 1996.
13. Yamamoto T, Kamata N, Kawano H, Shimizu S, Kuroki T, Toyoshima K, Rikimaru K, Nomura N, Ishizaki R, Pastan RI, Gamou S and Shimizu N: High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines. Cancer Res 46: 414-416, 1986.
14. Eisbruch A, Blick M, Lee JS, Sacks PG and Gutterman J: Analysis of the epidermal growth factor receptor gene in fresh human head and neck tumors. Cancer Res 47: 3603-3605, 1987.
15. Rubin Grandis J, Zeng Q and Tweardy DJ: Retinoic acid ' normalizes the increased gene transcription rate of TGF-α and EGFR in head and neck cancer. Nat Med 2: 237-240, 1996.
16. Boyle JO, Hakim J, Koch W, van der Riet P, Hruban RH, Roa RA, Correo R, Eby YJ, Ruppert M and Sidransky D: The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res 53: 4477-4480, 1993.
17. Brennan JA, Mao L, Hruban RH, Boyle JO, Eby YJ, Koch WM, Goodman SN and Sidransky D: N Engl J Med 332: 429-435, 1995.
18. Lavieille JP, Brambilla E, Riva-Lavieille C, Reyt E, Charachon R and Brambilla C: Immunohistochemical detection of p53 protein in preneoplastic lesions and squamous cell carcinoma of the head and neck. Acta Otolaryngol 115: 334-339, 1995.
19. Sefo E, Usheva A, Zambetta GP, Momand J, Horikoshi N, Weinmann R, Levine AJ and Sheak T: Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc Natl Acad Sci USA 89: 12028-12032, 1992.
20. Yin X, Smith ML, Whiteside TL, Johnson JT, Herberman RB and Locker J: Abnormalities in the p53 gene in tumors and cell lines of human squamous-cell carcinomas of the head and neck. Int J Cancer 54: 322-327, 1993.
21. Martinez J, Georgoff I, Martinez J and Levine AJ: Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev 5: 151-159, 1991.
22. Wingo PA, Tang T and Bolden S: Cancer statistics, 1995. CA Cancer J Clin 45: 8-30, 1995.
23. Jones AS, Morar P, Phillips DE, Fields JK, Husband D and Helliwell TR: Second primary tumors in patients with head and neck squamous cell carcinoma. Cancer 75: 1343-1353, 1995.
24. Renan MJ: How many mutations are required for tumorigenesis? Implications for human cancer data. Mol Carcinog 7: 139-146, 1993.
25. Shin DM, Kim J, Ro JY, Hittelman J, Roth JA, Hong WK and Hittelman WN: Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis. Cancer Res 54: 321-326, 1994.
26. Melhem MF, Law JC, El-Ashmawy L, Johnson JT, Landreneau RJ, Srivastava S and Whiteside TL: Assessment of sensitivity and specificity of immunohistochemical staining of p53 in lung and head and neck cancers. Am J Pathol 146: 1170-1177, 1995.
27. Deb SP, Munoz RM, Brown DR, Subler MA and Deb S: Wild-type human p53 activated the human epidermal growth factor receptor promoter. Oncogene 9: 1341-1349, 1994.