Bronchodilator delivery by metered-dose inhaler in mechanically ventilated COPD patients: Influence of end-inspiratory pause

European Respiratory Journal

Volumn 12, Issue 1, 1998, Pages 165-169

  Mouloudi, E ^a   Katsanoulas, K ^a   Anastasaki, M ^a   Askitopoulou, E ^a   Georgopoulos, D ^a  

^a UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

Author keywords

Airway resistance; Respiratory system mechanics; Salbutamol

Indexed keywords

BRONCHODILATING AGENT; SALBUTAMOL;

ADULT; AEROSOL; AGED; AIRWAY RESISTANCE; ARTICLE; ARTIFICIAL VENTILATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; HEART RATE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; METERED DOSE INHALER; OXYGEN TENSION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY SYSTEM; TIDAL VOLUME; VENTILATOR;

AGED; AIRWAY RESISTANCE; ALBUTEROL; BRONCHODILATOR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LUNG DISEASES, OBSTRUCTIVE; MALE; MIDDLE AGED; NEBULIZERS AND VAPORIZERS; PULMONARY VENTILATION; RESPIRATION, ARTIFICIAL;

EID: 0031842378     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.98.12010165     Document Type: Article

References (18)

1. Fernandez A, Lazaro A, Garcia A, Aragon C, Cerda E. Bronchodilators in patients with chronic obstructive pulmonary disease on mechanical ventilation: utilisation of metered-dose inhalers. Am Rev Respir Dis 1990; 141: 164-168.
2. Dhand R, Jubran A, Tobin MT. Bronchodilator delivery by metered-dose inhaler in ventilator supported patients. Am J Respir Crit Care Med 1995; 151: 1827-1833.
3. Dhand R, Duarte AG, Jubran A, et al. Dose-response to bronchodilator delivered by metered-dose inhaler in ventilator-supported patients. Am J Respir Crit Care Med 1996; 154: 388-393.
4. Dhand R, Tobin MJ. Bronchodilator delivery with metered dose inhalers in mechanically ventilated patients. Eur Respir J 1996; 9: 585-595.
5. Dhand R, Tobin MJ. Inhaled bronchodilator therapy in mechanically ventilated patients. Am J Respir Crit Care Med 1997; 156: 3-10.
6. Manthous CA, Hall JB, Schmidt GA, Wood LDH. Metered dose inhaler versus nebulized albuterol in mechanically ventilated patients. Am Rev Respir Dis 1993; 148: 1567-1570.
7. Summer W, Elston R, Tharpe L, Nelson S, Haponik EF. Aerosol bronchodilator delivery methods: relative impact on pulmonary function and cost of respiratory care. Arch Intern Med 1989; 149: 618-623.
8. Bowton DL, Goldsmith WM, Haponik EF. Substitution of metered-dose inhalers for hand nebulizers: success and cost-savings in a large, acute care hospital. Chest 1992; 101: 305-308.
9. Alvine GF, Rodgers P, Fitzsimmons KM, Ahrens RC. Disposable jet nebulizers; how reliable are they? Chest 1992; 101: 316-319.
10. Hamill RJ, Houston ED, Georghiu PR, et al. An outbreak of Burkholderia (formerly Pseudomonas) cepacia respiratory tract colonisation and infection associated with nebulized albuterol therapy. Ann Intern Med 1995; 122: 762-766.
11. Gay PC, Patel HG, Nelson SB, Gilles B, Hubmayr RD. Metered dose inhalers for bronchodilator delivery in intubated, mechanically ventilated patients. Chest 1991; 99: 66-71.
12. Siafakas NM, Vermeire P, Pride NB, et al. Optimal assessment and management of chronic obstructive pulmonary disease. ERS - Consensus statement. Eur Respir J 1995; 8: 1398-1420.
13. Prechter CG, Nelson SB, Hubmayr RD. The ventilatory recruitment threshold for carbon dioxide. Am Rev Respir Dis 1990; 141: 758-764.
14. Gottfried SB, Rossi A, Higgs BD, Zocchi L, Grassino A, Milic-Emili J. Respiratory mechanics in mechanically ventilated patients with respiratory failure, J Appl Physiol 1985; 58: 1849-1858.
15. Bates JHT, Rossi A, Milic-Emili J. Analysis of the behaviour of the respiratory system with constant inspiratory flow. J Appl Physiol 1985; 58: 1840-1848.
16. Kochi T, Okubo S, Zin W, Milic-Emili J. Flow and volume dependence of pulmonary mechanics in anaesthetised cats. J Appl Physiol 1988; 64: 441-450.
17. Albert RK, Martin TR, Lewis SW. Controlled clinical trial of methylprednisolone in patients with chronic bronchitis and acute respiratory insufficiency. Ann Intern Med 1980; 92: 753-758.
18. Fink JB, Dhand R, Duarte AG, Jenne JW,Tobin MJ. Deposition of aerosol from metered-dose inhaler during mechanical ventilation: an in vitro model. Am J Respir Crit Care Med 1996; 154: 382-387.