ICU sedation: A review of its pharmacology and assessment

Journal of Intensive Care Medicine

Volumn 13, Issue 4, 1998, Pages 174-183

  Hill, Laureen ^a   Bertaccini, Ed ^b   Barr, Juli ^a,b   Geller, Eran ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; ANXIOLYTIC AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; BUTYROPHENONE DERIVATIVE; ETOMIDATE; FENTANYL; FLUMAZENIL; KETAMINE; MORPHINE; NEUROLEPTIC AGENT; OPIATE DERIVATIVE; PETHIDINE; PROPOFOL; SEDATIVE AGENT;

DRUG USE; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; PRIORITY JOURNAL; REVIEW; SEDATION;

EID: 0031846020     PISSN: 08850666     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1489.1998.00174.x     Document Type: Review

References (50)

1. Yeager MP, Glass DD, Neff RK, et al. Epidural anesthesia and analgesia in high-risk surgical patients. Anesthesiology 1987:66:729-736
2. Smith SM, Brown HO, Toman JEP, et al. The lack of cerebral effects of d-tubocurarine. Anesthesiology 1947;8:1-14
3. Spencer ML. Post-traumatic stress disorder and paralytic agents. Can Nurse 1995; 91(5):19-22
4. Weissman C, Kemper M. Stressing the critically ill patient: the cardiopulmonary and metabolic response to an acute increase in oxygen consumption. J Grit Care 1993:8:100-108
5. Boyd O, Grounds M, Bennett D. The dependency of oxygen consumption on oxygen delivery in critically ill postoperative patients is mimicked by variations in sedation. Chest 1992;101:1619-1624
6. Klein P, Kemper M, Weissman C, et al. Attenuation of the hemodynamic responses to chest physical therapy. Chest 1988;93:38-42
7. Loper KA, Butler S, Nessly M, et al. Paralyzed with pain: the need for education. Pain 1989;37:315-316
8. Ramsay M, Savege T, Simpson B, et al. Controlled sedation with alphaxolone-alphadolone. Br Med J 1974;2:656-659
9. Chernik DA, Gillings D, Laine H, et al. Validity and reliability of the observer's assessment of alertness/sedation scale: study with intravenous midazolam. J Clin Psychopharmacol 1990:10:244-251
10. Schwender D, Daunderer M, Klasing S, et al. Monitoring intraoperative awareness. Vegetative signs, isolated forearm technique, electroencephalogram, and acute evoked potentials. Anaesthetist 1996;45:708-721
11. Mandema JW, Danhof M. Electroencephalogram effect measure and relationships between pharmacokinetic and pharmacodynamics of centrally acting drugs. Clin Pharmacokinet 1992;23:191-215
12. Scott JC, Poganis KV, Stanski DR. EEC quantification of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil. Anesthesiology 1985:62:234-241
13. Buhrer M, Maitre PO, Crevoisier C, et al. Electroencephalographic effects of benzodiazepines, II: pharmacodynamic modeling of the electroencephalographic effects of midazolam and diazepam. Clin Pharmacol Ther 1990;48:555-567
14. Stanski DR, Hudson RJ, Homer TD, et al. Pharmacodynamic modeling of thiopental anesthesia. J Pharmacokinet Biopharm 1984;12:223-236
15. Sigl JC, Chamoun NB. An introduction to bispectral analysis for the electroencephalogram. J Clin Monit 1994; 10:392-404
16. Avramov MN, White PF. Methods for monitoring the level of sedation. Crit Care Clin 1995; 11:803-826
17. Levy WL, Shapiro HM, Maruchk G, et al. Automated EEG processing for intraoperative monitoring: a comparison of techniques. Anesthesiology 1980;53:223-236
18. Spencer EM, Green JL, Willatts SM. Continuous monitoring of depth of sedation of EEG spectral analysis in patients requiring mechanical ventilation. Br J Anaesth 1994;73: 649-654
19. Gregg KM, Varvel JR, Shafer SL. Application of semilinear canonical correlation to the measurement of opioid drug effect. J Pharmacokinet Biopharm 1992;20:611-635
20. Shafer SL, Varvel JR. Pharmacokinetics, pharmacodynamics, and rational opioid selection. Anesthesiology 1991;74:53-63
21. Flacke JW, Flacke WE, Bloor BC, et al. Histamine release by four narcotics: a double-blind study in humans. Anesth Analg 1987;66:723-730
22. Westmoreland CL, Hoke JF, Sebel PS, et al. Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery. Anesthesiology 1993;79:893-903
23. Bowdle TA, Camporesi EM, Maysick L, et al. A multicenter evaluation of remifentanil for early postoperative analgesia. Anesth Analg 1996;83:1292-1297
24. Hoffman RS. An effective strategy for managing cocaine-induced agitated delirium. J Grit Illness 1994;9:139-l49
25. Turner RC, Lichstein PR, Peden JG Jr, et al. Alcohol withdrawal syndromes: a review of pathophysiology, clinical presentation, and treatment. J Gen Intern Med 1989;4: 432-444
26. Ariano RE, Kassum DA, Aronson KJ. Comparison of sedative recovery time after midazolam versus diazepam administration. Grit Care Med 1994;22:1492-1496
27. Bertaccini E, Geller E. Benzodiazepine antagonists and their role in anesthesia and critical care. Anaesth Pharmacol Rev 1995;3:74-81
28. Pepperman ML. Double-blind study of the reversal of midazolam-induced sedation in the intensive care unit with flumazenil (Ro 15-1788): effect on weaning from ventilation. Anaesth Intensive Care 1990;18:38-44
29. Ritz R, Zuber M, Elsasser S, et al. Use of flumazenil in intoxicated patients with coma. A double-blind placebo-controlled study in ICU. Intensive Care Med 1990; 16:242-247
30. Breheny FX. Reversal of midazolam sedation with flumazenil. Grit Care Med 1992;20:736-739
31. Ewen A, Archer DP, Samanani N, et al. Hyperalgesia during sedation: effects of barbiturates and propofol in the rat. Can J Anaesth 1995;42:532-540
32. Stanski DR, Mihm FG, Rosenthal MH, et al. Pharmacokinetics of high-dose thiopental used in cerebral resuscitation. Anesthesiology 1980;53:169-171
33. Dodam JR, Kruse-Elliott KT, Aucoin DP, et al. Duration of etomidate-induced adrenocortical suppression during surgery in dogs. Am J Vet Res 1990;51:786-788
34. Weber MM, Lang J, Abedinpour F, et al. Different inhibitory effect of etomidate and ketoconazole on the human adrenal steroid biosynthesis. Clin Invest 1993;71:933-938
35. Barr J. Propofol: a new drug for sedation in the intensive care unit. Int Anesth Clin 1995;33:131-154
36. Beller JP, Pottecher T, Lugnier A, et al. Prolonged sedation with propofol in ICU patients: recovery and blood concentration changes during periodic interruptions in infusion. Br J Anesth 1988;61:583-588
37. Bevan JC. Propofol-related convulsions. Can J Anesth 1993; 40:805-809
38. Moritz F, Petit J, Kaeffer N, et al. Metabolic effects of propofol and flunitrazepam given for sedation after aortic surgery. Br J Anaesth 1993;70:451-453
39. Cheng DC, Karski J, Peniston C, et al. Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial. J Thorac Cardiovasc Surg 1996;112:755-764
40. Bennett SN, McNeil MM, Bland La, et al. Postoperative infec- lions traced to contamination of an intravenous anesthetic, propofol. N Engl J Med 1995;33:147-154
41. Postsurgical infections associated with an extrinsically contaminated intravenous anesthetic agent - California, Illinois, Maine, Michigan, 1990. MMWR 1990 39(25):426 - 427,433
42. Strickland RA, Murray MJ. Fatal metabolic acidosis in a pediatric patient receiving an infusion of propofol in the intensive care unit: Is there a relationship? Crit Care Med 1995;23: 405-409
43. White PF, Way WL, Trevor AJ. Ketamine: its pharmacology and therapeutic uses. Anesthesiology 1982;56:119-136
44. Stanley TH. Blood pressure and pulse rate responses to ketarnine during general anesthesia. Anesthesiology 1973; 39:648-649
45. Traber DL, Wilson RD, Priano LL. Blockade of the hypertensive response to ketarnine. Anesth Analg 1970;49:420-426
46. Youssef-Ahmed MZ, Silver P, Nimkoff L, et al. Continuous infusion of ketamine in mechanically ventilated children with refractory bronchospasm. Intensive Care Med 1996; 22: 972-976
47. Thurston TA, Mathew BP. In vitro myocardial depression by ketamine or thiopental is dependent on the underlying beta-adrenergic tone. Acta Anaesthesiol Scand 1996;40:338-341
48. Simon P, Panissaud C, Costentin J. Anxiogenic-like effects induced by stimulation of dopamine receptors. Pharmacol Biochem Behav 1993;45:685-690
49. Okamura T, Toda N. Comparison of the effect of dopamine in primate arteries and veins. Hypertens Res 1995;18(suppl 1):S35-S37
50. Faigel DO, Metz DC, Kochman ML. Torsade de pointes complicating the treatment of bleeding esophageal varices: association with neuroleptics, vasopressin, and electrolyte imbalance. Am J Gastroenterol 1995;90:822-824