PTX-sensitive G proteins and permissive action of prostacyclin in newborn pig cerebral circulation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 1 44-1, 1998, Pages

  Zucker, Boruch ^a   Leffler, Charles W ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Adenosine 3',5' cyclic monophosphate; Cerebrovascular circulation; Epoxyeicosatrienoic acids; Hypercapnia; Protein kinase C

Indexed keywords

5,6 EPOXY 8,11,14 ICOSATRIENOIC ACID; ADENYLATE CYCLASE; CYCLIC AMP; CYSTEINE; GUANINE NUCLEOTIDE BINDING PROTEIN; ILOPROST; INDOMETACIN; PERTUSSIS TOXIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PROSTACYCLIN; PROTEIN KINASE C;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD VESSEL DIAMETER; BRAIN MICROCIRCULATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HYPERCAPNIA; NEWBORN; NONHUMAN; PIA MATER; PRIORITY JOURNAL; SWINE;

EID: 0031845563     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.1.h259     Document Type: Article

References (25)

1. Armstead, W. M., R. Mirro, D. W. Busija, and C. W. Leffler. Permissive role of prostanoids in acetylcholine-induced cerebral vasoconstriction. J. Pharmacol. Exp. Ther. 251: 1012-1019, 1989.
2. Bito, L. Z., and E. V. Salvador. Effects of antiinflammatory agents and some other drugs on prostaglandin biotransport. J. Pharmacol. Exp. Ther. 198: 481-488, 1976.
3. Blayney, L. M., P. W. Gapper, and A. C. Newby. Phospholipase C isoforms in vascular smooth muscle and their regulation by G-proteins. Br. J. Pharmacol. 118: 100-1011, 1996.
4. 2-adrenoceptor-mediated dilations in rat cerebral arteries. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H1171-H1174, 1995.
5. Farrell, D. M., and V. S. Bishop. Permissive role for nitric oxide in active thermoregulatory vasodilation in rabbit ear. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H1613-H1618, 1995.
6. Graser, T., and P. M. Vanhoutte. Hypoxic contraction of canine coronary arteries: role of endothelium and cGMP. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H1769-H1777, 1991.
7. Iadecola, C., and F. Zhang. Permissive and obligatory roles of NO in cerebrovascular responses to hypercapnia and acetylcholine. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R990-R1001, 1996.
8. Iadecola, C., F. Zhang, and X. Su. SIN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R228-R235, 1994.
9. 2+ and GTPγ S. Eur. J. Pharmacol. 207: 189-194, 1991.
10. Jacobowitz, O., and R. Iyenger. Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2. Proc. Natl. Acad. Sci. USA 91: 10630-10634, 1994.
11. Leffler, C. W. Nitric oxide in control of the cerebral circulation. In: Nitric Oxide and the Regulation of the Peripheral Circulation, edited by P. J. Kadowitz and D. B. McNamara. Boston, MA: Birkhauser. In press.
12. Leffler, C. W. Prostanoids: intrinsic modulators of cerebral circulation. News Physiol. Sci. 12: 72-77, 1997.
13. Leffler, C. W., W. M. Armstead, and M. Shibata. Role of eicosanoids in cerebral hemodynamics. In: The Regulation of Cerebral Blood Flow, edited by J. W. Phillis. Boca Raton, FL: CRC, 1993, chapt. 9, p. 217-313.
14. Leffler, C. W., and D. W. Busija. Prostanoids in cortical subarachnoid cerebrospinal fluid and pial artery diameter in newborn pigs. Circ. Res. 57: 689-694, 1985.
15. Leffler, C. W., and A. L. Fedinec. Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H333-H338, 1997.
16. Leffler, C. W., R. Mirro, L. J. Pharris, and M. Shibata. Permissive role of prostacyclin in cerebral vasodilation to hypercapnia in newborn pigs. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H285-H291, 1994.
17. Leffler, C. W., R. Mirro, D. R. Shanklin, W. M. Armstead, and M. Shibata. Light/dye microvascular injury selectively eliminates hypercapnia-induced pial arteriolar dilation in newborn pigs. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H623-H630, 1994,
18. Leffler, C. W., R. Mirro, M. Shibata, H. Parfenova, W. M. Armstead, and S. Zuckerman. Effects of indomethacin on cerebral vasodilator responses to arachidonic acid and hypercapnia in newborn pigs. Pediatr. Res. 33: 609-614, 1993.
19. Parfenova, H., P. Hsu, and C. W. Leffler. Dilator prostanoid induced cyclic-AMP formation and release by cerebral microvascular smooth muscle cells: inhibition by indomethacin. J. Pharmacol. Exp. Ther. 272: 44-52, 1995.
20. αi3 protein. Regul. Pept. 62: 153-159, 1996.
21. Quick, M. W., M. I. Simon, N. Davidson, H. A. Lester, and A. M. Aragay. Differential coupling of G protein α subunits to seven helix receptors expressed in Xenopus oocytes. J. Biol. Chem. 269: 30164-30172, 1994.
22. Rama, G. P., H. Parfenova, and C. W. Leffler. Protein kinase Cs and tyrosine kinases in permissive action of prostacyclin on cerebrovascular regulation in newborn pigs. Pediatr. Res. 41: 83-89, 1997.
23. Simon, M. I., M. P. Strathmann, and N. Gautam. Diversity of G proteins in signal transduction. Science 252: 802-808, 1991.
24. 2-reactivity of cerebral arterioles is restored by dilator prostaglandin. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H1332-H1338, 1994.
25. 2 response in cerebral arterioles of the newborn pig: role of phospholipase, cyclooxygenase, and lipooxygenase pathways. Circ. Res. 62: 1019-1026, 1988.