Conserved sequences in enzymes of the UDP-GlcNAc/MurNAc family are essential in hamster UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase

Glycobiology

Volumn 8, Issue 6, 1998, Pages 625-632

  Dal Nogare, Anthony R ^a   Dan, Ning ^a,b   Lehrman, Mark A ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b ZHENGZHOU UNIVERSITY   (China)

Author keywords

Dolichol; Glycosyltransferase; Tunicamycin; UDP GlcNAc

Indexed keywords

ALANINE AMINOTRANSFERASE; DOLICHOL; GLYCOSYLTRANSFERASE; TRANSFERASE; URIDINE DIPHOSPHATE GLUCOSE;

AMINO ACID COMPOSITION; ANIMAL CELL; ARTICLE; CHINESE HAMSTER; CHO CELL; ENZYME ACTIVITY; EUKARYOTE; IMMUNOBLOTTING; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROKARYOTE; PROTEIN FOLDING;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; CHO CELLS; CONSERVED SEQUENCE; CRICETINAE; ESCHERICHIA COLI; GENE EXPRESSION; GENE TARGETING; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE SYNTHASES; PROTEIN FOLDING; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

ANIMALIA; BACTERIA (MICROORGANISMS); CRICETINAE; CRICETULUS GRISEUS; EUKARYOTA; PROKARYOTA;

EID: 0031840588     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/8.6.625     Document Type: Article

References (11)

1. Brown, M.S. and Goldstein, J.L. (1997) The SREBP Pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell, 89, 331-340.
2. Datta, A.K. and Lehrman, M.A. (1993) Both potential dolichol recognition sequences of hamster GlcNAc-1-phosphate transferase are necessary for normal enzyme function. J. Biol. Chem., 268, 12663-12668.
3. Dan, N. and Lehrman, M.A. (1997) Oligomerization of hamster UDP-GlcNAc:Dolichol-P GlcNAc-1-P transferase, an enzyme with multiple transmembrane spans. J. Biol. Chem., 212, 14214-14219.
4. Dan, N., Middleton, R.M. and Lehrman, M.A. (1996) Hamster UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase has multiple transmembrane spans and a critical cytosolic loop. J. Biol. Chem., 271, 30717-30725.
5. Lehrman, M.A. (1991) Biosynthesis of N-acetylglucosamine-P-P-dolichol, the committed step of asparagine-linked oligosaccharide assembly. Glycobiology, 1, 553-562.
6. Lehrman, M.A. (1994) A family Of UDP-GlcNAc/MurNAc:polyisoprenol-P GlcNAc/MurNAc-1-P transferases. Glycobiology, 4, 768-771.
7. Lehrman, M.A., Zhu, X. and Khounlo, S. (1988) Amplification and molecular cloning of the hamster tunicamycin-sensitive N-acetylglucosamine-1-phosphate transferase gene: the hamster and yeast enzymes share a common peptide sequence. J. Biol. Chem., 263, 19796-19803.
8. Rush, J.S., Rick, P.D. and Waechter, C.J. (1997) Polyisoprenyl phosphate specificity of UDP-GlcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase from E.coli. Glycobiology, 1, 315-322.
9. Slonina, A.E., Scott, T.C. and Lehrman, M.A. (1993) Gene inactivtion in Lec35.1 (mannosylation-defective) Chinese hamster ovary cells. J. Biol. Chem., 268, 6729-6733.
10. Zhu, X. and Lehrman, M.A. (1990) Cloning, sequence, and expression of acDNA encoding hamster UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1-phosphate transferase. J. Biol. Chem., 265, 14250-14255.
11. Zhu, X., Zeng, Y. and Lehrman, M.A. (1992) Evidence that the hamster tunicamycin resistance gene encodes UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1-phospbate transferase. J. Biol. Chem. 267, 8895-8902.