Ectopic expression of the CRF-binding protein: Minor impact on HPA axis regulation but induction of sexually dimorphic weight gain

Journal of Neuroendocrinology

Volumn 10, Issue 7, 1998, Pages 483-491

  Lovejoy, D A ^a,b   Aubry, J M ^a   Turnbull, A ^a   Sutton, S ^a   Potter, E ^a   Yehling, J ^a   Rivier, C ^a   Vale, W W ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Binding protein; CRF; Glucocorticoids; HPA regulation; LPS; Urocortin

Indexed keywords

COMPLEMENTARY DNA; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; HUMAN GROWTH HORMONE; LIPOPOLYSACCHARIDE;

ARTICLE; GENE SEQUENCE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; KIDNEY; LIVER; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; TRANSGENE; TRANSGENIC MOUSE;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ANIMALS; CARRIER PROTEINS; CORTICOSTERONE; FEMALE; GENE EXPRESSION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, TRANSGENIC; ORGAN SPECIFICITY; POLYMERASE CHAIN REACTION; RNA-DIRECTED DNA POLYMERASE; SEX CHARACTERISTICS; WEIGHT GAIN;

EID: 0031834639     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.1998.00206.x     Document Type: Article

References (65)

1. Arase K, York DA, Shimizu H, Shargil NS, Bray GA. Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats. Am J Physiol 1988; 255: E255-E259.
2. Glowa J, Gold P. Corticotropin-releasing hormone produces profound anorexic effects in the rhesus monkey. Neuropeptides 1991; 18: 55-61.
3. Sutton RE, Koob GF, LeMoal M, Rivier J, Vale W. Corticotropin-releasing factor produces behavioural activation in rats. Nature 1982; 297: 333-335.
4. Diamant M, De Weid D. Autonomic and behavioural effects of centrally administered corticotropin-releasing factor in rats. Endocrinology 1991; 129: 446-454.
5. Lenz HJ, Fisher LA, Vale WW, Brown MR. Corticotropin-releasing factor, sauvagine, and urotensin-I: effects on blood flow. Am J Physiol 1985; 249: E85-E90.
6. Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull A, Lovejoy D, Rivier C, Rivier J, Sawchenko PE, Vale W. Urocortin, a mammalian neuropeptide related to fish urotensin-I and to corticotropin-releasing factor. Nature 1995; 378: 287-292.
7. Donaldson CJ, Sutton SW, Perrin MP, Corrigan AZ, Lewis KA, Rivier JE, Vaughan JM, Vale WW. Cloning and characterization of human urocortin. Endocrinology 1996; 137: 2167-2170.
8. Chen R, Lewis KA, Perrin MH, Vale WW. Expression cloning of a human corticotropin-releasing factor receptor. Proc Natl Acad Sci USA 1993; 90: 8967-8971.
9. Chang C-P, Pearse RV, O'Connell S, Rosenfeld MG. Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Neuron 1993; 11: 1187-1195.
10. Kishimoto T, Pearse RV, Lin CR, Rosenfeld MG. A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc Natl Acad Sci USA 1995; 92: 1108-1112.
11. Lovenberg TW, Liaw CW, Grigoriadis DE, Clevenger W, Chalmers DT, De Souza EB, Oltersdorf T. Cloning and characterization of a functionally distinct-releasing factor receptor subtype from rat brain. Proc Natl Acad Sci USA 1995; 92: 836-840.
12. Perrin MH, Donaldson CJ, Chen R, Lewis KA, Vale WW. Cloning and functional expression of a rat brain corticotropin-releasing factor (CRF) receptor. Endocrinology 1993; 133: 3058-3061.
13. Stenzel P, Kesterson R, Yeung W, Cone RD, Rittenberg MB, Stenzel-Poore MP. Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart. Mol Endocrinol 1995; 9: 637-645.
14. Spina M, Merlo-Pich E, Chan RKW, Basso AM, Rivier J, Vale W, Koob G. Appetite-suppressing effects of urocortin, a CRF-related peptide. Science 1996; 273: 1561-1564.
15. Wong M-I, Al-Shekhlee A, Bongiorno PB, Esposito A, Khatri P, Sternberg ES, Gold PW, Licino J. Localization of urocortin gene transcription in rat brain and pituitary. Mol Psychiat 1996; 1: 307-312.
16. Orth DN, Mount CD. Specific high affinity binding protein for human corticotropin-releasing hormone in normal human plasma. Biochem Biophys Res Comm 1987; 143: 411-417.
17. Linton EA, Wolfe CDA, Behan DP, Lowry PJ. A specific carrier substance for human CRF in late gestational maternal plasma which could mask the ACTH-releasing activity. Clin Endocrinol 1988; 28: 315-324.
18. Behan DP, Linton EA, Lowry PJ. Isolation of the human plasma corticotropin-releasing factor-binding protein. J Endocrinol 1989; 122: 23-31.
19. Potter E, Behan DP, Fischer WH, Linton EA, Lowry PJ, Vale WW. Cloning and characterization of the cDNAs for human and rat corticotropin-releasing factor-binding proteins. Nature 1991; 349: 423-426.
20. Cortright DN, Nicoletti A, Seasholtz AF. Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein. Mol Cell Endocrinol 1995; 111: 147-157.
21. Sutton SW, Behan DP, Lahrichi SL, Kaiser R, Corrigan A, Lowry P, Potter E, Perrin M, Rivier J, Vale WW. Ligand requirements of the human corticotropin-releasing factor binding protein. Endocrinology 1995; 136: 1097-1102.
22. Potter E, Sutton S, Donaldson C, Chen R, Perrin M, Lewis K, Sawchenko PE, Vale W. Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary. Proc Natl Acad Sci USA 1994; 91: 8777-8781.
23. Linton EA, AVP, Woods RJ, Eben F, Wolfe CDA, Behan DP, Potter E, Vale VW, Lowry PJ. Corticotropin releasing hormone-binding protein (CRH-BP); plasma levels decrease during the third trimester of normal human pregnancy. J Clin Endocrinol Metab 1993; 76: 260-262.
24. Woods AJ, Stock MJ. Leptin activation in the hypothalamus. Nature 1996; 381: 745.
25. Krahn DD, Gosnell BA. Behavioral effects of corticotropin-releasing factor: localization and characterization of central effects. Brain Res 1988; 443: 63-69.
26. van Huijsduijnen OBH, Rohner-Jeanrenaud F, Jeanrenaud B. Hypothalamic neuropeptide Y messenger ribonucleic acid levels in preobese and genetically obese (fa/fa) rats; potential regulation thereof by corticotropin-releasing factor. J Neuroendocrinol 1993; 5: 381-386.
27. Liao N, Vaudry H, Pelletier G. Neuroanatomical connections between corticotropin-releasing factor (CRF) and somatostatin (SRIF) nerve endings and thyrotropin-releasing hormone neurons of the paraventricular nucleus of rat hypothalamus. Peptides 1992; 13: 677-680.
28. Lin L, York DA, Bray GA. Comparison of osborne-mendel and S5B/PL strains of rat: central effects of galanin, NPY, beta casomorphin and CRH on intake of high fat and low fat diets. Obesity Res 1996; 4: 117-124.
29. Bergh C, Sodersten P. Anorexia nervosa, self starvation and the reward of stress. Nature Med 1996; 2: 21-22.
30. Schwartz MW, Dallman MF, Woods SC. Hypothalamic response to starvation: implications for the study of wasting disorders. Am J Physiol 1995; 269: R949-R957.
31. Brown M, Fisher L, Spiess J, Rivier C, Rivier J, Vale W. Corticotropin-releasing factor: actions on the sympathetic nervous system and metabolism. Endocrinology 1982; 111: 928-931.
32. Brown MR, Fisher LA. Corticotropin-releasing factor: effects on the autonomic nervous system and visceral systems. Fed Proc 1985; 44: 243-248.
33. Rothwell N. Central effects of CRF on metabolism and energy balance. Neurosci Biobehav Rev 1989; 14: 263-271.
34. Hulsey MG, Pless CM, Martin RJ. ICV administration of anticorticotropin-releasing factor antisense oligonucleotide:effects on feeding behaviour and body weight. Regul Pept 1995; 59: 241-246.
35. Muglia L, Jacobson L, Dikkes P, Majzoub JA. Corticotropin-releasing hormone deficiency reveals major fetal but adult glucocorticoid need. Nature 1995; 373: 427-431.
36. Potter E, Behan D, Linton EA, Lowry PJ, Sawchenko PE, Vale WW. The central binding distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF. Proc Natl Acad Sci USA 1992; 89: 4192-4196.
37. Behan DP, Heinrichs SC, Troncoso JC, Liu X-J, Kawas CH, Ling N, De Sousa EB. Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. Nature 1995; 378: 284-287.
38. Thakore JH, Dinan TG. Growth hormone secretion: the role of glucocorticoids. Life Sci 1994; 55: 1083-109.
39. Joels M, de Kloet FR. Corticosteroid hormones: endocrine messengers in the brain. News Physiol Sci 1995; 10: 71-76.
40. Conover CA, Clarkson JT, Bale LK. Effect of glucocorticoid on insulin-like growth factor (IGF) regulation on IGF-binding protein expression in fibroblasts. Endocrinology 1995; 136: 1403-1410.
41. Gronowicz GA, McCarthy MB. Glucocorticoids inhibit the attachment of osteoblasts to bone extracellular matrix proteins and decrease β-integrin levels. Endocrinology 1995; 136: 598-608.
42. Loeb JN. Corticosteroids and growth hormone. N Engl J Med 1976; 295: 547-552.
43. Palmiter RD, Sangren EP, Koeller DM, Brinster RL. Distal regulatory elements from tthe mouse metallothionein locus stimulate gene expression in transgenic mice. Mol Cell Biol 1993; 13: 5266-5275.
44. Durnam DM, Hoffman JS, Quaife CJ, Benditt EP, Chen HY, Brinster RL, Palmiter RD. Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones. Proc Natl Acad Sci USA 1984; 81: 1053-1056.
45. Friedman RL, Stark GR. α-Interferon induced transcription of HLA and metallothionein genes containing homologous upstream sequences. Nature 1985; 314: 637-639.
46. Richards RI, Heguy A, Karin M. Structural and functional analysis of the human metallothionein IA gene. Differential induction by metal ions and glucocorticoids. Cell 1984; 37: 263-272.
47. Peterson MG, Mercer JFB. Differential expression of 4 linked sheep metallothionein genes. Eur J Biochem 1988; 174: 425-429.
48. Linton EA, Behan DP, Saphier PW, Lowry PJ. Corticotropin-releasing hormone (CRH)-binding protein: reduction in the adrenocorticotropin-releasing activity of placental but not hypothalamic CRH. J Clin Endocrinol Metab 1990; 70: 1574-1580.
49. Kitay JI. Pituitary adrenal function in the rat after gonadectomy and gonadal hormone replacement. Endocrinology 1963; 73: 253-260.
50. Viau V, Meany MJ. Variations in the hypothalamic-pituitary adrenal responses to stress during the estrous cycle in the rat. Endocrinology 1991; 129: 2503-2511.
51. Burgess LH, Handa RJ. Chronic estrogen induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor mediated functions in female rats. Endocrinology 1992; 131: 1261-1269.
52. Critchlow V, Liebelt RA, Bar-sela M, Mountcastle W, Lipscomb HS. Sex differences in resting pituitary adrenal functions in the rat. Am J Physiol 1963; 205: 807-815.
53. Gaskin JH, Kitay JI. Hypothalamic and pituitary regulation of adrenocortical function in the hamster: effects of gonadectomy and gonadal hormone replacement. Endocrinology 1971; 1047-1053.
54. Haleem DJ, Kennett G, Curzon G. Adaption of female rats to stress: shift to male pattern by inhibition of corticosterone synthesis. Brain Res 1988; 458: 339-347.
55. Bingaman EW, Magnuson DJ, Gray TS, Handa RJ. Androgen inhibits the increases in hypothalamic corticotropin-releasing hormone (CRH) and CRH-immunoreactivity following gonadectomy. Neuroendocrinology 1994; 59: 228-234.
56. Nappi RE, Petraglia F, Guo AL, Criscuolo M, Trentini GP, Genazzani AR. Estrous cycle- and acute stress-related changes of rat ovarian immunoreactive corticotropin-releasing factor. Gynecol Endocrinol 1996; 10: 75-82.
57. Nappi RE, Rivest S. Ovulatory cycle influences the stimulatory effect of stress on the expression of corticotropin-releasing factor receptor messenger ribonucleic acid in the paraventricular nucleus of the female rat hypothalamus. Endocrinology 1995; 136: 4073-4083.
58. Vamvakopoulos NC, Chrousos GP. Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimorphism of the stress response and immune/inflammatory reaction. J Clin Invest 1993; 92: 1896-1902.
59. Guo AL, Petraglia R, Criscuolo M, Ficarra G, Nappi RE, Palumbo M, Valentini A, Genazzani AR. Acute stress- or lipopolysaccharide-induced corticosterone secretion in female rats is independent of the estrous cycle. Eur J Endocrinol 1994; 131: 535-539.
60. Spinedi E, Salas M, Chisari A, Perone M, Carino M, Gaillard RC. Sex differences in the hypthalamo-pituitary adrenal axis response to inflammatory and neuroendocrine stressors- evidence for a pituitary defect in the autoimmune disease susceptible female Lewis rat. Neuroendocrinology 1994; 60: 913-951.
61. Nakajima K, Suzuki K. Immunocytochemical detection of metallothionein in brain. Neurochem Int 1995; 27: 73-87.
62. Behan DP, Maciejewski D, Chalmers D, De Souza EB. Corticotropin-releasing factor binding protein (CRF-BP) is expressed in neuronal and astrocytic cells. Brain Res. 1995; 698: 259-264.
63. Glanville N, Durnam DM, Palmiter RD. Structure of mouse metallothionein-I gene and its mRNA. Nature 1981; 292: 267-269.
64. Vale W, Vaughan J, Yamamoto G, Bruhn T, Douglas C, Dalton D, Rivier C, Rivier J. Assay of corticotropin-releasing factor. Meth Enzymol 1983; 103H: 565-577.
65. Kramer CY. Extension of multiple range tests to group means with unequal numbers of replications. Biometrics 1956; 12: 207-310.