Effect of pregnancy on the metabolic clearance rate and the volume of distribution of oxytocin in the baboon

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 5 37-5, 1998, Pages

  Kowalski, Wlodzimierz B ^a   Diveky, Lubomir ^a   Mehendale, Ramkrishna ^a   Parsons, Michael ^b   Wilson Jr , Laird ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Metabolism; Pharmacokinetics; Volume of distribution

Indexed keywords

OXYTOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BABOON; BOLUS INJECTION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG METABOLISM; FEMALE; INFUSION; INTRAVENOUS DRUG ADMINISTRATION; METABOLIC CLEARANCE RATE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; STEADY STATE; TURNOVER TIME; UTERUS CONTRACTION;

EID: 0031831431     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.5.e791     Document Type: Article

References (19)

1. Amico, J. A, S. M. Seif, and A. G. Robinson. Oxytocin in human plasma: correlation with neurophysin and stimulation with estrogen. J. Clin. Endocrinol. Metab. 52: 988-993, 1981.
2. Amico, J. A., J. Seitchik, and A. G. Robinson. Studies on oxytocin in plasma of women during hypocontractile labor. J. Clin. Endocrinol. Metab. 58: 274-279, 1984.
3. Bernal, A. L., G. N. Europe-Finner, S. Phaneuf, and S. P. Watson. Preterm labour: a pharmacological challenge. Trends Pharmacol. Sci. 16: 129-133, 1995.
4. Claybaough, J. R., and C. F. T. Uyehara. Metabolism of neurohypophysial hormones. Ann. NY Acad. Sci. 689: 250-268, 1993.
5. Giussani, D. A., S. L. Jenkins, C. A. Mecenas, J. R. Owiny, R. A. Wentworth, J. A. Winter, J. B. Derks, M. Honnebier, and P. W. Nathanielsz. The oxytocin antagonist Atosiban prolongs gestation in the rhesus monkey (Abstract). J. Soc. Gynecol. Invest. 2: 265, 1995.
6. Hirst, J. J., G. J. Haluska, M. J. Cook, and M. J. Novy. Plasma oxytocin and nocturnal uterine activity: maternal but not fetal concentrations increase progressively during late pregnancy and delivery in rhesus monkeys. Am. J. Obstet. Gynecol. 169: 415-422, 1993.
7. Husslein, P., and H. Leitich. Some aspects on the mechanism of human labor and delivery. Eur. J. Obstet. Gynecol. Reprod. Biol. 59: S3-S7, 1995.
8. Johnston, J. M., and J. A. Amico. A prospective longitudinal study of the release of oxytocin and prolactin in response to infant suckling in long term lactation. J. Clin. Endocrinol. Metab. 62: 653-657, 1986.
9. Kowalski, W., S. C. Pak, M. Parsons, and L. Wilson, Jr. Apparent lack of circulating oxytocinase activity in the pregnant baboon (Abstract). Biol. Reprod. 54, Suppl. 1: 124, 1996.
10. Leake, R. D., R. E. Weitzman, and D. A. Fisher. Pharmacokinetics of oxytocin in the human subject. Obstet. Gynecol. 56: 701-704, 1980.
11. Lincoln, D. W., A. Hill, and J. B. Wakerley. The milk-ejection reflex of the rat: an intermittent function not abolished by surgical levels of anaesthesia. J. Endocrinol. 57: 459-476, 1973.
12. Meyer, C., M. J. Freund-Mercier, Y. Guerne, and P. H. Richard. Relationship between oxytocin release and amplitude of oxytocin cell neurosecretory bursts during suckling in the rat. J. Endocrinol. 114: 263-270, 1987.
13. Rowland, M., and T. N. Tozer. Distribution kinetics. In: Clinical Pharmacokinetics: Concepts and Applications (3rd ed.). Baltimore, MD: Williams & Wilkins, 1995, p. 313-328.
14. Soloff, M. S. The role of oxytocin in the initiation of labor, and oxytocin-prostaglandin interactions. In: The Onset of Labor: Cellular and Integrative Mechanisms, edited by D. McNellis, J. R. G. Challis, P. C. MacDonald, P. W. Nathanielsz, and J. M. Roberts. Ithaca, NY: Perinatology, 1988, p. 87-123.
15. Thornton, S., J. M. Davison, and P. H. Baylis. Effect of human pregnancy on metabolic clearance rate of oxytocin. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R21-R24, 1990.
16. Walter, R., and W. H. Simmons. Metabolism of neurohypophyseal hormones: considerations from a molecular viewpoint. In: Neurohypophysis, edited by A. M. Moses and L. Share. Basel, Switzerland: Karger, 1977, p. 167-188.
17. Wilson, L., Jr., and M. T. Parsons. Endocrinology of human gestation. In: Reproductive Endocrinology, Surgery and Technology, edited by E. Y. Adashi, J. A. Rock, and Z. Rosenwaks. Philadelphia, PA: Lippincott-Raven, 1996, p. 452-475.
18. Wilson, L., Jr., M. T. Parsons, and G. Flouret. Inhibition of spontaneous uterine contractions during the last trimester in pregnant baboons by an oxytocin antagonist. Am. J. Obstet. Gynecol. 163: 1875-1882, 1990.
19. Wilson, L., Jr., M. T. Parsons, and G. Flouret. Forward shift in the initiation of the nocturnal estradiol surge in the pregnant baboon: is this the genesis of labor? Am. J. Obstet. Gynecol. 165: 1487-1498, 1991.