Substituted pyrido[3,2-b]oxazin-3(4H)-ones: Synthesis and evaluation of antinociceptive activity

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 2, 1998, Pages 133-142

  Savelon, L ^a   Bizot Espiard, J G ^b   Caignard, D H ^c   Pfeiffer, B ^c   Renard, P ^c   Viaud, M C ^a   Guillaumet, G ^a  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c ADIR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4[3 [4 (4 FLUOROPHENYL 1 PIPERAZINYL)PROPYL]] 2H PYRIDO[3,2 B] 1,4 OXAZIN 3(4H) ONE; ACETYLSALICYLIC ACID; ANTINOCICEPTIVE AGENT; DYE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE 4 (4 CHLOROPHENYLALANINE)]; KETANSERIN; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; PRAZOSIN; PYRIDO[3,2 B]OXAZIN 3(4H) ONE DERIVATIVE; RAUWOLSCINE; SPIPERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; HIPPOCAMPUS; HOT PLATE TEST; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; REACTION ANALYSIS; WRITHING TEST;

ANALGESICS; ANIMALS; BENZENEACETAMIDES; CIMETIDINE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; GUINEA PIGS; HISTAMINE ANTAGONISTS; MALE; MICE; MODELS, CHEMICAL; NOCICEPTORS; OXAZINES; PYRIDINES; PYRILAMINE; PYRROLIDINES; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031839035     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)10005-0     Document Type: Article

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