Dermal toxicity: Alternative methods for risk assessment

Environmental Health Perspectives

Volumn 106, Issue SUPPL. 2, 1998, Pages 493-496

  Goldberg, Alan M ^a   Maibach, Howard I ^b  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Allergic contact dermatitis (ADC); Dermal; In vitro; Irritation; Sensitation; Skin

Indexed keywords

CONFERENCE PAPER; CONTACT DERMATITIS; IRRITANT DERMATITIS; PRIORITY JOURNAL; RISK ASSESSMENT; SKIN TOXICITY; TOXICITY TESTING;

EID: 0031832804     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106493     Document Type: Conference Paper

References (36)

1. Rougier A, Goldberg AM, Maibach HI, eds. Alternative Methods in Toxicology. Vol 10:In Vitro Skin Toxicology, Irritation, Phototoxicity, Sensitization. New York: Mary Ann Liebert, 1994.
2. Muller-Decker K, Furstenberger G, Marks F. Keratinocytederived proinflammatory key mediators and cell viability as in vitro parameters of irritancy:a possible alternative to the Draize skin irritation test. Toxicol Appl Pharmacol 127:99-109 (1994).
3. Basketter DA, Scholes EU, Chamberlain M, Barratt MD. An alternative strategy to the use of guinea pigs for the Identification of skin sensitization hazard. Food Chem Toxicol 33(12):1051-1056, (1995).
4. Barratt MD. Quantitative structure-activity relationships (QSARs) for skin corrosivity of organic acids, bases and phenols:principal components and neural network analysis of extended datasets. Toxicol In Vitro 10:85-94 (1996).
5. Barratt MD. Quantitative structure-activity relationships for skin irritation and corrosivity of neutral and electophilic organic chemicals. Toxicol In Vitro 10:247-256 (1996).
6. Magee PS, Hostynek JT, Maibach HI. Methods in Toxicology. Vol 10:In Vitro Skin Toxicology (Rougier A, Goldberg AM, Maibach HI, eds). New York: Mary Ann Liebert, 1994;281-291.
7. Liebsch M, Spielmann H, Balls M, Brand M, Doring B, Dupuis J, Holzhutter HG, Klecak G, L'Eplattenier H, Lov ell WW et al. First results of the EC/Colipa Validation Project "In Vitro Phototoxicity Testing." In:Alternative Methods in Toxicology. Vol 10:In Vitro Skin Toxicology (Rougier A, Goldberg AM, Maibach HI, eds). New York: Mary Ann Liebert, 1994;243-251.
8. Spielmann H, Balls M, Pechovitch J, Dupuis J, De Silva O, Pape WJW, Holzhutter HG. A validation study of in vitro photoirritation tests in a joint EU/Colipa project:preliminary report. In:Proceedings of the 2nd world Congress on Alternatives to Animal Use in the Life Sciences, Utrecht, The Netherlands, October 1996. Amsterdam:lsevier Science Publishers, 1997.
9. Elmets C. Progress in the development of an in vitro assay for contact allergens:results of the Avon Program Project experience. In Vitro Toxicol 9:223 (1996).
10. Shelley WB, Juhlin L. Langerhans cells form a reticuloepithelial trap for external contact antigens. Nature (London) 261:46-47 (1976).
11. Silberberg-Sinakin I, Thorbecke GJ, Baer RL, Rosenthal SA, Berezowsky V. Antigen-bearing Langerhans cells in skin, dermal lymphatics and in lymph nodes. Cell Immunol 25:137-151 (1976).
12. Sullivan S, Bergstresser PR, Tigelaar RE, Streilein JW. Induction and regulation of contact hypersensitivity by resident, bond marrow-derived, dendritic epidermal cells:Langerhans cells and Thy-1+ epidermal cells. J Immunol 137:2460-2467 (1986).
13. Hauser C, Sting, G. The skin immune response. In:Photoimmunlogy (Krutmann J, Elmets CA, eds). Oxford:Blackwell Science, 1995;3-18.
14. Macatonia SE, Knight SC, Edwards AJ, Griffiths S, Fryer P. Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies. J Exp Med 166:1654-1667 (1987).
15. Dai R, Grammar SF, Streilein JW. Fresh and cultured Langerhans cells display differential capacities to activate hapten-specific T cells. J Immunol 150:59-66 (1993).
16. Schuler G, Steinman RM. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med 161:526-546 (1985).
17. Aiba S, Katz SI. Phenotypic and functional characteristics of in vivo-activated Langerhans cells. J Immunol 145:2791-2796 (1990).
18. Cumberbatch M, Peters SW, Gould SJ, Kimber I. Intercellular adhesion molecule-1 (ICAM-1) expression by lymph node dendritic cells:comparison with epidermal Langerhans cells. Immunol Lett 32:105-110 (1992).
19. Teunissen MB, Rongen HA, Bos JD. Function of adhesion molecules lymphocyte function-associated antigen-3 and intercellular adhesion molecule-1 on human epidermal Langerhans cells in antigen-specific T cell activation. J Immunol 152:3400-3409 (1994).
20. Larsen CP, Ritchie SC, Hendrix R, Linsley PS, Hathcock KS, Hodes RJ, Lowry RP, Pearson TC. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J Immunol 152:5208-5219 (1994).
21. Lee MG, Borkowski TA, Udey MC. Regulation of expression of B7 by marine Langerhans cells:a direct relationship between B7 mRNA levels and the level of surface expression of B7 by Langerhans cells. J Invest Dermatol 101:883-886 (1993).
22. Kampgen E, Koch N, Koch F, Stoger P, Heufler C, Schuller G, Romani N. Class II major histocompatibility complex molecules of murine dendritic cells:synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture. Proc Natl Acad Sci USA 88:3014-3018 (1991).
23. Tang A, Amagai M, Granger LG, Stanley JR, Udey MC. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature (London) 361:82-85 (1993).
24. Heufler C, Koch F, Schuler G. Granulocyte/macrophage colony-stimulating factor and interleukin-1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulator dendritic cells. J Exp Med 167:700-705 (1988).
25. Ferguson TA, Mizutani H, Kupper TS. Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo. Proc Natl Acad Sci USA 88:8072-8076 (1991).
26. Larsen CG, Anderson, AO, Oppenheim JJ, Matsushima K, Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-1 or tumour necrosis factor. Immunology 68:31-36 (1989).
27. Nickoloff BJ, Griffiths CE, Barker JN. The role of adhesion molecules, chemotactic factors, and cytokines in inflammatory and neoplastic skin disease - 1990 uptake. J Invest Dermatol 94:151S-157S (1990).
28. Bergstresser PR. Cytokine expression by epidermal cell subpopulations in allergic contact dermatitis. In:Alternative Methods in Toxicology. Vol 10:In Vitro Skin Toxicology (Rougier A, Goldberg AM, Maibach HI, eds). New York:ary Ann Liebert, 1994;303-311.
29. Chamberlain M, Earl L. Use of cell cultures in irritancy testing, In:Alternative Methods in Toxicology. Vol 10:In Vitro Skin Toxicology (Rougier A, Goldberg AM, Maibach HI, eds). New York: Mary Ann Liebert, 1994;59-67.
30. Goodwin BF, Roberts DW. Structure-activity relationships and allergic contact dermatitis. Food Chem Toxicol 24(7):795-798 (1986).
31. Hauser C, Saurat JH. Immunological principles of sensitization. In:Alternative Methods in Toxicology. Vol 10:In Vitro Skin Toxicology (Rougier A, Goldberg AM, Maibach, HI, eds). New York: Mary Ann Liebert, 1994;255-261.
32. Perkins MA, Osborne R, Johnson GR. Development of an in vitro method for skin corrosion testing. Fundam Appl Toxicol 31:9-18 (1996).
33. Shivji GM, Gupta AK, Sauder DN. Role of Cytokines in Irritant Contact Dermatitis. In:Alternative Methods in Toxicology. Vol 10:In Vitro Skin Toxicology (Rougier A, Goldberg AM, Maibach HI, eds). New York: Mary Ann Liebert, 1993;13-22.
34. NIEHS. Validation and Regulatory Acceptance of Toxicological Test Methods:A Report of the Ad Hoc Interagency Coordinating Committee on the Validation of Alternative Methods. NIH Publ 97-3981. Research Triangle Park, NC: National Institute of Environmental Health Sciences, 1997.
35. OECD. Final Report of OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods, 22-24 January 1996, Solna Sweden. Paris:Organisation for Economic Co-operation and Development, 1996.
36. Curren R, Bruner L, Goldberg A, Walum E. 13th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC):Validation and Acute Toxicity Testing. Environ Health Perspect 106(Suppl 2):419-425 (1998).