Acute and chronic administration of clozapine produces greater proconvulsant actions than haloperidol on focal hippocampal seizures in freely moving rats

Synapse

Volumn 29, Issue 3, 1998, Pages 272-278

  Minabe, Yoshio ^a   Watanabe, Kei Ichiro ^a   Nishimuba, Tsutomu ^a   Ashby Jr , Charles R ^b  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b ST JOHN'S UNIVERSITY   (United States)

Author keywords

Clozapine; Epilepsy; Haloperidol; Hippocampus; Kindling

Indexed keywords

CLOZAPINE; HALOPERIDOL;

AFTERDISCHARGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; FOCAL EPILEPSY; GABAERGIC TRANSMISSION; HIPPOCAMPUS; KINDLING; MYOCLONUS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SEIZURE THRESHOLD;

ANIMALS; ANTIPSYCHOTIC AGENTS; CLOZAPINE; HALOPERIDOL; HIPPOCAMPUS; INJECTIONS, INTRAPERITONEAL; KINDLING, NEUROLOGIC; MALE; RATS; RATS, WISTAR; SEIZURES; TIME FACTORS;

EID: 0031832229     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199807)29:3<272::AID-SYN10>3.0.CO;2-V     Document Type: Article

References (62)

1. Arnold, P.S., Racine, R.J., and Wise, R.A. (1973) Effects of atropine, reserpine, 6-hydroxydopamine, and handling of seizure development in the rat. Exp. Neurol., 40:457-470.
2. 2 receptors in the medial prefrontal cortex: Microiontophoretic studies. Brain Res., 506:346-348.
3. Ashby, C.R. Jr., and Wang, R.Y. (1996) Pharmacological actions of the atypical drug clozapine: A review. Synapse, 24:349-394.
4. Ashby, C.R. Jr., Edwards, E., Harkins, K.L., and Wang, R.Y. (1989) Differential effect of typical and atypical antipsychotic drugs on the suppressant action of 2-methylserotonin on medial prefrontal cortical cells: A microiontophoretic study. Eur. J. Pharmacol., 166:583-584.
5. Ashby, C.R. Jr., Minabe, Y., Edwards, E., and Wang, R.Y. (1991) Comparison of the effects of various typical and atypical antipsychotic drugs on the suppressant action of 2-methylserotonin on medial prefrontal cortical cells in the rat. Synapse, 8:155-161.
6. Bradford, H.F. (1995) Glutamate, GABA and epilepsy. Prog. Neurobiol., 47:477-511.
7. Braestrup, C., and Squires, R.F. (1978) Pharmacological characterization of benzodiazepine receptors in the brain. Eur. J. Pharmacol., 48:263-270.
8. Brann, M.R., Buckley, N.J., and Bonner, T.I. (1988) The striatum and cerebral cortex express different muscarinic receptor mRNAs. FEBS Lett., 230:90-94.
9. Busber, M., Young, C.D., and Deutch, A.Y. (1997) Involvement of glutamatergic mechanisms in the biochemical actions of the atypical neuroleptic clozapine. Schizophr. Res., 24:74.
10. Corbett, R. (1995) Clozapine but not haloperidol antagonizes an MK-801 discriminative stimulus cue. Pharmacol. Biochem. Behav., 51:561-564.
11. Corcoran, M.E., Fibiger, H.C., McGeer, E.G., and Wada, J.A. (1974) Potentiation of amygdaloid kindling and metrazol-induced seizures by 6-hydroxydopamine in rat. Exp. Neurol., 45:118-133.
12. Daly, D.A., and Moghaddam, B. (1993) Actions of clozapine and haloperidol in the extracellular levels of excitatory levels of amino acids in the prefrontal cortex and striatum of the conscious animal. Neurosci. Lett., 152:61-64.
13. Denney, D., and Stevens, J.R. (1995) Clozapine and seizures. Biol. Psychiatry, 37:427-433.
14. Devinsky, O., Honigfeld, G., and Patin, J. (1991) Clozapine-related seizures. Neurology, 41:369-371.
15. Drew, K.L., O'Connor, W.T., Kehr, J., and Ungerstedt, U. (1990) Regional specific effects of clozapine and haloperidol on GABA and dopamine release in the basal ganglia. Eur. J. Pharmacol., 187:385-397.
16. Emori, K., Minabe, Y., Tanii, Y., and Kurachi, M. (1991) Effects of chronic treatment with haloperidol and methamphetamine on hippocampal kindled seizures in the cat. Epil. Res., 8:213-219.
17. Farber, N.B., Price, M.T., Labruyere, R., Nemnich, J., St. Peter, H., Wozniak, D.F., and Olney, J.W. (1993) Antipsychotic drugs block phencyclidine receptor mediated neurotoxicity. Biol. Psychiatry, 34:119-121.
18. 3H-GABA into rat brain synaptosomes. Acta Pharmacol. Toxicol., 42:73-76.
19. Gee, K.W., Killam, E.K., and Hollinger, M.A. (1983) Effects of haloperidol-induced dopamine receptor supersensitivity on kindled seizure development. J. Pharmacol. Exp. Ther., 225:70-76.
20. 3H]MK801-binding sites in the rat brain: A side-preference action in cortical areas. Brain Res., 762:216-218.
21. Glass, M., and Dragunow, M. (1995) Neurochemical and morphological changes associated with human epilepsy. Brain Res. Rev., 21:29-41.
22. Grace, G.M., Corcoran, M.E., and Skelton, R.W. (1990) Kindling with stimulation of dentate gyrus. I. Characterization of electrographic and behavioral events. Brain Res., 509:249-256.
23. Graham, S.R., and Kokkinidis, L. (1993) Clozapine inhibits limbic system kindling: Implications for antipsychotic action. Brain Res. Bull., 30:597-605.
24. Gunther, W., Baghai, T., Naber, D., Spatz, R., and Hippius, H. (1993) EEG alterations and seizures during treatment with clozapine. A retrospective study of 283 patients. Pharmacopsychiatry, 26:69-74.
25. Kane, J., Honigfeld, G., Singer, J., and Meltzer, H. Clozaril Collaborative Study Group (1988) Clozapine for the treatment-resistant schizophrenic: A double-blind comparison with chlorpromazine. Arch. Gen. Psychiatry, 45:789-796.
26. Levey, A.I. (1993) Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain. Life Sci., 52:441-448.
27. Lindgren, S. (1987) Lack of effects of apomorphine, haloperidol and clozapine on the synthesis and utilization of brain GABA. J. Neural Transm., 69:47-57.
28. Lindstrom, L.H. (1988) The effect of long term treatment with clozapine in schizophrenia: A retrospective study in 96 patients treated with clozapine for up to 13 years. Acta Psychiatr. Scand., 77:524-529.
29. Liukkonen, J., Koponen, J.H., and Nousiainen U. (1992) Clinical picture and long term course of epileptic seizures that occur during clozapine treatment. Psychiatry Res., 44:101-112.
30. 3H]gamma-aminobutyric acid (GABA) binding in the human brain. Brain Res., 163:77-87.
31. Lloyd, K.G., and Hornykiewicz, O. (1977) Effect of chronic neuroleptic or L-DOPA administration on GABA levels in the rat substantia nigra. Life Sci., 21:1489-1496.
32. Loscher, W., Honack, D., and Hashem, A. (1987) Anticonvulsant efficacy of clonazepam and the β-carboline ZK 93423 during chronic treatment in amygdala kindled rats. Eur. J. Pharmacol., 143:403-414.
33. Loscher, W., and Honack, D. (1991) Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine. J. Pharmacol. Exp. Ther., 256:432-440.
34. Lothman, E.W., Bertram, E.H. III, and Stringer, J.L. (1991) Functional anatomy of hippocampal seizures. Prog. Neurobiol., 37:1-82.
35. 3H]flunitrazepam by the atypical neuroleptic, clozapine. Neuropharmacology, 26:265-269.
36. Meldrum, B.S. (1992) Excitatory amino acids in epilepsy and potential novel therapies. Epilepsy Res., 12:189-196.
37. Meldrum, B.S. (1994) The role of glutamate in epilepsy and other CNS disorders. Neurology, 44(Suppl. 8):S14-S23.
38. Meltzer, H.Y., Bastani, B., Kwon, K., Ramirez, L., Burnett, S., and Sharpe, J. (1989) A prospective study of clozapine in treatment-resistant schizophrenic patients. Psychopharmacology, 99:S68-S72.
39. Minabe, Y., Tsutsumi, M., and Kurachi, M. (1988) Effects of chronic haloperidol treatment on amygdaloid seizure generation in cats. Psychopharmacology, 94:259-262.
40. Nelson, C.B., Augelli-Szafran, C.E., Schwartz, R.D., Penvose, J.R., Jaen, J.C., Wiley, J., and Frey, K.A. (1996) Pharmacological characterization of PD102807: An m4 selective muscarinic antagonist. Soc. Neurosci. Abstr., 22, abstr. no. 500.16.
41. Nestros, J.N. (1982) Benzodiazepines and GABA receptors are functionally related: Further electrophysiological evidence in vivo. Prog. Neuropsychopharmacol. Biol. Psychiatry, 6:417-420.
42. Ohman, R., Larsson, M., Nilsson, I.M., Engel, J., and Carlsson, A. (1977) Neurometabolic and behavioral effects of haloperidol in relation to drug levels in serum and brain. Naunyn Schmiedebergs Arch. Pharmacol., 299:105-114.
43. Olney, J.W., and Farber, N.B. (1994) Efficacy of clozapine compared with other antipsychotic drugs in preventing NMDA antagonist neurotoxicity. J. Clin. Psychiatry, 55:43-46.
44. Paxinos, G., and Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
45. Pehek, E.A., Yamamoto, B.K., and Meltzer, H.Y. (1991) The effect of clozapine on dopamine, 5-HT and glutamate release in the rat medial prefrontal cortex. Schizophr. Res., 4:323.
46. Racine, R.J. (1972) Modification of seizure activity by electrical stimulation. I. Afterdischarge threshold. Electroenceph. Clin. Neurophysiol., 31:281-294.
47. Rupniak, N.M.J., Kilpatrick, G., Hall, M.D., Jenner, P., and Marsden, C.D. (1984) Differential alteration in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats. Psychopharmacology, 84:512-519.
48. Rupniak, N.M.J., Hall, M.D., Mann, S., Fleminger, S., Kilpatrick, G., Jenner, P., and Marsden, C.D. (1985) Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat. Biochem. Pharmacol., 34:2755-2763.
49. Sato, M., and Nakashima, T. (1975) Secondary epileptogenesis, sleep and catecholamines. Can. Neurol. Sci., 2:439-446.
50. Sato, M., Tomoda, T., Hikasa, N., and Otsuki, S. (1980) Inhibition of amygdaloid kindling by chronic pretreatment with cocaine or methamphetamine. Epilepsia, 21:497-507.
51. Schmidt, W.J. (1986) Intrastriatal injection of DL-2-amino-5-phosphonovaleric acid (AP-5) induces sniffing stereotypy that is antagonized by haloperidol and clozapine. Psychopharmacology, 90:123-130.
52. Schmidt, W.J. (1991) The glutamatergic system as a target of antipsychotic drug action. In: Animal Models in Psychopharmacology, Advances in Pharmacological Sciences. B. Olivier, J. Mos, and J.L. Slagen, eds. Birkhauser, Basel, pp. 289-293.
53. Schmidt, W.J., Krahling, H., and Ruhland, M. (1987) Antagonism of AP-5- and amphetamine-induced behaviour by timelotem as compared with clozapine and haloperidol. Life Sci., 41:1909-1914.
54. Shorvon, S.D. (1992) Epidemiology and etiology of epilepsy. In: Diseases of the Nervous System, Clinical Neurobiology, Vol. II. A.K. Asbury, G.M. McKhann, and W.I. MacDonald, eds. W.B. Saunders, Philadelphia, pp. 896-905.
55. Squires, R.F., and Saederup, E. (1993) Mono-n-aryl ethylenediamine and piperazine derivatives are GABAA receptor blockers: Implications for psychiatry. Neurochem. Res., 18:787-793.
56. Stevens, J.R., Denney, D., and Szot, P. (1996) Kindling with clozapine: Behavioral and molecular consequences. Epilepsy Res., 26:295-304.
57. Watanabe, K., Minabe, Y., Katsumori, H., Ashby, C.R. Jr., and Narita, N. (1997) Serotonin receptors and rat hippocampal seizures. Soc. Neurosci, Abstr., 27, abstr. no. 386.1.
58. A receptors. Eur. J. Pharmacol., 314:319-323.
59. Yamamoto, B.K., and Cooperman, M.A. (1994) Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations. J. Neurosci., 14:4159-4166.
60. Yamamoto, B.K., Pehek, E.A., and Meltzer, H.Y. (1994) Brain region effects of clozapine on amino acid and monoamine transmission. J. Clin. Psychiatry, 55:8-14.
61. Zeng, X.P., Le, F., and Richelson, E. (1997) Muscarinic m4 receptor activation by some atypical antipsychotic drugs. Eur. J. Pharmacology, 321:349-354.
62. Zorn, S.H., Jones, S.B., Ward, K.M., and Liston, D.R. (1994) Clozapine is a potent and selective muscarinic m4 receptor agonist. Eur. J. Pharmacol. Mol. Pharmacol. Sect., 269:R1.