Iron binding and autoreduction by citrate: Are these involved in signalling by iron regulatory protein-1?

Free Radical Research

Volumn 28, Issue 3, 1998, Pages 319-322

  Gutteridge, John M C ^a   Mumby, Sharon ^b   Lamb, Nicholas J ^b  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Iron autoreduction; Iron binding; Iron regulatory protein; Redox active iron; Signalling

Indexed keywords

ACONITATE HYDRATASE; CITRIC ACID; FERRIC ION; FERROZINE; IRON; IRON COMPLEX; IRON REGULATORY FACTOR;

ARTICLE; ENZYME ACTIVITY; OXIDATION REDUCTION REACTION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 0031842685     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.3109/10715769809069283     Document Type: Article

References (9)

1. Neilands, J. B. (1972). Evolution of biological iron binding centers. Structure and Bonding, 11, 145-170.
2. Baker, M. S. and Gebicki, J. M. (1986). The effect of pH on yields of hydroxyl radicals produced from superoxide by potential biological iron chelators. Archives of Biochemistry and Biophysics, 246, 581-588.
3. Gutteridge, J. M. C. (1991). Hydroxyl radical formation from the auto-reduction of a ferric citrate complex. Free Radical Biology and Medicine, 11, 401-406.
4. Paraskeva, E. and Hentze, M. W. (1996). Iron-sulphur clusters as genetic regulatory switches: the bifunctional iron regulatory protein-1. Federation of European Biochemical Societies Letters, 389, 40-43.
5. Kennedy, M. C., Emptage, M. H., Dreyer, J. L. and Beinert, H. (1983). The role of iron in the activation-inactivation of aconitase. The Journal of Biological Chemistry, 258, 11098-11105.
6. Thiel, E. C. (1994). Iron regulatory elements (IRES): a family of mRNA non-coding sequences. Biochemical Journal, 304, 1-11.
7. Fujita, T., Hamasak, H., Fwukata, C. and Nonobe, M. (1994). New enzymatic assay of iron in serum. Clinical Chemistry, 40, 763-767.
8. Mumby, S., Koizumi, M., Taniguchi, N. and Gutteridge, J. M. C. (1997). Reactive iron species in biological fluids activate the iron-sulphur cluster of aconitase. Biochimica et Biophysica Acta, In press.
9. Gutteridge, J. M. C., Mumby, S., Koizumi, M. and Taniguchi, N. (1996). "Free" iron in neonatal plasma activates aconitase: Evidence for biologically reactive iron. Biochemical and Biophysical Research Communications, 229, 806-809.