Inhibition of NNK-induced lung tumorigenesis by modulators of NNK activation

Experimental Lung Research

Volumn 24, Issue 4, 1998, Pages 595-604

  Morse, Mark A ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Indoles; Isothiocyanates; Limonene; Mouse lung; NNK; PEITC

Indexed keywords

INDOLE; ISOTHIOCYANIC ACID; LIMONENE; NITROSAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; DNA ADDUCT; DNA METHYLATION; DNA REPAIR; DRUG METABOLISM; ENZYME INHIBITION; ENZYME SUBSTRATE; GENETIC SUSCEPTIBILITY; LUNG CARCINOGENESIS; LUNG TUMOR; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031831291     PISSN: 01902148     EISSN: None     Source Type: Journal    
DOI: 10.3109/01902149809087388     Document Type: Conference Paper

References (22)

1. Hoffmann D, Hecht SS. Smokeless tobacco and cancer, ISI Atlas of Science: Pharmacology. 1998:46-52.
2. International Agency for Research on Cancer: Evaluation of the carcinogenic risk of chemicals to humans: tobacco habits other than smoking; betel quid and areca-nut chewing; and some related nitrosamines. IARC Monogr. 1985;37:209-224.
3. Hecht SS, Morse MA, Amin SG, et al. Rapid single dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet. Carcinogenesis. 1989; 10:1901-1904.
4. Morse MA, Stoner GD. Cancer chemoprevention: Principles and prospects. Carcinogenesis. 1993;14:1737-1746.
5. Morse MA, Eklind KI, Toussaint M, Amin, SG, Chung, F-L. Characterization of a glucuronide metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its dose-dependent excretion in the urine of mice and rats. Carcinogenesis. 1990;10:1819-1823.
6. Hecht SS, Jordon KG, Choi C-I, Trushin N. Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice. Carcinogenesis. 1990;11:1017-1020.
7. 6-Methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung. Cancer Res. 1991 ;51 :5557-5561.
8. Hecht SS, Lin D, Castonguay A. Effects of α-deuterium substitution on the mutagenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Carcinogenesis. 1983;4:305-310.
9. Morse MA, Eklind KI, Amin SG, Hecht SS, Chung F-L. Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates. Carcinogenesis. 1989;10:1757-1759.
10. Marmur J. A procedure for the isolation of deoxyribonucleic acid from microorganisms. J Mol Biol. 1961;3:208-218.
11. Sebti SM, Pruess-Schwartz DM, Baird WM. Species- and length of exposure-dependent differences in the benzo[a]pyrene:DNA adducts formed in embryo cell cultures from mice, rats, and hamsters. Cancer Res. 1985;45:1594-1600.
12. Morse MA, LaGreca SD, Amin SG, Chung, F-L. Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice. Cancer Res. 1990;50:2613-2617.
13. Morse MA, Eklind KI, Hecht SS, et al. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res. 1991;51:1846-1850.
14. Morse MA, Toburen AL. Inhibition of metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by limonene. Cancer Lett. 1996;104:211-217.
15. Wattenberg LW, Coccia, JB. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone carcinogenesis in mice by d-limonene and citrus fruit oils. Carcinogenesis. 1991;12:115-117.
16. Wattenberg LW. Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds.J Natl Cancer Inst. 1978;58:395-398.
17. Wattenberg LW. Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice. Carcinogenesis. 1987;8:1971-1973.
18. Morse MA, Wang C-X, Stoner GD, et al. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate. Cancer Res. 1989;49:549-553.
19. 6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Cancer Res. 1989;49:2894-2897.
20. Smith TJ, Guo Z, Thomas PE, et al. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates. Cancer Res. 1990;50:6817-6822.
21. Smith TJ, Guo Z, Li C, Ning SM, Thomas PE, Yang CS. Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation in mouse by dietary phenethyl isothiocyanate. Cancer Res. 1993;53:3276-3282.
22. Guo Z, Smith TJ, Wang E, Eklind KI, Chung F-L, Yang CS. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis. 1993;14:1167-1173.