Theoretical evidence of the existence of a diazafulvene intermediate in the reaction pathway of imidazoleglycerol phosphate dehydratase: Design of a novel and potent heterocycle structure for the inhibitor on the basis of the electronic structure-activity relationship study

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1385, Issue 1, 1998, Pages 107-114

  Gohda, Keigo ^a   Kimura, Yoko ^a   Mori, Ichiro ^a   Ohta, Daisaku ^a   Kikuchi, Takeshi ^a  

^a CIBA GEIGY LTD   (Switzerland)

Author keywords

Diazafulvene; Enzyme inhibitor; Imidazoleglycerol phosphate dehydratase; Reaction intermediate; Structure activity relationship study

Indexed keywords

1,2,4 THIADIAZOLE DERIVATIVE; 1,2,4 TRIAZOLE DERIVATIVE; HETEROCYCLIC COMPOUND; HISTIDINE; HYDROLYASE; IMIDAZOLEGLYCEROLPHOSPHATE DEHYDRATASE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; ENZYME INHIBITION; ENZYME KINETICS; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

DRUG DESIGN; ENZYME INHIBITORS; HYDRO-LYASES; IMIDAZOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTUM THEORY; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; TRIAZOLES;

EID: 0031839135     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(98)00049-1     Document Type: Article

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