Kinetic modeling for macromolecule loading into crosslinked polyacrylamide hydrogel matrix by swelling

Pharmaceutical Development and Technology

Volumn 3, Issue 2, 1998, Pages 241-249

  Chen, Li Lan H ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Insulin loading; Polyacrylamide hydrogel; Rate of input and output; Swelling kinetic model

Indexed keywords

HYDROCHLORIC ACID; PIG INSULIN; POLYACRYLAMIDE;

ARTICLE; HYDROGEL; INSULIN RELEASE; IONIC STRENGTH; KINETICS; MACROMOLECULE; MODEL; PRIORITY JOURNAL;

EID: 0031834960     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.3109/10837459809028501     Document Type: Article

References (19)

1. N. A. Peppas and A. R. Khare, Preparation, structure and diffusional behavior of hydrogels in controlled release, Adv. Drug Del. Rev., 11, 1-35 (1993).
2. P. J. Flory, Principles of Polymer Chemistry, Cornell University Press, Ithaca, NY, 1953, pp. 576-590.
3. V. Kudela, Hydrogels, in Encyclopedia of Polymer Science and Technology, Vol. 7 (H. F. Mark and J. I. Kroschwitz, eds.), Wiley, New York, 1985, pp. 783-807.
4. A. Katchalsky, S. Lifson, and H. Eisenberg, Equation of swelling for polyelectrolyte gels, J. Poly. Sci., 7, 571-574 (1951).
5. R. A. Siegel and B. A. Firestone, pH-dependent equilibrium swelling properties of hydrophobic polyelectrolyte copolymer, Macromolecules, 21, 3254-3259 (1988).
6. A. S. Hoffman, Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics, J. Controled Release, 6, 297-305 91988).
7. T. Tanaka, Gels, in Encyclopedia of Polymer Science and Technology, Vol. 7 (H. F. Mark and J. I. Kroschwitz, eds.), Wiley, New York, pp. 514-531 (1985).
8. M. Irie, Photoresponsive polymers, Adv. Polym. Sci., 94, 28-67 (1990).
9. J. Bonaventura, S. Robert, and D. Millington, Acrylamide in polyacrylamide gel can modify proteins during electrophoresis, Anal. Biochem., 222, 44-48 (1994).
10. M. Chiari, P. G. Righetti, A. Negri, F. Ceciliani, and S. Ronchi, Preincubation with cystein prevents modification of sulfhydroxyl groups in proteins by unreacted acrylamide in a gel, Electrophoresis, 13(11), 882-884 (1992).
11. O. G. Berg, Effective diffusion rate through a polymer network: influence of nonspecific binding and intersegment transfer, Biopolymer, 25(5), 811-821 (1986).
12. D. E. Taylor and J. E. Penhallow, Comparative biotolerance of polyacrylamide-agarose gel, silicone rubber and microporous PTFE as soft tissue implants, Biomaterials, 7(4), 277-282 91986).
13. L. K. Huang, R. C. Mehta, and P. P. DeLuca, Development of a statistical model for the formation of poly(acryloyl hydroxyethyl starch) microspheres, Pharm. Res., 14(4), 469-474 (1997).
14. L. K. Huang, R. C. Mehta, and P. P. DeLuca, Evaluation of a statistical model for the formation of poly[acryloyl hydroxyethyl starch] microspheres, Pharm. Res., 14(4), 475-482 (1997).
15. S. W. Kim, Y. H. Bae, and T. Okano, Hydrogel: selling, drug loading and release, Pharm. Res., 9(3), 283-290 (1992).
16. A. J. Banga, Transdermal Iontophoretic Delivery of Peptide Drugs: Delivery Mechanisms and Hydrogel Formulations, Ph.D. Thesis, Rutgers, New Brunswick, NJ, 1990.
17. E. M. Jordan and S. Raymond, Gel electrophoresis: a new catalyst for acid systems, Anal. Biochem., 27, 205-211 (1969).
18. A. Pepters, and S. J. Candau, Kinetics of swelling of polyacrylamide gels, Macromolecules, 19, 1952-1955 (1986).
19. S. H. Gehrke, Mass transfer in pH-sensitive hydrogels, Chem. Eng. Sci., 44(3), 559-566 (1989).