A systematic review of single-dose intramuscular methotrexate for the treatment of ectopic pregnancy

Australian and New Zealand Journal of Obstetrics and Gynaecology

Volumn 38, Issue 2, 1998, Pages 145-150

  Parker, Jim ^a,c   Bisits, Andrew ^b   Proietto, Anthony M ^a  

^a JOHN HUNTER HOSPITAL   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c LIVERPOOL HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE;

ACUTE ABDOMEN; ADULT; ALOPECIA; ANEMIA; ARTICLE; CLINICAL TRIAL; ECTOPIC PREGNANCY; FEMALE; HEMOPERITONEUM; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; LAPAROTOMY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; META ANALYSIS; NEUTROPENIA; PNEUMONIA; PRIORITY JOURNAL;

EID: 0031836314     PISSN: 00048666     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1479-828X.1998.tb02988.x     Document Type: Article

References (32)

1. Parker JL, Bisits A. Laparoscopic surgical treatment of ectopic pregnancy: Salpingectomy or salpingostomy? Aust NZJ Obstet Gynaecol 1997; 37. 115-117.
2. Chu E, Drake JC, Boarman D, Baram J, Allegra CJ. Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells. J Biol Chem 1990, 265. 8470-8478.
3. Floridon C, Thomsen SG. Methotrexate treatment of ectopic pregnancy. Acta Obstet Gynecol Scand 1994; 73: 746-752.
4. Li MC, Hertz R, Spencer DB. Effects of methotrexate therapy on choriocarcinoma and chorioadenoma. Proc Soc Biol Med 1956; 93: 361-367.
5. Lathrop JC, Bowles GE Methotrexate in abdominal pregnancy: Report of a case. Obstet Gynecol 1968; 32: 81-85.
6. Tanaka T, Hayashi H, Kutsuzawa T, Fujimoto S, Ichinoe K. Treatment of interstitial ectopic pregnancy with methotrexate: Report of a successful case. Fertil Steril 1982; 37: 851-852.
7. Stovall TG, Ling FW, Buster JE. Outpatient chemotherapy of unruptured ectopic pregnancy. Fertil Steril 1989; 51: 435-438.
8. Stovall TG, Ling FW, Gray LA. Single-dose methotrexate for treatment of ectopic pregnancy. Obstet Gynecol 1991; 77: 754-757.
9. Isaacs JD, McGehee RP, Cowan BD. Life-threatening neutropenia following methotrexate treatment of ectopic pregnancy: A report of two cases. Obstet Gynecol 1996; 88: 694-696.
10. Frishman GN, Seifer DB. Hematosalpinx after methotrexate treatment of unruptured ectopic pregnancy. Fertil Steril 1993; 60: 571-572.
11. Abbott J, Abbott R. Ruptured ectopic pregnancy after medical management: Current conservative management strategies. Am J Emerg Med 1993; 11: 480-482.
12. Trout S, Kemmann E. Reversible alopecia after single-dose methotrexate treatment in a patient with ectopic pregnancy. Fertil Steril 1995; 64: 866-867.
13. Zullo F, Pellicano M, Carlo C, De Stefano R, Mastrantonio P, Nappi C. Late complications after systemic methotrexate treatment of unruptured ectopic pregnancies: a report of three cases. Eur J Obstet Gynecol Reprod Biol 1996; 70: 213-214.
14. Horrigan TJ, Fanning J, Marcotte MP. Methotrexate pneumonitis after systemic treatment for ectopic pregnancy. Am J Obstet Gynecol 1997; 176: 714-715.
15. Heininen S, Penttinen J, Ryynanen M. Severe intraperitoneal haemorrhage in ectopic pregnancy. Int J Gynecol Obstet 1996; 52: 189-190.
16. Kim PY, de La Vallee C. Isthmic gestation: a contraindication to methotrexate therapy? Am J Obstet Gynecol 1997; 176: 711-712.
17. Dunn RC, Taskm O. Chronic ectopic pregnancy after clinically successful methotrexate treatment of ectopic pregnancy. Int J Gynecol Obstet 1995; 51: 247-249.
18. Schoenfeld A, Mashiach R, Vardy M, Ovadia J. Methotrexate pneumonitis in nonsurgical treatment of ectopic pregnancy. Obstet Gynecol 1992; 80: 520-521.
19. Dunn RC, Taskin O. Chronic ectopic pregnancy after clinically successful methotrexate treatment of ectopic pregnancy. Int J Obstet Gynecol 1995; 51: 247-249.
20. Stika CS, Anderson L. Frederiksen MC. Single-dose methotrexate for the treatment of ectopic pregnancy: Northwestern Memorial Hospital three-year experience. Am J Obstet Gynecol 1996; 174: 1840-1848.
21. Glock JL, Johnson JV, Brumsted JR. Efficacy and safety of single-dose systemic methotrexate in the treatment of ectopic pregnancy. Fertil Steril 1994; 62: 716-721.
22. Stovall TG, Ling FW. Single-dose methotrexate: An expanded clinical trial. Am J Obstet Gynecol 1993; 168: 1759-1765.
23. Henry MA, Gentry WL. Single injection of methotrexate for treatment of ectopic pregnancies. Am J Obstet Gynecol 1994; 171: 1584-1587.
24. Gross Z, Rodriguez JJ, Stalnaker BL. Ectopic pregnancy: Nonsurgical, outpatient evaluation and single-dose methotrexate treatment. J Reprod Med 1995; 40: 371-374.
25. Corsan GH, Karacan M, Qasim S, Bohrer MK, Ransom MX, Kemmann E. Identification of hormonal parameters for successful systemic single-dose methotrexate therapy in ectopic pregnancy. Hum Reprod 1995; 10: 2719-2722.
26. Ransom MX, Garcia AJ, Bohrer M, Corsan GH, Kemmann E. Serum progesterone as a predictor of methotrexate success in the treatment of ectopic pregnancy. Obstet Gynecol 1994; 83: 1033-1037.
27. Hidlebaugh D, O'Mara P. Clinical and financial analyses of ectopic pregnancy management at a large health plan. J Am Assoc Gynecol Laparosc 1997; 4: 207-213.
28. Thoen LD, Creinin MD. Medical treatment of ectopic pregnancy with methotrexate. Fertil Steril 1997; 68: 727-730.
29. Wolf GC, Nickisch SA, George KE, Teicher JR, Simms TD. Completely nonsurgical management of ectopic pregnancies. Gynecol Obstet Invest 1994; 37: 232-235.
30. McCord ML, Muram D, Lipscomb GH, Powell MP, Arheart KL. Methotrexate therapy for ectopic pregnancy in adolescents. J Paediatr Adolesc Gynecol 1996; 9: 71-73.
31. Lui A, D'Ottavio G, Rustico MA et al. Conservative management of ectopic pregnancy. Minerva Ginecol 1997; 49: 67-72.
32. Petitti DB ed. In: Meta-Analysis, decision analysis and cost-effectiveness analysis. Methods for quantitative synthesis in medicine. New York, Oxford University Press, 1994.