Hemoglobinopathies affecting maternal-fetal oxygen gradient during pregnancy: Molecular, biochemical and clinical studies

American Journal of Perinatology

Volumn 15, Issue 6, 1998, Pages 389-393

  Bard, Harry ^a,d   Rosenberg, Arthur ^b   Huisman, Titus H J ^c  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Fetal Hb O2 affinity; Hemoglobinopathies; Maternal fetal O2 affinity gradient

Indexed keywords

2,3 DIPHOSPHOGLYCERIC ACID; ERYTHROPOIETIN; HEMOGLOBIN F; HEMOGLOBIN VARIANT;

ADULT; ARTICLE; CASE REPORT; FEMALE; FETUS; FETUS BLOOD; HEMOGLOBINOPATHY; HETEROZYGOTE; HUMAN; MATERNAL BLOOD; NEWBORN; OXYGEN AFFINITY; OXYGEN DISSOCIATION CURVE; PLACENTAL TRANSFER; PREGNANCY; PRIORITY JOURNAL;

EID: 0031845279     PISSN: 07351631     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-993963     Document Type: Article

References (20)

1. Charache S, Catalano P, Burns S, et al. Pregnancy in carriers of high-affinity hemoglobins. Blood 1985;65:713-718
2. Parer JT. Reversed relationship of oxygen affinity in maternal and fetal blood. Am J Obstet Gynecol 1970;108:323-325
3. Adamson JW, Parer JT, Stamatoyannopoulos G. Erythrocytosis associated with hemoglobin Rainier: Oxygen equilibria and marrow regulation. J Clin Invest 1969;48:1376-1386
4. Kitanaka T, Alonso JG, Gilbert RD, et al. Fetal responses to long-term hypoxemia in sheep. Am J Physiol 1989;R1348-R1354
5. Bard H, Fouron JC, Prosmanne J, Gagnon J. Effect of hypoxemia on fetal hemoglobin synthesis during late gestation. Pediatr Res 1992;31:483-485
6. Bromberg YM, Abrahamov AM, Salzverger M. The effect of maternal anoxaemia on the foetal hemoglobin of the newborn. J Obstet Br Emp 1956;63:875-877
7. Bard H. The effect of placental insufficiency on fetal and adult hemoglobin synthesis. Am J Obstet Gynecol 1974; 120:67-72
8. Bard H, Teasdale F. Red cell oxygen affinity, hemoglobin type, 2,3-diphosphoglycerate, and pH as a function of fetal development. Pediatrics 1979;64:483-487
9. Bard H. The postnatal decline of hemoglobin F synthesis in normal full-term infants. J Clin Invest 1975;55:395-398
10. Shelton JB, Shelton JR, Schroeder JA. High performance liquid chromatographic separation of globin chains on a large-pore C4 column. J Liq Chromarogr 1984;7:1969-1977
11. Divoky V, Bissé E, Wilson JB, et al. Heterozygosity for the IVS-1-5 (GÆC) mutation with a GÆA change at codon 18 (ValÆMet; Hb Baden) in cis and a TÆG mutation at codon 126 (ValÆGly; Hb Dhonburi) in trans resulting in a thalassemia intermedia. Biochim Biophys Acta 1992; 1180:173-179
12. 2 (94 (G1) Asp→His}β2 Hemoglobin 1979; 3:145-159
13. Naiman JL. Normal blood values in the newborn period. In Oski FA, Naiman JL (eds): Hematologic problems in the newborn. Toronto: Saunders; 1972: p 15
14. Ireland R, Abbas A, et al. Fetal and maternal erythropoietin levels in normal pregnancy. Fetal Diagn Ther 1991;7:21-25
15. Bureau MA, Shapcott D, Berthiaume Y, et al. Maternal cigarette smoking and fetal oxygen transport: A study of P50, 2,3-Diphosphoglycerate, total hemoglobin, hematocrit, and type F hemoglobin in fetal blood. Pediatrics 1983; 72:22-26
16. Novy MJ, Parer JT. Absence of high blood oxygen affinity in the fetal cat. Resp Physiol 1969;6:144-150
17. Huehns ER, Farooqui AM. Oxygen dissociation properties of human embryonic red cells. Nature 1975;254:335-337
18. Hebbel RP, Berger EM, Eaton JW. Effect of increased maternal hemoglobin oxygen affinity on fetal growth in the rat. Blood 1980;55:969-974
19. Cotes PM, Spivak JL. Erythropoietin in health and disease. In Ersley AJ, Adamson JW, Eschbach JW, Winearls CG (eds): Erythropoietin. Molecular, cellular and clinical biology. Baltimore: The Johns Hopkins University Press; 1991: pp 184-207
20. Wilkening RB, Molina RD, Meschia G. Placental oxygen transport in sheep with different hemoglobin types. Am J Physiol 1988;254:R585-R589