Insights into adenosine deaminase deficiency provided by murine fetal thymic organ culture with 2′-deoxycoformycin

Advances in Experimental Medicine and Biology

Volumn 431, Issue , 1998, Pages 451-454

  Resta, Regina ^a   Jiang, Hong ^a   Hooker, Scott W ^a   Laurent, Aletha B ^a   Thompson, Linda F ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; ADENOSINE TRIPHOSPHATE; CD4 ANTIGEN; CD8 ANTIGEN; DEOXYADENOSINE; DEOXYADENOSINE TRIPHOSPHATE; HYDROXYUREA; PENTOSTATIN; RIBONUCLEOTIDE REDUCTASE;

ANIMAL CELL; ANIMAL TISSUE; CELL MATURATION; CONFERENCE PAPER; ENZYME DEFICIENCY; FETUS; MOUSE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS;

ADENOSINE DEAMINASE; ANIMALS; ENZYME INHIBITORS; FETUS; HYDROXYUREA; IMMUNOPHENOTYPING; MICE; MICE, INBRED C57BL; ORGAN CULTURE TECHNIQUES; PENTOSTATIN; RIBONUCLEOTIDE REDUCTASES; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THYMUS GLAND;

ANIMALIA; MURINAE;

EID: 0031836420     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5381-6_89     Document Type: Article

References (9)

1. Hershfield, M.S. and B. S. Mitchell. 1995. Immunodeficiency diseases caused by adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. In The metabolic and molecular basis of inherited disease. Seventh ed. C.R. Scriver, A.L. Beaudet, W.S. Sly and D. Valle, eds. McGraw-Hill, Inc. New York, p. 1725.
2. Blaese, R. M., K. W. Culver, A. D. Miller, C. S. Carter, T. Fleisher, M. Clerici, G. Shearer, L. Chang, Y. Chiang, P. Tolstoshev, J. J. Greenblatt, S. A. Rosenberg, H. Klein, M. Berger, C. A. Mullen, W. J. Ramsey, L. Muul, R. A. Morgan, and W. F. Anderson. 1995. T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years. Science 270:475.
3. Bordignon, C., L. D. Notarangelo, N. Nobili, G. Ferrari, G. Casorati, P. Panina, E. Mazzolari, D. Maggioni, C. Rossi, P. Servida, A. G. Ugazio, and F. Mavilio. 1995. Gene therapy in peripheral blood lymphocytes and bone marrow for ADA- immunodeficient patients. Science 270:470.
4. Migchielsen, A. A. J., M. L. Breuer, M. A. van Roon, H. te Riele, C. Zurcher, F. Ossendorp, S. Toutain, M. S. Hershfield, A. Berns, and D. Valerio. 1995. Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. Nature Genet. 10:279.
5. Wakamiya, M., M. R. Blackburn, R. Jurecic, M. J. McArthur, R. S. Geske, J. J. Cartwright, K. Mitani, S. Vaishnav, J. W. Belmont, R. E. Kellems, M. J. Finegold, C. A. J. Montgomery, A. Bradley, and C. T. Caskey. 1995. Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice. Proc. Natl. Acad. Sci. USA 92:3673.
6. Jenkinson, E. J. and J. J. T. Owen. 1990. T cell differentiation in thymus organ cultures. Semin. Immunol. 2:51.
7. Fox, R. I., L. F. Thompson, and J. R. Huddlestone. 1981. T cells express T-lymphocyte associated antigens. J. Immunol. 126:2062.
8. Lalli, E., P. Sassone-Corsi, and R. Ceredig. 1996. Block of T lymphocyte differentiation by activation of the cAMP-dependent signal transduction pathway. EMBO J. 15:528.
9. Ullman, B., A. Cohen, and D. W. Martin, Jr. 1976. Characterization of a cell culture model for the study of adenosine deaminase- and purine nucleoside phosphorylase-deficient immunologic disease. Cell 9:205.