The effects of space flight on the production of monorden by Humicola fuscoatra WC5157 in solid-state fermentation

Applied Microbiology and Biotechnology

Volumn 49, Issue 5, 1998, Pages 579-583

  Lam, K S ^a   Mamber, S W ^a   Pack, E J ^a   Forenza, S ^a   Fernandes, P B ^b   Klaus, D M ^c  

^a BRISTOL MYERS SQUIBB   (United States)

^b Small Molecule Therapeutics   (United States)

^c University of Colorado   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RADICICOL; UNCLASSIFIED DRUG;

ARTICLE; BIOMASS; CANDIDA ALBICANS; DRUG MANUFACTURE; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMICOLA FUSCOATRA; MASS SPECTROMETRY; MICROGRAVITY; NONHUMAN; SPACE FLIGHT;

FLIGHT EXPERIMENT; MANNED; SHORT DURATION; STS-77 SHUTTLE PROJECT;

ANTIBIOTICS, ANTIFUNGAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FERMENTATION; LACTONES; MACROLIDES; MASS SPECTROMETRY; MITOSPORIC FUNGI; SPACE FLIGHT;

EID: 0031832756     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530051216     Document Type: Article

References (21)

1. Ayer WA, Lee, SP (1980) The isolation, identification, and bioassay of the antifungal metabolites produced by Monocillium nordinii. Can J Microbiol 26: 766-773
2. Bouloc P, D'Ari, R (1991) Escherichia coli metabolism in space. J Gen Microbiol 137: 2389-2843
3. Ciferri O, Tiboni O, DiPasquale G, Orlandoni AM, Marchesi ML (1986) Effects of microgravity on genetic recombination in Escherichia coli. Naturwissenchaften 73: 418-421
4. Cutler HG, Arrendale RF, Springer JP, Cole PD, Roberts DG, Hanlin RT (1987) Monorden from a novel source, Neocosmospora tenuicristata: stereochemistry and plant growth regulatory properties. Agric Biol Chem 51: 3331-3338
5. Fang A, Pierson DL, Mishra SK, Koenig DW, Demain AL (1997a) Secondary metabolism in simulated microgravity: β-lactam production by Streptomyces clavuligerus. J Ind Microbiol Biotechnol 18: 22-25
6. Fang A, Pierson DL, Mishra SK, Koenig DW and Demain AL (1997b) Gramicidin S production by Bacillus brevis in simulated microgravity. Curr Microbiol 34: 199-204
7. Fang A, Pierson, Pierson DL, Koenig DW, Mishra SK, Demain AL (1997c) Effect of simulated microgravity and shear stress on microcin B17 production by Escherichia coli and on its excretion into the medium. Appl Environ Microbiol 63: 4090-1092
8. Gasset G, Tixador R, Eche B, Lapchine L, Moatti N, Toorop P, Woldringh C (1994) Growth and division of Escherichia coli under microgravity conditions. Res Microbiol 145: 111-120
9. Hege-Treskatis D, King R, Wolf H, Gilles E-D (1992) Nutritional control of nikkomycin and juglomycin production by Streptomyces tendae in continuous culture. Appl Microbiol Biotechnol 36: 440-445
10. Klaus D, Simske S, Todd P, Stodieck L (1997) Investigation of space flight effects on Escherichia coli and a proposed model of underlying mechanisms. Microbiology (Reading) 143: 449-455
11. V-SRC protein kinase both in vivo and in vitro by radicicol. Can Res 52: 6926-6930
12. Lam KS, Veitch JA, Golik J, Rose WC, Doyle TW, Forenza S (1995) Production and isolation of two novel esperamicins in a chemically defined medium. J Antibiot (Tokyo) 48: 1497-1501
13. Mennigmann HD, Heise M (1994) Response of growing bacteria to reduction in gravity. Proceedings of the 5th European Symposium of Life Sciences Research in Space. SP-366. European Space Agency (ESA) Paris, France pp 83-87
14. Mennigmann HD, Lange M (1986) Growth and differentiation of Bacillus subtilus under microgravity. Naturwissenschaften 73: 415-417
15. Mishra SK, Pierson DL (1992) Space flight effects on microorganisms. In: Lederberg J (ed) Encyclopedia of microbiology, vol 4. Academic Press, San Diego, Calif, pp 53-60
16. Myers-Keith P (1986) Method for increasing fertility in animals by controlling and stimulating ovulation with monorden manufactured by Diheterospora chlamydosporia. US patent 4707492
17. Oikawa T, Ito H, Ashino H, Toi M, Tominaga T, Morita I, Murota S (1993) Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur J Pharmacol 241: 221-227
18. Thévenet D, D'Ari R, and Bouloc P (1996) The SIGNAL experiment in BIORACK: Escherichia coli in microaravity. J Biotechnol 47: 89-97
19. Tixador R, Richoilley G, Gasset G, Templier J, Bes JC, Moatti N, Lapchine L (1985) Study of minimal inhibitory concentration of antibiotics on bacteria cultivated in vitro in space (Cytos 2 experiment). Aviat Space Environ Med 56: 748-751
20. Tixador R, Gasset G, Eche B, Moatti N, Lapchine L, Woldringh C, Toorop P, Moatti J, Delmotte F, Tap G (1994) Behavior of bacteria and antibiotics under space conditions. Aviat Space Environ Med 65: 551-556
21. Weinberg ED (1989) Roles of micronutrients in secondary metabolism of actinomcyetes. In: Shapiros S (ed) Regulation of secondary metabolism in actinomycetes. CRC Boca Raton, Fla, pp 239-261