Effect of protease class-specific inhibitors on in vitro development of the third- to fourth-stage larvae of Ascaris suum

Journal of Parasitology

Volumn 84, Issue 4, 1998, Pages 686-690

  Rhoads, M L ^a   Fetterer, R H ^a   Urban Jr , J F ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE INHIBITOR; PEPSTATIN; PROTEINASE INHIBITOR;

ARTICLE; ASCARIS SUUM; LARVA; MOLTING; NONHUMAN; PARASITE DEVELOPMENT; PROTEINASE INHIBITION;

ANIMALS; ANTI-BACTERIAL AGENTS; ASCARIS SUUM; COLORING AGENTS; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; KETONES; LARVA; MOVEMENT; PEPSTATINS; PEPTIDES; PROTEASE INHIBITORS; SULFONES; SWINE; TETRAZOLIUM SALTS; THIAZOLES; TRYPSIN INHIBITORS;

ASCARIS SUUM; NEMATODA;

EID: 0031846843     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.2307/3284570     Document Type: Article

References (21)

1. BARRETT, A. J. 1980. Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates. Biochemical Journal 187: 909-912.
2. BIRD, A. F. AND J. BIRD. 1991. The structure of nematodes, 2nd ed. Academic Press, San Diego, California, 316 p.
3. BROOKHART, G. L., AND K. J. KRAMER. 1990. Proteinases in molting fluid of the tobacco hornworm, Manduca secta. Insect Biochemistry 20: 467-477.
4. COMLEY, J. C. W., M. J. REES, AND A. B. O'DowD. 1988. The applicability of biochemical criteria to the assessment of macrofilarial viability. Tropical Medicine and Parasitology 39: 456-459.
5. DOUVRES, F. W., G. M. MALAKATIS, AND F. TROMBA. 1969. Morphogenesis and migration of Ascaris suum larva developing to the fourth stage in swine. Journal of Parasitology 55: 689-712.
6. GAMBLE, H. R., J. P. PURCELL, AND R. H. FETTERER. 1989. Purification of a 44 kilodalton protease which mediates the ecdysis of infective Haemonchus contortus larvae. Molecular and Biochemical Parasitology 33: 49-58.
7. HONG, X., J. BOUVIER, M. M. WONG, G. Y. L. YAMAGATA, AND J. H. MCKERROW. 1993. Brugia pahangi: Identification and characterization of an aminopeptidase associated with larval molting. Experimental Parasitology 76: 127-133.
8. LUSTIGMAN, S., B. BROTMAN, T. HUIMA, A. M. PRINCE, AND J. H. MCKERROW. 1992. Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus. Journal of Biological Chemistry 267: 17339-17346.
9. _, J. H. MCKERROW, K. SAH, J. LUI, T. HUIMA, M. HOUGH, AND B. BROTMAN. 1997. Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae. Journal of Biological Chemistry 271: 30181-30189.
10. MCKERROW, J. H. 1994. Cysteine proteases of parasites: A remarkable diversity of function. Perspectives in Drug Discovery and Design 2: 437-444.
11. RASNICK, D. 1985. Synthesis of peptide fluoromethyl ketones and the inhibition of human cathepsin B. Analytical Biochemistry 149: 461-465.
12. RHOADS, M. L., R. H. FETTERER, AND J. F. URBAN, J. F. 1997. Secretion of an aminopeptidase during transition of third-to fourth-stage larvae of Ascaris suum. Journal of Parasitology 83: 780-784.
13. RICH, D. H., B. J. MOON, AND S. HARBESON. 1984. Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes. Journal of Medicinal Chemistry 27: 417-422.
14. RICHER, J. K., W. G. HUNT, J. A. SAKANARI, AND R. B. GRIEVE. 1993. Dirofilaria immitis: Effect of fluoromethyl ketone cysteine protease inhibitors on the third- to fourth-stage molt. Experimental Parasitology 76: 221-231.
15. _, J. A. SAKANARI, G. R. FRANK, AND R. B. GRIEVE. 1992. Dirofilaria immitis: Proteases produced by third- and fourth-stage larvae. Experimental Parasitology 75: 213-222.
16. ROGERS, W. P 1982. Enzymes in the exsheathing fluid of nematodes and their biological significance. International Journal for Parasitology 12: 495-502.
17. SAMUELS, R. I., A. K. CHARNLEY, AND S. E. REYNOLDS. 1993a. A cuticle-degrading proteinase from the moulting fluid of the tobacco horn-worm, Manduca sexta. Insect Biochemistry and Molecular Biology 23: 607-614.
18. _, _, AND _. 1993b. An aminopeptidase from the moulting fluid of the tobacco hornworm, Manduca sexta. Insect Biochemistry and Molecular Biology 23: 615-620.
19. SHAW, E. 1990. Cysteinyl proteinases and their selective inactivation. Advances in Enzymology 63: 271-347.
20. _, AND G. D. J. GREEN. 1981. Inactivation of thiol protease with peptidyl diazomethane ketones. In Methods of enzymology, Vol. 80, L. Lorand (ed.). Academic Press, San Diego, California, p. 820-842.
21. URBAN, J. E JR., AND F. W. DOUVRES. 1981. In vitro development of Ascaris suum from third-to fourth-stage larvae and detection of metabolic antigens in multi-well culture systems. Journal of Parasitology 67: 800-806.