Exploration of glucose homeostasis during fasting in growth hormone- deficient children

Acta Paediatrica, International Journal of Paediatrics

Volumn 87, Issue 5, 1998, Pages 505-510

  Jaquet, D ^a   Touati, G ^a   Rigal, O ^a   Czernichow, P ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

Fasting; GH deficiency; Glucagon; Hypoglycaemia; Ketogenesis

Indexed keywords

GLUCAGON; GLUCOSE; GROWTH HORMONE; KETONE; LACTIC ACID; PYRUVIC ACID;

ARTICLE; BRAIN METABOLISM; CHILD; CLINICAL ARTICLE; DIET RESTRICTION; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE UTILIZATION; GROWTH HORMONE DEFICIENCY; HUMAN; HYPOGLYCEMIA; KETOGENESIS; MALE; PRIORITY JOURNAL;

BLOOD GLUCOSE; CHILD; CHILD, PRESCHOOL; FASTING; FEMALE; GROWTH DISORDERS; HOMEOSTASIS; HUMAN GROWTH HORMONE; HUMANS; HYPOGLYCEMIA; INFANT; MALE; RISK;

EID: 0031831966     PISSN: 08035253     EISSN: None     Source Type: Journal    
DOI: 10.1080/08035259850158191     Document Type: Article

References (24)

1. Altszuler N. Actions of growth hormone and carbohydrate metabolism. Knobil E, Sawyer WH, editors. Handbook of physiology, Section 7, vol. 4, Washington DC: American Physiological Society, 1974: 233-52
2. Davidson MB. Effects of growth hormone administration to hypophysectomized rats on muscle lipid metabolism. Metabolism 1979; 28: 729-34
3. Fineberg SE, Merimee TJ. Acute metabolic effects of human growth hormone. Diabetes 1974; 23: 499-504
4. Goodman HM. Effects of growth hormone on glucose utilization in diaphragm muscle in the absence of increased lipolysis. Endocrinology 1967; 81: 1099-103
5. Altszuler N, Rathgeb I, Winkber B, De Bodo RC, Steel R. The effects of growth hormone on carbohydrate and lipid metabolism in the dog. Ann NY Acad Sci 1968; 148: 441-58.
6. Campbell J, Rastogi KS. Actions of growth hormone: enhancement of insulin utilization with inhibition of insulin effect on blood glucose in dogs. Metabolism 1969; 18: 930-44
7. Pierluissi J, Campbell J. Metasomatotropic diabetes and its induction: basal insulin secretion and insulin release responses to glucose, glucagon arginine and meals. Diabetologia 1980; 18: 223-8
8. Brasel JA, Wright JC, Wilkins L. An evaluation of 75 patients with hypopituitarism beginning in childhood. Am J Med 1965; 38: 484-98
9. Goodman H, Grumbah MM, Kaplan SL. Growth and growth hormone II: A comparison of isolated hormone deficiency and multiple pituitary hormone deficiency in 35 patients with idiopathic hypopituitary dwarfism. N Engl J Med 1968; 27: 57-68
10. Haymond MW, Karl I, Weldon W, Pagliara AS. The role of growth hormone and cortisone on glucose and gluconeogenic substrate regulation in fasted hypopituitary children. J Clin Endocrinol Metabol 1976; 42: 846-56
11. Hopwood NJ, Forsman PJ, Kenny FM, Drash AL. Hypoglycemia in hypopituitary children. Am J Child 1975; 129: 918-26
12. Wolfsdorf JI, Sadeghi-Nejad A, Senior B. Hypoketonemia and age related fasting hypoglycemia in growth hormone deficiency. Metabolism 1983; 32: 457-62
13. Bougnères PF, Artavia-Loria E, Ferre P, Chaussain JL, Job JC. Effects of growth hormone replacement therapy on the production and utilization of glucose in childhood. J Clin Endocrinol Metabol 1985; 61: 1152-7
14. Vassault A, Bonnefont JP, Specola N, Saudubray JM. Techniques in diagnostic human biochemical genetics. A laboratory manual, 1991: 285-308
15. Costin G, Kogut M, Frasier SD. Effects of low dose human growth hormone on carbohydrate metabolism in children with hypopituitarism. J Pediatr 1972; 80: 796-03
16. Underwood LE, Va Den Brande JL, Antony GJ, Voina SJ, Van Wyk JJ. Islet cell function and glucose homeostasis in hypopituitary dwarfism: synergism between growth hormone and cortisone. J Pediatr 1973; 82: 28-37
17. Koh THHG, Aynsley-Green A, Tarbit M, Eyre JA. Neural dysfunction during hypoglycemia. Arch Dis Child 1988; 63: 1353-8
18. Merimee TJ, Felig P, Marliss E, Fineberg E, Cahill GG. Glucose and lipid homeostasis in the absence of human growth hormone. J Clin Invest 1971; 50: 574-82
19. Robinson AM, Williamson DH. Physiological roles of ketone bodies as substrates and signals in mammalian tissues. Physiol Rev 1980; 60: 143-87
20. Saudubray J, Marsac C, Limal JM, Dumurgier E, Charpentier C, Ogier H, et al. Variation in plasma ketone bodies during a 24h fast in normal and hypoglycemic children: Relationship to age. J Pediatr 1981; 98: 904-8
21. Garg A, Grizzel WE, Kansal PC, Stabler T, Boots LR. Counter-regulatory hormone to insulin-induced acute hypoglycemia in hypopituitary patients. Horm Metabol Res 1994; 26: 276-82
22. Salomon F, Cuneo RC, Umpleby AM, Sönksen PH. Glucose and fat metabolism in adult with growth hormone deficiency. Clin Endocrinol 1994; 41: 315-22
23. McGarry JD, Wright P, Foster DW. Hormonal control of ketogenesis: rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon. J Clin Invest 1974; 55: 1202-9
24. Chaussain JL, Georges P, Calzada L, Job JC. Glycemic response to 24 H fast in normal children III: Influence of age. J Pediatr 1977; 91: 711-4