Mechanisms of synergism between Gemcitabine and cisplatin

Advances in Experimental Medicine and Biology

Volumn 431, Issue , 1998, Pages 581-585

  Van Moorsel, C J A ^a   Veerman, G ^a   Vermorken, J B ^a   Voorn, D A ^a   Kroep, J R ^a   Bergman, A M ^a   Pinedo, H M ^a   Peters, G J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; GEMCITABINE;

CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG POTENTIATION; HUMAN; HUMAN CELL; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL;

EID: 0031836756     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5381-6_112     Document Type: Conference Paper

References (11)

1. Van Moorsel CJA, Peters GJ and Pinedo HM: Gemcitabine: future prospects of single agent and combination studies. The Oncologist 2:127-134, 1997.
2. Terheggen PMAB, Emondt JY, Floot BGJ, Dijkman R, Schrier PI, Den Engelse L and Begg AC: Correlation between cell killing by cis-diamminedichloroplatinum(II) in six mammalian cell lines and binding of a cis-diamminedichloroplatinum(II)-DNA antiserum. Cancer Res 50:3556-3561, 1990.
3. Parker RJ, Gill I, Tarone R, Vionnet J, Grunberg S, Muggia F and Reed E: Platinum DNA-damage in leukocyte DNA of patients receiving cisplatin and carboplatin chemotherapy, measured by atomic absorption spectrometry. Carcinogenesis 12:1253-1258, 1991.
4. Peters GJ, Bergman AM, Ruiz van Haperen VWT, Veerman G, Kuiper CM and Braakhuis BJM: Interaction between gemcitabine and cisplatin in vitro and in vivo. Semin Oncol 22(suppl 11):72-79, 1995.
5. Bergman AM, Ruiz van Haperen VWT, Veerman G, Kuiper CM and Peters GJ: Synergistic interaction between cisplatin and gemcitabine in vitro. Clin Cancer Res 2:521-530, 1996.
6. th NCIEORTC Ann Oncol 7(suppl 1):65 [abstract 219], 1997.
7. Braakhuis BJM, Ruiz van Haperen VWT, Welters MJP and Peters GJ: Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts. Eur J Cancer 31A:2335-2340, 1995.
8. Van Moorsel CJA, Veerman G, Bergman AM, Guechev A, Vermorken JB, Postmus PE and Peters GJ: Combination chemotherapy studies with gemcitabine. Semin Oncol, in press.
9. Langeveld CH, Jongenelen CAM., Theeuwes JWM, Baak JPA, Heimans JJ, Stoof JC and Peters GJ: The antiproliferative effect of 8-chloro-adenosine, and active metabolite of 8-chloro-cyclic adenosine monophosphate, and disturbances in nucleic acid synthesis and cell cycle kinetics. Biochem Pharmacol 53:141-148, 1997.
10. Ruiz van Haperen VWT, Veerman G, Vermorken JB, Pinedo HM and Peters GJ:. Regulation of deoxycytidine kinase from solid tumor cell lines by CTP and DTP. Biochem Pharmacol 51:911-918, 1996.
11. Chiu CSM, Chan, AK, and Wright, JA: Inhibition of mammalian ribonucleotide reductase by cis-diamminedichloroplatinum(II). Biochem. Cell Biol 70:1332-1338, 1992.