Anaemia in pregnancy in developing countries

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 105, Issue 4, 1998, Pages 385-390

  Van Den Broek, Nynke ^a  

^a UNIVERSITY OF MALAWI   (Malawi)

Author keywords

[No Author keywords available]

Indexed keywords

ANEMIA; CYANOCOBALAMIN DEFICIENCY; DEVELOPING COUNTRY; FEMALE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HEMOGLOBINOPATHY; HUMAN; INFLAMMATION; IRON DEFICIENCY ANEMIA; NUTRITIONAL DEFICIENCY; PARASITOSIS; PREGNANCY; PREVALENCE; PRIORITY JOURNAL; RETINOL DEFICIENCY; REVIEW;

EID: 0031838224     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.1998.tb10120.x     Document Type: Article

References (115)

1. Letsky EA. The Haematological System. In: Hytten F, Chamberlain G, editors. Clin Physiol Obstet, 1980: 43–78.
2. Letsky EA Blood Volume, Haematinics, Anaemia. In: de Swiet M, editor. Medical Disorders in Obstetric Practice. Oxford : Blackwell Science, 1995: 33–70.
3. World Health Organization. Nutritional anaemias. World Health Organ Tech Rep Ser 1972; 503.
4. Leeuw NKM de, Lowenstein L, Hsieh YS. Iron deficiency anaemia and hydremia in normal pregnancy. Medicine (Baltimore) 1966; 45: 291–315.
5. Johnson-Spear MA, Yip R. Hemoglobin difference between black and white women with comparable iron status: justification for race- specific anaemia criteria. Am J Clin Nutr 1994; 60: 117–121.
6. Baker SJ, DeMaeyer EM. Nutritional anemia: its understanding and control with special reference to the work of the World Health Organization. Am J Clin Nutr 1979; 32: 368–417.
7. Murphy JF, O'Riordan JO, Newcombe RG, Coles EC, Pearson JF. Relation of Haemoglobin levels in first and second trimesters to out-come of pregnancy. Lancet 1986; 1: 992–994.
8. World Health Organization. The prevalence of anaemia in women: a tabulation of available information. Geneva : WHO, 1992.
9. Jackson DJ, Klee EB, Green SDR, Mokili JLK, Elton RA, Cutting WAM. Severe anaemia in pregnancy: a problem of primigravidae in rural Zaire. Trans R Soc Trop Med Hyg 1991; 85: 829–832.
10. World Health Organization. Prevention and management of severe anaemia in pregnancy: report of a technical working group. Geneva : WHO, WHO/FHE/MSM/93.5.
11. Bergsjo P, Seha AM, Ole-King'ori N. Haemoglobin concentration in pregnant women. Experience from Moshi, Tanzania. Acta Obstet Gynecol Scand 1996; 75: 241–244.
12. Fleming AF. The aetiology of severe anaemia in pregnancy in Ndola, Zambia. Ann Trop Med Parasitol 1989; 83: 37–49.
13. World Health Organization. Maternal mortality ratios and rates. Geneva : WHO, WHO/MCH/MSM/91.6.
14. World Health Organization. The prevalence of anaemia in women: a tabulation of available information. Geneva : WHO, WHO/MCH/MSM/92.2.
15. Preventing the Tragedy of Maternal Deaths: a report on the International Safe Motherhood Conference; Nairobi, Kenya; 1987.
16. Harrison KA. Maternal Mortality. Trans R Soc Trop Med Hyg 1989; 83: 449–453.
17. Harrison KA. Severity of anaema and operative mortality and morbidity. Lancet 1988 June 18: 1392.
18. Alauddin M. Maternal mortality in rural Bangladesh: the Tangail District. Stud Fam Plann 1986; 17: 13–21.
19. Viteri FE, Torun B. Anaemia and physical work capacity. In: Garby L, editor. Clinics in Haematology, Vol 3. WB Saunders, 1974: 609–626.
20. Hallberg L, Scrimshaw NS. Iron deficiency and Work Performance. International Nutritional Anemia Consultative Group, 1981.
21. Cook JD, Lynch SR. The liabilities of iron deficiency. Blood 1986; 68: 803–809.
22. Dallman PR. Iron deficiency and the immune response. Am J Clin Nutr 1987; 46: 329–334.
23. Garn SM, Ridella SA, Petzold AS, Falkner F. Maternal hematologic levels and pregnancy outcomes. Semin Perinatol 1981; 5: 155–162.
24. Klebanoff MA, Shiono PH, Selby JV, Trachtenberg AI, Graubard BI. Anemia and spontaneous preterm birth. Am J Obstet Gynecol 1991; 164: 59–63.
25. Allen LH. Iron-Deficiency anemia increases risk of preterm delivery. Nutr Rev 1993; 51; 2: 49–51.
26. Mitchell MC. Lerner E. Maternal hematologic maesures and pregnancy outcome. J Am Diet Assoc 1992; 92: 484–486.
27. Harrison KA, Ibeziako PA. Maternal anaemia and fetal birthweight. J Obstet Gynaecol Br Cmnwlth 1973; 80: 798–804.
28. Steer P, Alam MA, Wadsworth J, Welch A. Relation between maternal haemoglobin concentration and birth weight in different ethnic groups. BMJ 1995; 310: 489–491.
29. Correspondence. Maternal haemoglobin and birth weight in different ethnic groups. BMJ 1995; 310: 1601–1602.
30. Huisman A, Aarnoudse JG. Increased 2nd trimester hemoglobin concentration in pregnancies later complicated by hypertension and growth retardation. Acta Obstet Gynecol Scand 1986; 65: 605–608.
31. Colomer J, Colomer C, Gutierrez D, Jubert A, Nolasco A, Fernandez-Delgrado R et al. Anaemia during pregnancy as a risk factor for infant iron deficiency: report from the Valencia Infant Anaemia Cohort (VIAC) study. Paediatr Perinat Epidemiol 1990; 4: 196–204.
32. Hokama T, Takenaka S, Hirayoma K, Yara A, Yoshida K, Itokazu K et al. Iron status in newborns born to iron deficient anaemic mothers. J Trop Paediatr 1996; 42: 75–77.
33. Prual A, Galan P, Bernis De L, Hereberg S. Evaluation of iron status in Chadian pregnant women: consequences of maternal iron deficiency on the haematopoietic status of newborns. Trop Geogr Med 1988; 40: 1–6.
34. Yepez R, Calle A, Galan P, Estevez E, Davila M, Estrella R et al. Iron status in Ecuadorian pregnant women living at 2,800 m altitude: Relationship with infant iron stores. Int J Vitam Nutr Res 1987; 57: 327–332.
35. Gaspar MJ, Ortega RM, Moreiras O. Relationship between iron status in pregnat women and their newborn babies. Acta Obstet Gynecol Scand 1993; 72; 534–537.
36. Walter T, De Andraca I, Chadud P, Perales CG. Iron deficiency anaemia: Adverse effects on infant psychomotor development. Pediatrics 1989; 84: 7–17.
37. Fleming AF. Anaemia in pregnancy in tropical Africa. Trans R Soc Trop Med Hyg 1989; 83: 441–448.
38. Watson-Williams EJ. Anaemia in the tropics. BMJ 1968; 4: 34–38.
39. Masawe AEJ. Nutritional anaemias: tropical Africa. Clin Haematol 1981: 10: 815–842.
40. Baker SJ. Nutritional anaemias: tropical Asia. Clin Haematol 1981; 10: 843–856.
41. van den Broek NR. The aetiology of anaemia in pregnancy in West Africa. Trop Doct 1996; 26: 5–7.
42. Suhamo D, West CE, Muhilal, Karyadi D, Hautvast GAJ. Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia. Lancet 1993; 342: 1325–1327.
43. World Health Organization. Report of the African Regional Consultation on control of anaemia in pregnancy. Brazzaville, Geneva : WHO, 1989.
44. Mayet FGH. Anaemia of pregnancy. S Afr Med J 1985: 67: 804–809.
45. Svanberg B. Absorption of iron in pregnancy. Acta Obstet Gynecol Scand Suppl 1975; 48: 7–24.
46. Whittaker PG, Lind T, Williams JG. Iron absorption during normal human pregnancy: a study using stable isotopes. Br J Nutr 1991; 65: 457–463.
47. Cardoso MA, Ferreira MU, Camargo LMA, Szarfare SC. Anaemia, iron deficiency and malaria in a rural community in Brazilian Amazon. Eur J Clin Nutr 1994; 48: 326–332.
48. Baynes RD, Skikne BS, Cook JD. Circulating transferrin receptors and assessment of iron status. J Nutr Biochem 1994; 5: 322–330.
49. Carriaga MT, Skikne BS, Finley B, Cutler B, Cook JD. Serum transferrin receptor for the detection of iron deficiency in pregnancy. Am J Clin Nutr 1991; 54: 1077–1081.
50. Murray MJ, Murray CJ, Murray AB, Murray MB. Refeeding malaria and hiperferraenemia. Lancet 1975; 1: 653–654.
51. Murray MJ, Murray AB, Murray MB, Murray CJ. The adverse effect of iron repletion on the course of certain infections. BMJ 1978; 2: 1113–1115.
52. Oppenheimer SJ. Iron and malaria. Parasitol Today 1989; 5: 77–79.
53. Smith AW, Hendrickse RG, Harrison C, Hayes RJ, Greenwood BM. The effects on malaria of treatment with oral iron in Gambian children. Ann Trop Paediatr 1989; 9: 17–23.
54. Chippaux JP, Schneider D, Aplogan A, Dyck JL, Berger J. Effects of iron supplementation on malaria infection. Bull Sac Pathol Exot Filiales 1991; 84: 54–62.
55. Harvey PWJ, Heywood PF, Nesheim MC, Galme K, Zegans M, Habicht JP et al. The effect of iron therapy on malarial infection in Papua New Guinean schoolchildren. Am J Trop Med Hyg 1989; 40: 12–18.
56. Snow RW, Byass P, Shenton FC, Greenwood BM. The relationship between anthropometric measurements and measurements of iron status and susceptibility to malaria in Gambian children. Trans R Soc Trop Med Hyg 1991; 85: 584–589.
57. Fleming AF, Ghatoura GBS, Harrison KS. The prevention of anaemia in pregnancy in primigravidae in the guinea savanna of Nigeria. Ann Trop Med Parasitol 1986; 80: 211–233.
58. Mati JKG, Hatimy A, Gebbie DAM. The importance of anaemia of pregnancy in Nairobi and the role of malaria in the aetiology of megaloblastic anaemia. J Trop Med Hyg 1971; 74: 1–8.
59. Brabin BJ. The role of malaria in nutritional anaemias. In: Fomon SJ, Zlotkin S, editors. Nutritional anemias. 1992: 65–80.
60. Sanfilippo JS, Liu YK. Vitamin B12 deficiency and infertility: report of a case. Int J Fertil 1991; 36: 36–38.
61. Savage D, Gangaidzo, Lindenbaum J, Kiire C, Mukiibi JM, Moyo A et al. Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe. Br J Haematol 1994; 86: 844–850.
62. Baker SJ, Jacob E. Rajan KT, Swaminathan SP. Vitamin B12 deficiency in pregnancy and the puerperium. BMJ 1962, June 6: 1658–1661.
63. VazPinto VA, Santos F, Almeida AM, Cantuaria AA. Trends of folate and vitamin B12 during pregnancy. Rev Invest Clin 1973; 25: 153–158.
64. Cooper BA. Folate and Vitamin B12 in pregnancy. Clin Haematol 1973: 2: 461–476.
65. Savage DG, Lindenbaum J, Stabler SP, Allen RH. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med Sci 1994; 96: 239–246.
66. Green R. Metabolite assays in cobalamin and folate deficiency. Ballieres Clin Haematol 1995; 8: 533–566.
67. World Health Organization. Indicators for assesing vitamin A deficiency and their application in monitoring and evaluating intervention programs. Geneva : WHO, 1994.
68. Hodges RE, Sauberlich HE, Canham JE, Wallace DL, Rucker RB, Meija LA, Mohanram M. Hematopoietic studies in vitamin A deficiency. Am J Clin Nutr 1978; 31: 876–885.
69. Meija LA, Chew F. Hematological effect of supplementing anemic children with Vitamin A alone and in combination with iron. Am J Clin Nutr 1988; 48: 595–600.
70. Bloem MW, Wedel M, van Agtniaal EJ, Speek AJ, Soawakontha S, Schreurs WHP. Vitamin A intervention: short term effects of a single oral massive dose on iron metabolism. Ant J Clin Nutr 1990 51: 76–79.
71. Thuman DI. Vitamin A, iron and haemopoiesis. Lancet 1993; 342: 1312–1313.
72. Fleming AF. Haematologic manifestations of malaria and other parasitic diseases. Clin Haematol 1981; 10: 983–1011.
73. Brabin BJ. An analysis of malaria in pregnancy in Africa. Bull World Health Organ 1983; 61: 1005–1016.
74. McGregor IA. Epidemiology, malaria and pregnancy. Am J Trop Med Hyg 1984; 33: 517–525.
75. Steketee RW, Breman JG, Paluku KM, Moore M, Roy J, Ma-Disu M. Malaria infection in pregnant women in Zaire: the effects and potential for intervention. Ann Trop Med Parasitol 1988; 82: 113–120.
76. Gilles HM, Lawson JB, Sibelas M, Voller A, Allan N. Malaria, anaemia and pregnancy. Ann Trop Med Parasitol 1969; 63: 245–263.
77. Shulman CE, Graham WJ, Jilo H, Lowe BS, New L, Obiero J et al. Malaria is an important cause of anaemia in primigravidae: evidence from a district hospital in coastal Kenya. Trans R soc Trop Med Hyg 1996; 90: 535–539.
78. Draper CC. Effect of malaria control on haemoglobin levels. BMJ 1960, May 14: 1480–1483.
79. Scofield FD, Parkinson AD, Kelly A. Changes in haemoglobin values and hepatosplenomegaly produced by control of holoendemic malaria. BMJ 1964; 7 March: 587–591.
80. Annual Report of Indian Council of Medical Research. Hyderabad, India : National Institute of Nutrition, 1974: 148.
81. Kortmann HFC. Malaria and pregnancy [MD thesis]. University of Amsterdam, Utrecht; Drukkerij Elinkwijk; 1972.
82. Rougemont A, Dumbo O, Bouvier M, Soula G, Perrin L, Tamoura B et al. Hypohaptoglobinaemia as an epidemiological and clinical indicator for malaria. Lancet 1988, Sept 24: 709–712.
83. McGuire W, Alessandro U, Olaleye BO, Thomson MC, Langerock P, Greenwood BM et al. C-reactive protein and haptoglobin in the evaluation of a community based malaria control program. Trans R Soc Trop Med Hyg 1996; 90: 10–14.
84. Gilles HM, WatsonWilliams EJ, Ball PAJ. Hookworm infection and anaemia. Q J Med 1964; 129: 1–23.
85. Crompton DWT, Whitehead RR. Hookworm infections and human iron metabolism. Parasitology 1993; 107: S137–S145.
86. Miller TA. Hookworm infection in man. Adv Parasitol 1979; 17: 315–385.
87. Willoughby MLN. Haematological disorders: anaemia. Clin Obstet Gynecol 1977; 4: 371–395.
88. Yip R, Dallman PR. The roles of inflammation and iron deficiency as causese of anaemia. Am J Clin Nutr 1988; 48: 1295–1300.
89. Rosenthal DS. Hematologic manifestations of infectious disease. In: Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, editors. Hematology: Basic Principles and Practice. Edinburgh : Churchill Livingstone.
90. van den Broek NR, White SA, Neilson JP. The relationship between asymptomatic HIV infection and the incidence and seventy of anaemia in pregnant Malawian women. Submitted.
91. Costello C. The haematological manifestations of HIV disease. In: Hornrand V, Tuddenham EGD, Lewis SM, editors. Postgraduate Haematology. Oxford : Butterworth-Heinemann, 1997.
92. Hoxie JA. Hematologic manifestations of AIDS. In: Hoffman R et al., editors. Hematology: Basic Principles and Practice. Edinburgh : Churchill Livingstone, 1995: 2171–2200.
93. Zon LI, Arkin C, Groopman JE. Haematologic manifestations of human immune deficiency virus (HIV). Br J Haematol 1987; 66: 251–256.
94. Zon LI, Groopman JE. Hematologic manifestations of the human immune deficiency virus (HIV). Semin Haematol 1988; 25: 208–218.
95. Davis BR, Zauli G. Effect of human immunodeficiency virus infection on haematopoiesis. Baillieres Clin Haematol 1995; 8: 113–130.
96. Scadden DT, Zon LI, Groopman JE. Pathofysiology and management of HIV associated haematologic disorders. Blood 1989; 74: 1455–1463.
97. Mir N, Costello C, Luckit J, Lindley R. HIV-disease and bone marrow changes: a study of 60 cases. Eur J Haematol 1989; 42: 339–343.
98. Richman DD, Fischl MA, Grieco MH et al. AZT Collaborative Working Group: the toxicity of azidothymidine (AZT) in the treatment of patients with AIDS, AIDS-related complex: a double blind, placebo controlled trial. N Engl J Med 1987; 317: 192–197.
99. Street AM, Milliken ST. HIV-related haematological disease. Med J Aust 1993; 158: 172–174.
100. Abrams DI. Lymphadenopathy related to the acquired immunodeficiency syndrome in homosexual men. Med Clin N Am 1986; 70: 693.
101. Metroka CE, Cunningham-Rundles S, Pollack MS. Generalised lymphadenopathy in homosexual men. Ann Intern Med 1983; 99: 585.
102. Bobat RA, Coovadia HM, Windsor IM. Some early observations on HIV infection in children at King Edward VIII Hospital, Durban. S Afr Med J 1990; 78: 524–527.
103. Adewuyi J, Chitsike I. Haematologic features of the human immunodeficiency virus in Black children in Harare. Centr Afr J Med 1994; 40: 333–336.
104. Rust OA, Peny KG. Pregnancy complicated by sickle haemoglobinopathy. Clin Obstet Gynecol 1995; 38; 472–484.
105. El Shafei AM, Dhaliwal KJ, Saudhu KA, Al-Shaqi RM. Indications for blood transfusion in pregnancy with sickle cell disease. Aust N Z J obstet Gynaecol 1995: 35: 405–408.
106. Koshy M. Sickle cell disease and pregnancy. Blood Rev 1995; 9: 157–164.
107. Peny KG, Morrison JC. Hematologic disorders in pregnancy. Obstet Gynecol Clin North Am 1992; 19: 783–799.
108. Pastorek JG, Saseiler B. Maternal death associated with sickle cell trait. Am J Obstet Gynecol 1985; 151: 295–297.
109. Williams TN, Maitland K, Ganczakowski M, Peto TEA, Clegg JB, Weatherall DJ, Bowden DK. Red blood cell phenotypes in the alpha + thalassaemias from early childhood to maturity. Br J Haematol 1996; 95: 266–272.
110. Bowden DK, Hill AVS, Higgs DR, Weatherall DJ, Clegg JB. Relative roles of genetic factors, dietary deficiency and infection in anaemia in Vanuatu, South-West Pacific. Lancet 1985; 9 Nov: 1025–1028.
111. Beutler E. G6PD deficiency. Blood 1994; 84: 3613–3636.
112. Bates I, Bedu-Addo G, Rutherford T, Bevan DH. Splenic lymphoma with villous lymphocytes in tropical West Africa. Lancet 1992; 340: 575–577.
113. Bates I. Hyperreactive malarial splenomegaly in pregnancy. Trop Doct 1991; 21: 101–103.
114. Marsden D, Hutt MSR, Wilks NE, Voller A, Blackman V, Shah KK et al. An investigation of Tropical Splenomegaly at Mulago Hospital, Kampala, Uganda. BMJ 1965; 9 Jan: 89–92.
115. Hamilton PJS, Gebbie DAM, Hutt MSR, Lothe F, Wilks NE. Anaemia in pregnancy associated with ‘big spleen disease’. BMJ 1966; 3 Sep: 584–587.