Double-labeled immunofluorescence study of cutaneous nerves in psoriasis

International Journal of Dermatology

Volumn 37, Issue 8, 1998, Pages 572-574

  Jiang, Wen Yue ^a   Raychaudhuri, Siba P ^a   Farber, Eugene M ^a  

^a Psoriasis Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; NEUROPEPTIDE; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ARTICLE; ENDOTHELIUM CELL; EPIDERMIS CELL; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; KERATINOCYTE; MITOGENICITY; NERVE BIOPSY; NEUTROPHIL CHEMOTAXIS; PSORIASIS; SKIN BIOPSY; SKIN NERVE; T LYMPHOCYTE ACTIVATION;

CALCITONIN GENE-RELATED PEPTIDE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NERVE FIBERS; NEURONS, AFFERENT; PSORIASIS; SKIN; SUBSTANCE P; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0031844812     PISSN: 00119059     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-4362.1998.00533.x     Document Type: Article

References (17)

1. Farber EM, Nickoloff BJ, Recht B, et al. Stress, symmetry, and psoriasis: possible role of neuropeptides. J Am Acad Dermatol 1986; 14: 305-311.
2. Raychaudhuri SP, Farber EM. Are sensory nerves essential for the pathogenesis of psoriasis? J Am Acad Dermatol 1993; 28: 488-489.
3. Naukarinen A, Nickoloff BJ, Farber EM. Quantification of cutaneous sensory nerves and their substance P content in psoriasis. J Invest Dermatol 1989; 92: 126-119.
4. Al'Abadie MSK, Senior HJ, Bleehen SS, et al. Neurogenic changes in psoriasis: an immunohistochemical study. J Invest Dermatol 1992; 98: 535.
5. Naukkarinen A, Harvima I, Paukkonen K, et al. Immunohistochemical analysis of sensory nerves and neuropeptides, and their contacts with mast cells in developing and mature psoriatic lesions. Arch Dermatol Res 1993; 285: 341-346.
6. Farber EM, Lanigan SW, Boer J. The role of cutaneous nerves in the maintenance of psoriasis. Int J Dermatol 1990; 29: 418-420.
7. Pincelli C, Fantini F, Romualdi P, et al. Substance P is diminished and vasoactive intestinal peptide is augmented in psoriatic lesions and these peptides exert disparate effects on the proliferation of cultured human keratinocytes. J Invest Dermatol 1992; 98: 421-427.
8. Eedy DJ, Johnston CF, Shaw C, et al. Neuropeptides in psoriasis: an immunocytochemical and radioimmunoassay study. J Invest Dermatol 1991; 96: 434-438.
9. Matis WL, Lavker RM, Murphy GF. Substance P induces the expression of an endothelial-leukocyte adhesion molecule by microvascular endothelium. J Invest Dermatol 1990; 94: 492-495.
10. Rameshwar P, Gascon P, Ganea D. Immunoregulatory effects of neuropeptides. Stimulation of IL-2 production by substance P. J Neuroimmunol 1992; 37: 65-74.
11. Wilkinson DI. Mitogenic effect of substance P and CGRP on keratinocytes. J Cell Biol 1989; 107: 509a.
12. Church MK, Lowman MA, Robinson C, et al. Interaction of neuropeptides with human mast cells. Int Arch Allergy Appl Immunol 1989; 88: 70-75.
13. Bienenstock J, Tomioka K, Matsuda H, et al. The role of mast cells in inflammatory processes: evidence for nerve/ mast cell interactions. Int Arch Allergy Appl Immunol 1987; 82: 238-243.
14. Smith HC, Barker JN, Morris RW, et al. Neuropeptides induce rapid expression of endothelial cell adhesion molecules and elicit granulocytic infiltration in human skin. J Immunol 1993; 151: 3274-3282.
15. Fantini F, Magnoni C, Brauci-Laudeis L, Pincelli C. Nerve growth factor is increased in psoriatic skin. J Invest Dermatol 1995; 105: 854-855.
16. Farber EM, Chan J, Raychaudhuri SP, et al. Increased nerve growth factor (NGF-R) in papillary dermis of lesional psoriatic skin: further evidence for role of the sensory nervous systems in the pathogenesis of psoriasis. Br J Dermatol 1996; 135: 841.
17. Lindsay RM, Harmar AJ. Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons. Nature 1989; 337: 362-364.