Synthesis and inhibitory activity of novel tri- and tetracyclic quinolines against topoisomerases

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 6, 1998, Pages 735-742

  Sui, Zhihua ^a   Altom, Jason ^a   Nguyen, Van N ^a,b   Fernandez, Jeff ^a   Bernstein, Jeff I ^a   Hiliard, Jamese J ^a   Barrett, John F ^a,b   Podlogar, Brent L ^a   Ohemeng, Kwasi A ^a,b  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

DNA gyrase; Isoindolo 2,1 a quinolines; Pyrrolo 1,2 a quinolines; Topoisomerase II

Indexed keywords

DNA TOPOISOMERASE INHIBITOR; GYRASE INHIBITOR; QUINOLINE DERIVATIVE;

ARTICLE; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN;

BACTERIA; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; HUMANS; INDOLES; PYRROLES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031835366     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00030-3     Document Type: Article

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