Dietary iron elevates LDL-cholesterol and decreases plasma antioxidant levels: Influence of antioxidants

Research Communications in Molecular Pathology and Pharmacology

Volumn 100, Issue 2, 1998, Pages 139-150

  Pool, G F ^a   Van Jaarsveld, H ^a  

^a UNIVERSITY OF THE FREE STATE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; DIETARY INTAKE; IRON METABOLISM; ISCHEMIC HEART DISEASE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RISK FACTOR;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BETA CAROTENE; CHOLESTEROL, HDL; CHOLESTEROL, LDL; IRON, DIETARY; LIPID PEROXIDATION; MALE; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES; VITAMIN A; VITAMIN E;

EID: 0031838844     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Bothwell, T.H. (1995). Overview and mechanism of iron regulation. Nutr. Rev. 53: 237-245.
2. Burt, M.J., Halliday, J.W., Powell, L.W. (1993). Iron and coronary heart disease. Brit.Med.J. 302(6904): 575-576.
3. Burton, G.W., Traber, M.G. (1990). Vitamin E antioxidant activity, biokinetics, and bioavailability. Annu. Rev. Nutr. 10: 357-382.
4. Esterbauer, H., Ramos, P. (1996). Chemistry and pathophysiology of oxidation of LDL. Rev. Physiol. Biochem. Pharmacol. 127: 31-64.
5. Friedewald, W.T., Levy, R.I., Fredrickson, D.S. (1972). Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clin. Chem. 18: 449-502.
6. Fuhrman, B., Judith, O., Keidar, S., Ben-Yaish, L., Kaplan, M., Aviram, M. (1997). Increased uptake of LDL by oxidized macrophages is the result of an initial enhanced LDL receptor activity and of a further progressive oxidation of LDL. Free Rad. Biol. Med. 23: 34-46.
7. Halliwell, B., Chirico, S. (1993). Lipid peroxidation: Its mechanism, meaurement, and significance. Am. J. Clin. Nutr. 57(Suppl 5): 715S-724S.
8. Jiang, Z.Y., Hunt, J.V., Wolff, S.P. (1992). Ferrous iron oxidation in the presence of xylonol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal. Biochem. 202: 384-389.
9. Krinsky, N.I., Deneke, S.M. (1982). Interaction of oxygen and oxy-radicals with carotenoids. J. Nat. Cancer Inst. 69: 205-10.
10. Lauffer, R.B. (1990). Iron stores and the international variation in mortality from coronary artery disease. Med. Hypotheses 35: 96-102.
11. Link, G., Pinson, A., Kahane, I., Hershko, C. (1989). Iron loading modifies the fatty acid composition of cultured rat myocardial cells and liposomal vesicles: effect of ascorbate and α-tocopherol on myocardial lipid peroxidation. J. Lab. Clin. Med. 114: 243-249.
12. Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J. (1951). Protein measurement with Folin phenol reagent. J. Biol. Chem. 193: 265-275.
13. Meyers, D.G., Maloley, P.A. (1993). The antioxidant vitamins: Impact on atherosclerosis. Pharmacotherapy 13: 574-582.
14. Reddy, M.B., Cook, J.D. (1991). Assessment of dietary determinants of nonheme-iron absorption in humans and rats. Am. J. Clin. Nutr. 54: 723-789.
15. Rimm, E.B., Stampfer, M.J., Ascherio, A., Giovannucci, E., Colditz, G.H., Willett, W.C. (1993). Vitamin E consumption and the risk of coronary heart disease in men. N. Eng. J. Med. 328: 1450-1456.
16. Roodenburg, A.J., West, C.E., Hovenier, R., Beynen, A.C. (1995). Evaluation of a two-generation rat model for vitamin A deficiency and the interrelationship with iron metabolism. Br. J. Nutr. 74: 689-700.
17. Rosenfeld, M.E., Tsukada, T., Gown, A.M., Ross, R. (1987). Fatty streak initiation in Watanabe Heritable Hyperlipemic and comparable hypercholesterolemic fat-fed rabbits. Arteriosclerosis 7: 9-23.
18. Salmond, G.W.A., Gellatly, J.B.M. (1970). Some aspects of iron metabolism in rats in relation to toxicity testing, In: Nutrition and disease in experimental animals. Edited by Tavernor, W.D. Crown Copyright (1970). Baillière, Tindall and Cassell, Ltd. London, pp.49-63.
19. Salonen, J.T., Korpela, H., Nyyssönen, K., Porkkala, E., Tuomainen, T.P., Belcher, J.D., Jacobs, D.R., Salonen, R. (1995). Lowering of body iron stores by blood letting and oxidation resistance of serum lipoproteins: A randomized cross-over trial in male smokers. J. Int. Med. 237: 161-168.
20. Staprans, I., Rapp, J.H., Pan, X., Feigold, K.R. (1993). Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats. J. Lipid Res. 37: 420-430.
21. Sullivan, J.L. (1981). Iron and the sex difference in heart disease risk. Lancet 13: 1293-1294.
22. Van Jaarsveld, H., Kuyl, J.M., Wiid, N.M. (1994a). Ischemia/reperfusion injury is aggravated by an iron supplemented diet and is partly prevented by simultaneous antioxidant supplementation. Res. Commun. Mol. Pathol. Pharmacol. 86: 273-285.
23. Van Jaarsveld, H., Kuyl, J.M., Strydom, M.S., Alberts, D.W. (1994b). Chronic cigarette smoke exposure of rats results in significant changes in antioxidants in organs and plasma: effect of antioxidants in myocardial ischemia and reperfusion. Res. Commun. Mol. Pathol. Pharmacol. 86: 273-285.
24. Van Jaarsveld, H., Pool, G.F., Barnard, H.C. (1997a). Influence of ferritin levels on LDL cholesterol concentration in women. Research Communications in Molecular Pathology and Pharmacology 98: 201-208.
25. Van Jaarsveld, H., Pool, G.F., Barnard, H.C. (1997b). Dietary iron concentrations alters LDL-VLDL oxidatively: The effect of antioxidants. Research Communications in Molecular Pathology and Pharmacology 98: 201-208.
26. Wu, T.W., Wu, L.L. (1997). Autoantibodies against oxidized LDL. A potential marker for atherosclerosis. Clin. Lab. Med. 17: 595-604.
27. Young, I.S., Trouton, T.G., Torney, J.J., McMaster, D., Callender, M.E., Trimble, E.R. (1993). Antioxidant status and lipid peroxidation in hereditary haemochromatosis. Free Radical Biol. Med. 16: 393-397.
28. Zilva, J.F., Pannall, P.R. (1979). Purine metabolism. In: Clinical Chemistry, Lloyd-Luke (Medical Books) Ltd, London. pp.378-394.