High incidence of primary pulmonary hypertension associated with appetite suppressants in Belgium

European Respiratory Journal

Volumn 12, Issue 2, 1998, Pages 271-276

  Delcroix, M ^a   Kurz, X ^c   Walckiers, D ^c   Demedts, M ^a   Naeije, R ^b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c Institute of Hygiene and Epidemiology of Brussels   (Belgium)

Author keywords

Appetite suppressants; Fenfluramines; Primary pulmonary hypertension

Indexed keywords

AMFEPRAMONE; ANOREXIGENIC AGENT; DEXFENFLURAMINE; FENFLURAMINE; PHENTERMINE;

ADULT; AGED; ARTICLE; BELGIUM; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INCIDENCE; LUNG ARTERY PRESSURE; MALE; PRESCRIPTION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SURVIVAL;

EID: 0031844306     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.98.12020271     Document Type: Article

References (20)

1. Rubin LJ. Primary pulmonary hypertension. N Engl J Med 1997; 336: 111-117.
2. Gurtner HP. Aminorex pulmonary hypertension (chapter 29). In: Fishman AP, ed. The Pulmonary Circulation, Normal and Abnormal. Philadelphia, University of Pennsylvania Press, 1990; pp. 397-411.
3. Brenot F, Herve P, Petitpretz P, Parent F, Duroux P, Simonneau G. Primary pulmonary hypertension and fenfluramine use. Br Heart J 1993; 70: 537-541.
4. Abenhaim L, Moride Y, Brenot F, et al. Appetite-suppressant drugs and the risk of primary pulmonary hypertension. N Engl J Med 1996; 335: 609-616.
5. Manson JE, Faich GA. Pharmacotherapy for obesity - do the benefits outweigh the risk? N Engl J Med 1996; 335: 659-660.
6. Voelkel NF, Clarke WR, Higenbottam T. Obesity, dexfenfluramine, and pulmonary hypertension. A lesson not learned? Am J Respir Crit Care Med 1997; 155: 786-788.
7. Rich S, Dantzker DR, Ayres SM, et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med 1987; 107: 216-223.
8. Armitage P, Berry G. Statistical Methods in Medical Research. Oxford, Blackwell Scientific Publications, 1987; pp. 104-115.
9. Thomas SHL, Butt AY, Corris PA, et al. Appetite suppressants and primary pulmonary hypertension in the United Kingdom. Br Heart J 1995; 74: 660-663.
10. Pinder RM, Brogden RN, Sawyer PR, Speight TM, Avery GS. Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity. Drugs 1975; 10: 241-323.
11. McTavish D, Heel RC. Dexfenfluramine. A review of its pharmacological properties and therapeutic potential in obesity. Drugs 1992; 43: 713-733.
12. Fristrom S, Airaksinen MM, Halmekoski J. Release of platelet 5-hydroxytryptamine by some anorexic and other sympathomimetics and their acetyl derivatives. Acta Pharmacol Toxicol Copenh 1977; 41: 218-224.
13. Hervé P, Launay JM, Scrobohaci ML, et al. Increased plasma serotonin in primary pulmonary hypertension. Am J Med 1995; 99; 249-254.
14. Naeije R, Wauthy P, Maggiorini M, Leeman M, Delcroix M. Effects of dexfenfluramine on hypoxic pulmonary vasoconstriction and embolie pulmonary hypertension in dogs. Am J Respir Crit Care Med 1995; 151: 692-697.
15. Weir EK, Reeve HL, Huang JMC, et al. Anorectic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. Circulation 1996; 94: 2216-2220.
16. Guy-Grand B, Apfelbaum M, Crepaldi G, Gries A, Lefebvre P, Turner P. International trial of long-term dexfenfluramine in obesity. Lancet 1989; ii: 1142-1144.
17. Manson JE, Willett WC, Stampfer MJ, et al. Body weight and mortality among women. N Engl J Med 1995; 333: 677-685.
18. Pfohl M, Luft D, Blomberg I, Schmülling RM. Long-term changes of body weight and cardiovascular risk factors after weight reduction with group therapy and dexfenfluramine. Int J Obes 1994; 18: 391-395.
19. O'Connor HT, Richman RM, Steinbeck KS, Caterson ID. Dexfenfluramine treatment of obesity: a double blind trial with post trial follow-up. Int J Obes 1995; 19: 181-189.
20. Connolly HM, Crary JL, McGoon MD, et al. Valvular heart disease associated with fenfluramine-phentermine. N Engl Med 1997; 337: 581-588.