K1115 A, a new anthraquinone derivative that inhibits the binding of activator protein-1 (AP-1) to its recognition sites. I. Biological activities

Journal of Antibiotics

Volumn 51, Issue 6, 1998, Pages 539-544

  Goto, Masaki ^a   Masegi, Masa Aki ^a   Yamauchi, Toshihiko ^a   Chiba, Ken Ichi ^a   Kuboi, Yoshikazu ^a   Harada, Koukichi ^a   Naruse, Nobuaki ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAQUINONE DERIVATIVE; ANTIINFLAMMATORY AGENT; COLLAGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; K 1115 A; OLIGONUCLEOTIDE; ORNITHINE DECARBOXYLASE; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; STREPTOMYCES; SYNOVIOCYTE;

STREPTOMYCES GRISEORUBIGINOSUS;

EID: 0031845943     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.51.539     Document Type: Article

References (17)

1. LEE, W.; A. HASLINGER, M. KARIN & R. TJIAN: Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40, Nature (London) 325: 368-372, 1987
2. ANGEL, P.; I. BAUMANN, B. STEIN, H. DELIUS, H. J. RAHMSDORF & P. HERRLICH: 12-O-Tetradecanoyl-phorbol-13-acetate (TPA) induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5′-flanking region. Mol. Cell Biol. 7: 2256-2266, 1987
3. HICKOK, N. J.; J. WAHLFORS, A. CROZAT, M. HALMEKYTO, L. ALHONEN, J. JANNE & O. A. JANNE: Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudo gene. Gene 93: 257-263, 1990
4. ANGEL, P. & M. KARIN: The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072: 129-157, 1991
5. SUTO, M. J. & L. J. RANSONE: Novel approaches for the treatment of inflammatory diseases: Inhibitors of NF-κB and AP-1. Current Pharmaceutical Design 3: 515-528, 1997
6. NARUSE, N.; M. GOTO, Y. WATANABE, T. TERASAWA & K. DOBASHI: K1115 A, a new anthraquinone able to inhibit the action of activator protein-1 (AP-1) to its recognition sites. II. Taxonomy, fermentation, isolation, physico-chemical properties and structure determination. J. Antibiotics 51: 545-552, 1998
7. VINCENTI, M. P.; T. A. BURRELL & S. M. TAFFET: Regulation of NF-κB activity in murine macrophages effect of bacterial lipopolysaccharide and phorbol ester. J. Cell Biol. 150: 204-213, 1992
8. 2 production in rats. Eur. J. Biochem. 236: 517-522, 1996
9. GOTO, M.; K. YAMADA, K. KATAYAMA & I. TANAKA: Inhibitory effect of E3330, a novel quinone derivative able to suppress tumor necrosis factor-α generation, on activation of nuclear factor-κB. Mol. Pharmacol. 49: 860-873, 1996
10. HASHIDA, R.; K. TERATO, K. MIYAMOTO, T. MORIMOTO, H. HORI & Y. NAGAI: Effect of polymorphonuclear leukocytes on synovial cell collagenase production. Biomedical Res. 3: 506-516, 1982
11. MOSMANN, T.: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63, 1983
12. O'NEILL, L. A. J.: Towards an understanding of the signal transduction pathways for interleukin 1. Biochim. Biophys. Acta 1266: 31-44, 1995
13. O'BRIEN, T. G.; R. C. SIMSIMAN & R. K. BOUTWELL: Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents. Cancer Res. 35: 1662-1670, 1975
14. ADAMS, J. & R. STEIN: Novel inhibitors of the proteasome and their therapeutic use in inflammation. Annual Reports in Medicinal Chemistry 31: Chapter 28. 279-288, 1996
15. TANIOUS, F. A.; T. C. JENKINS, S. NEIDLE & W. D. WILSON: Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs. Biochemistry 31: 11632-11640, 1992
16. JONAT, C.; H. J. RAHMSDORF, K.-K. PARK, A. C. B. CATO, S. GEBEL, H. PONTA & P. HERRICH: Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62: 1189-1204, 1990
17. SCHULE, R.; P. RANGARAJAN, N. YANG, S. KLIEWER, L. J. RANSONE, J. BOLADO, I. M. VERMA & R. M. EVANS: Retinoic acid is a negative regulator of AP-1-responsive genes. Proc. Natl. Acad. Sci. USA 88: 6092-6096, 1991