Genetic instability, p53 and nm23 mutation and clinicopathological features in rectal carcinoma

Anticancer Research

Volumn 18, Issue 2 A, 1998, Pages 989-993

  Indinnimeo, Marileda ^a   Cicchini, Claudia ^a   Stazi, Alessandro ^a   Mingazzini, Pietro ^a   Caligo, M Adelaide ^b   Ghimenti, Chiara ^b   Bevilacqua, Generoso ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Microsatellite instability; Prognosis; Rectal cancer; Replication error

Indexed keywords

PROTEIN P53;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BASE MISPAIRING; CLINICAL ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; MALE; MICROSATELLITE INSTABILITY; ONCOGENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; RECTUM CANCER; RECTUM CARCINOMA; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENES, P53; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MONOMERIC GTP-BINDING PROTEINS; MUTATION; NUCLEOSIDE-DIPHOSPHATE KINASE; POLYMERASE CHAIN REACTION; RECTAL NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 0031841777     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Weinberg RA: Oncogenes, anti-oncogenes and the molecular basis of multistep carcinogenesis. Cancer Res 49: 3713-3721, 1989.
2. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61:759-767, 1990.
3. Harwood J, Tachiba A, Meuth M: Multiple dispersed spontaneous mutations: a novel pathway of mutagenesis in a malignant human cell line. Mol Cell Biol 11: 3163-3170, 1991.
4. Loeb LA: Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51: 3075-3079, 1991.
5. Loeb LA: Microsatellite instability: marker of a mutator phenotype in cancer. Cancer Res 54: 5059-5063, 1994.
6. Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M: Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363: 558-561, 1993.
7. Peltomaki P, Lothe RA, Aaltonen LA, Pylkkanen L, Nystrom-Lathi M, Seruca R, David L, Holm R, Ryberg D, Haugen A, Brogger A, Borresen AL, de La Chapelle A: Microsatellite instability is associated with tumors that caracterize the ereditary non-polyposis colorectal carcinoma syndrome. Cancer Res 53: 5853-5855, 1993.
8. Peltomaki P: Microsatellite instability and hereditary non-polyposis colon cancer. J Pathol 176: 329-330, 1995.
9. Richards RI, Sutherland GR: Simple repeat is not replicated simply. Nature Genet 6: 114-116, 1994.
10. Kunkel TA: Slippery DNA and diseases. Nature 365: 207-208, 1993.
11. Fishel R, Lescoe MK, Rao MRS, Copeland NG, Jenkins NA, Garber J, et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colorectal cancer. Cell 75: 1027-1038, 1993.
12. Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, et al: Mutations of a MutS homolog in hereditary non-polyposis colorectal cancer. Cell 75:1 215-1225, 1993.
13. Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK, et al: Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368: 258-261, 1994.
14. Papadopoulos N, Nicolaides NC, Wei Y-F, Ruben SM, Carter KC, Rosen CA, et al: Mutation of a mutL homolog is associated with hereditary colon cancer. Science 263: 1625-1629, 1994.
15. Nicolaides NC, Papadopoulos N, Liu B, Wei Y-F, Carter KC, Ruben SM, et al: Mutations of two mutL homologs, hPMS1 and hPMS2, in hereditary nonpolyposis colon cancer. Nature 371:75-80, 1994.
16. Weissenbach J, Gyapay G, Dib C, Vignal A, Morissette J, Milassedu P et al: A second-generation linkage map of the human genome. Nature (Lond.) 359: 794-801, 1992.
17. Aaltonen LA, Peltomaki P, Leach FS, Sistonen P, Pylkkanen L, Mecklin JP, et al: Clues to the pathogenesis of familial colorectal cancer. Science 260: 812-816, 1993.
18. Thibodeau SN, Bren G, Schaid D: Microsatellite instability in cancer of the proximal colon. Science 260: 816-819, 1993.
19. Lothe RA, Peltomaki P, Meling GI, Aaltonen LA, Nystrom-Lahti M, Pylkkanen L, et al: Genomic instability in colorectal cancer: relationship of clinocopathological variables and family history. Cancer Res 53: 5849-5852, 1993.
20. Nakashima H, Inoue H, Mori M, Neo H, Ikeda M, Akiyoshi T: Microsatellite instability in Japanese gastric cancer. Cancer 75: 1503-1507, 1995.
21. Rhyu MG, Park W, Sand-Meltzer SJ: Microsatellite instability occurs frequently in human gastric carcinoma. Oncogene 9: 29-32, 1994.
22. Strickler JG, Zheng J, Shu Q, Burgart LJ, Alberts SR, Shibata D, et al: p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail. Cancer Res 54: 4750-4755, 1994.
23. Han HJ, Yanagisawa A, Kato Y, Park J-G, Nakamura Y: Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res 53: 5087-5089, 1993.
24. Mironov NM, Aguelon MA-M, Potapova GI, Omori Y, Gorbunov OV, Klimenkov AA, et al: Alterations of (CA)n DNA repeats and tumor suppressor genes in human gastric cancer. Cancer Res 54: 41-44, 1994.
25. Nakashima H, Honda M, Inoue H, Shibata K, Arinaga S, Era S, et al: Microsatellite instability in multiple gastric cancers. Int J Cancer (Pred Oncol) 64: 239-242, 1995.
26. Meltzer SJ, Yin J, Manin B, Rhyu MG, Cottrell J, Hudson E, Redd J, et al: Microsatellite instability occurs frequently and in both diploid and aneuploid cell populations of Barrett's associated esophageal adenocarcinoma. Cancer Res 54: 3379-3382, 1994.
27. Ogasawara S, Maesawa C, Tamura G, Satodate R: Frequent microsatellite alterations on chromosome 3p in esophageal squamous cell carcinoma. Cancer Res 55: 891-894, 1995.
28. Peltomaki P, Aaltonen LA, Sistonen P, Pylkkanen L, Mecklin J-P, Jarvinen H, et al: Genetic mapping of a locus predisposing to human colorectal cancer. Science 260: 810-819, 1993.
29. Shridar V, Siegfried J, Hunt J, del Mar Alonso M, Smith DI: Genetic instability of microsatellite sequences in many non-small cell lung carcinomas. Cancer Res 54: 2084-2087, 1994.
30. Yu S, Pritchard M, Kremer E, Lynch M, Nancarrow J, Baker E, et al: Fragile X genotype characterized by an unstable region of DNA. Science 252: 1179-1181, 1991.
31. Snell RG, MacMillan JC, Cheadle JP, Fenton I, Lazarou LP, Davies P, et al: Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease. Nat Genet 4: 393-397, 1993.
32. Fu YH, Pissuti A, Fenwick RG Jr, King J, Rajnarayan S, Dunne PW, et al: An unstable triplet repeat in a gene related to myotonic muscular dystrophy. Science 255: 1256-1258, 1992.
33. Aaltonen LA, Peltomaki P, Mecklin JP, Jarvinen H, Jass JR, Green JS, et al: Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res 54: 1645-1648, 1994.
34. Keohavong P, Thilly WG: Fidelity of DNA polymerases in DNA amplification. Proc Natl Acad Sci USA 86: 9253-9257, 1989.
35. Horii A, Han HJ, Shimada M, Yanagisawa A, Kato Y, Ohta H, et al: Frequent replication errors at microsatellite loci in tumors of patients with multiple primary cancers. Cancer Res 54: 3373-3375, 1994.
36. Lynch HT, Smyrk TC, Watson P, Lanspa SJ, Lynch JF, Lynch PM, et al: Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology 104: 1535-1549, 1993.
37. Shibata D, Peinado MA, Ionov Y, Malkhosyan S, Perucho M: Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nature Genet 6: 273-281, 1994.
38. Bodmer W, Bishop T, Karran P: Genetic steps in colorectal cancer. Nature Genet 6: 217-219, 1994.
39. Nakashima H, Mori M, Mimori K, Inoue H, Baba K, Shibuta K, et al: Microsatellite instability in Japanese colorectal carcinoma. Oncol Rep 4: 387-389, 1997.
40. Ishimaru G, Adachi JI, Shiseki M, Yamaguchi N, Muto T, Yokota J: Microsatellite instability in primary and metastatic colorectal cancers. Int J Cancer 64: 153-157, 1995.
41. Kim H, Jen J, Vogelstein B, Hamilton SR: Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 145: 148-156, 1994.
42. Benatti P, Sassatelli R, Roncucci L, Pedroni M, Fante R, Di Gregorio C, et al: Tumor spectrum in hereditary non-polyposis colorectal cancer (HNPCC) and in families with "suspected HNPCC". A population-based study in Northen Italy. Int J Cancer 54: 371-377, 1993.
43. Vasen HFA, Offerhaus GJA, Den Hartog Jager FCA, Menko FH, Nagengast FM, Griffionen G, et al: The tumor spectrum in hereditary non-polyposis colorectal cancer: a study of 24 kindreds in the Netherlands. Int J Cancer 46: 31-34, 1990.