In-vitro and in-vivo evaluation of commercial and microencapsulated sustained release tablets containing diclofenac sodium

Saudi Pharmaceutical Journal

Volumn 6, Issue 1, 1998, Pages 65-70

  Hosny, Ehab A ^a   Al Helw, Abd Al Raheem M ^a   Niazy, Esmail M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Diclofenac sodium; Evaluation; In vitro; In vivo; Microcapsules; Sustained release tablets

Indexed keywords

DICLOFENAC; ETHYL CELLULOSE; EUDRAGIT RS;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; MALE; MICROCAPSULE; MICROENCAPSULATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PHASE SEPARATION; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; TABLET COMPRESSION; TABLET FORMULATION;

EID: 0031835889     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Bakan JA, Andersen JL Microencapsulation In "The Theory and Practice of Industrial Pharmacy", 2nd ed., Lea and Febiger, Philadelphia, P.A.
2. Donbrow M, Samuelov Y. Zero-order drug delivery from double-layered porous films: release rate profiles from ethylcellulose, hydroxypropylcellulose and polyethylene glycol mixtures. J. Pharm. Pharmacol. 1980; 32:463-70.
3. Benita S, Donbrow M. Release kinetics of sparingly soluble drugs from ethylcellulose-walled microcapsules:theopylline microcapsules. J. Pharm. Pharmacol. 1982; 34:77-82.
4. Nixon JR, Agyilirah GA. Effect of microcapsules-wall ratio and aggregate size on the properties of tableted microcapsules. J. Pharm. Sci. 1984; 73:52-54.
5. Goto S, Uchida T, Aoyama, T. Preparation and biopharmaceutical evaluation of microcapsules of ampicillin. J. Pharmacobiodyn. 1985; 8:270-77.
6. Lin SY, Yang JC. Bioavailability studies of theophylline ethylcellulose microcapsules prepared by using ethylene-vinyl acetate copolymer as a coacervation-inducing agent. J. Pharm. Sci. 1987; 76:219-23.
7. Ruiz R, Sakr A, Sprockel OL. A study on the manufacture and in-vitro dissolution of terbutalin sulphate microcapsules and their tablets. Drug Dev. Ind. Pharm. 1990; 16:1829-42.
8. Hassan M, Najib N, Suleiman M, El-Sayed Y, Abdel-Hamid M. In-vitro and in-vivo evaluation of sustained release and enteric coated microcapsules of diclofenac sodium. Drug Dev. Ind. Pharm. 1992; 18:1981-88.
9. Benita S, Hoffman A, Donbrow M. Microencapsulation of paracetamol using polyacrylate resins (Eudragit retard), Kinetics of drug release and evaluation of kinetic method. J. Pharm. Pharmacol. 1985; 37:391-95.
10. Kawata M, Nakamura M, Goto S, Aoyama T. Preparation and dissolution pattern of Eudragit RS microcapsules containing ketoprofen. Chem. Pharm. Bull. 1986; 34:2618-23.
11. Meshali MM, El-Helw AE., El-Fattah EA. A study of different systems for the preparation of microcapsules of water soluble drug using Eudragit RS as a wall forming material. Acta Pharm. Fennica. 1992; 101:127-34.
12. Meshali MM, El-Helw AE, El-Fattah EA. In-vitro and in-vivo study of phenobarbitone sodium microcapsules with Eudragit RS. Acta Pharm. Fennica. 1992; 101:135-40.
13. Shan Y. Effect of excipients on tablet properties and dissolution behavior of theophylline-tableted microcapsles under different compression forces. J. Pharm. Sci. 1988; 77:229-32.
14. Jalsenjak I, Nixon JR, Senjkovic R, Stivic I. Sustained-release dosage forms of microencapsulated isoniazide. J. Pharm. Pharmacol. 1980; 32:678-80.
15. Jalsenjak I, Constantia F, Nixon J. Dissolution from tablets prepared using ethylcellulose microcapsules. J. Pharm. Pharmacol. 1977; 29:169-72.
16. Nixon JR, Hassan M. The effect of tableting on the dissolution behavior of thiabendazole microcapsules. J. Pharm. Pharmacol. 1980; 32:857-59.
17. Joseph R, George AA. Effect of microcapsule core-wall ratio and aggregate size on the properties of tableted microcapsules. J. Pharm. Sci. 1984; 73:52-54.
18. Akubuga J. Some factors affecting properties and dissolution behavior of tableted furosemide microspheres. Pharmazie. 1992; 47:128-31.
19. Walker SE, Ganley J, Eaves T. Tableting properties of potassium chloride microcapsules; in F.I.P. Abstracts, 37th International Congress of Pharmaceutical Sciences. The Hague, 1977; p.31.
20. Giunchedi P, Torre ML, Magg L, Conti U. Cellulose acetate trimellitate microspheres containing NSAIDs. Drug Dev. Ind. Pharm. 1995; 21:315-30.
21. Betageri GV, Kurumaddali KR, Ravis WR. Preparation and in vitro evaluation of mefenamic acid sustained release beads. Drug Dev. Ind. Pharm. 1995; 21:265-75.
22. Narong S, Pilawan M. Effect of compression force and type of fillers on release of diclofenac sodium from matrix tablets. Drug Dev. Ind. Pharm. 1994; 20:1049-61.
23. Nishihata T. Simple formulation of sustained-release tablets of sodium diclofenac and examination in humans Int. J. Pharm. 1987; 40:125-28.
24. El-Sayed YM, Abdel-Hamid ME, Suleiman MS, Najib NM. A rapid and sensitive high-performance liquid Chromato-graphic method for the determination of diclofenac sodium in serum and its use in pharmacokinetic studies. J. Pharm. Pharmacol. 1988; 40:727-29
25. Nixon JR, Harris MS. Flow Characteristics of microcapsules I: Flow of ethylcellulose microcapsules through static orifices. Acta Pharm. Tech. 1983; 29:41-45.