The contractile effect of fedotozine on guinea pig isolated intestinal cells is not mediated by kappa opioid receptors

Pharmacology

Volumn 56, Issue 6, 1998, Pages 281-284

  Coruzzi, G ^a   Morini, G ^a   Coppelli, G ^a   Bertaccini, G ^a,b  

^a UNIVERSITY OF PARMA   (Italy)

^b Faculty of Veternary Medicine   (Italy)

Author keywords

Fedotozine; Guinea pig; Isolated intestinal cells; Kappa opioid receptors

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ACETYLCHOLINE; FEDOTOZINE; KAPPA OPIATE RECEPTOR; NALOXONE;

ANIMAL TISSUE; ARTICLE; CELL SIZE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ILEUM; INTESTINE CELL; INTESTINE CONTRACTION; INTESTINE MUSCLE; MALE; NONHUMAN; PRIORITY JOURNAL;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ACETYLCHOLINE; ANALGESICS, NON-NARCOTIC; ANIMALS; BENZYL COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; ILEUM; INTESTINES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NALOXONE; NARCOTIC ANTAGONISTS; PROPYLAMINES; RECEPTORS, OPIOID, KAPPA;

EID: 0031832799     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028210     Document Type: Article

References (19)

1. Riviere PJM, Pascaud X, Le Gallou B, Junien JL: Effects of fedotozine (JO 1196) on intestinal motility in rats. Gastroenterology 1991; 100: A487.
2. Pascaud X, Honde C, Le Gallou B, Chanoine F, Roma F, Bueno L, Junien JL: Effects of fedotozine on gastrointestinal motility in dogs: Mechanism of action and related pharmacokinetics. J Pharm Pharmacol 1990;42:546-552.
3. Karaus M, Kittelman R, Lubke HJ, Erckenbrecht JF: Selective stimulation of phase 3 activity by fedotozine (JO 1196) in men. Gastroenterology 1990;98:A364.
4. Riviere PJM, Pascaud X, Chevalier E, Le Gallou B, Junien JL: Fedotozine reverses ileus induced by surgery or peritonitis: Action at peripheral k-opioid receptors. Gastroenterology 1993;104:724-731.
5. Riviere PJM, Pascaud X, Chevalier E, Junien JL: Fedotozine reversal of peritoneal-irritation-induced ileus in rats: Possible peripheral action on sensory afferents. J Pharmacol Exp Ther 1994;270:846-850.
6. Guè M, Pascaud X, Hondé C, Junien JL, Bueno L: Peripheral antagonistic action of trimebutine and κ opioid substances on acoustic stress-induced gastric motor inhibitions in dogs. Eur J Pharmacol 1988;146: 57-63.
7. Junien JL, Riviere PJM: Review article: The hypersensitive gut. Peripheral kappa agonists as a new pharmacological approach. Aliment Pharmacol Ther 1995;9:117-126.
8. Coffin B, Bouhassira D, Chollet R, Fraitag B, De Meynard C, Geneve J, Lemann M, Willer JC, Jian R: Effect of the kappa agonist fedotozine on perception of gastric distension in healthy humans. Aliment Pharmacol Ther 1996;10:919-925.
9. Fraitag B, Homerin M, Hecketsweiler P: Double-blind dose-response multicenter comparison of fedotozine and placebo in treatment of non-ulcer dyspepsia. Dig Dis Sci 1994;39:1072-1077.
10. Allescher HD, Ahmad S, Classen M, Daniel EE: Interaction of trimebutine and JO 1196 (fedotozine) with opioid receptors in the canine ileum. J Pharmacol Exp Ther 1991;257: 836-842.
11. Soulard CD, Guerif S, Payne A, Dahl SG: Differential effects of fedotozine compared to other kappa agonists on diuresis in rats. J Pharmacol Exp Ther 1996;279:1379-1385.
12. Lai J, Ma SW, Zhu RH, Rothman RB, Lentes KU, Porreca F: Pharmacological characterization of the cloned kappa opioid receptor as a kappa (1b) subtype. Neuroreport 1994;5:2161-2164.
13. Adami M, Bertaccini G, Roncoroni L, Cobianchi F: Effect of fedotozine on human distal colon. Ital J Gastroenterol 1996;28:441-446.
14. Poli E, Pozzoli C, Coruzzi G, Bertaccini G: Opioid receptors in the isolated guinea pig colon. Can J Physiol Pharmacol 1994;72(suppl 1):P6-1.
15. Kromer W: Endogenous and exogenous opioid in the control of gastrointestinal motility and secretion. Pharmacol Rev 1988;40:121-162.
16. Bitar KN, Makhlouf GM: Receptors on smooth muscle cells: Characterization by contraction and specific antagonists. Am J Physiol 1982;242: G400-G407.
17. von Voigtlander PF, Lathi RA, Ludens JH: U-50488: A selective and structurally novel non-μ (k) opioid agonist. J Pharmacol Exp Ther 1983;224:7-12.
18. Kojima Y, Takahashi T, Fujina M, Owyang C: Inhibition of cholinergic transmission by opiates in ileal myenteric plexus is mediated by kappa receptor. Involvement of regulatory inhibitory G protein and calcium N-channels. J Pharmacol Exp Ther 1994;268:965-970.
19. Bitar KN, Makhlouf GM: Selective presence opiate receptors on intestinal circular muscle cells. Life Sci 1985;37:1545-1550.