Influence of immunoadjuvants and a promiscous T-cell determinant on the immunogenicity of RESA peptide antigen of P. falciparum

International Journal of Immunopharmacology

Volumn 20, Issue 6, 1998, Pages 259-273

  Chaba, B ^a   Kumar, P ^a   Haq, W ^b   Sabhnani, L ^a   Rao, D N ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOLOGICAL ADJUVANT; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; IMMUNIZATION; IMMUNOGENICITY; IMMUNOPHARMACOLOGY; IN VITRO STUDY; MALARIA; MALARIA CONTROL; MEROZOITE; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTECTION;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADJUVANTS, IMMUNOLOGIC; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; EPITOPES, T-LYMPHOCYTE; FEMALE; IMMUNIZATION, SECONDARY; IMMUNOCONJUGATES; LIPOSOMES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

EID: 0031829664     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(98)00021-6     Document Type: Article

References (21)

1. Alonso, M. J., Gupta, R. K., Min, C., Siber, G. R. and Langer, R. (1994) Biodegradable microspheres as controlled release of tetanus toxoid delivery systems. Vaccine 12, 299-306.
2. Alving, C. R. (1991) Liposomes as carriers of antigens and adjuvants. J. Immunol. Meth. 140, 1-13.
3. Berzins, K., Perlmann, H., Wahlin, B., Carlsson, J., Wahlgren, M., Udomsang Petch, R., Bjorkman, A., Patarroyo, M. E. and Perlmann, P. (1986) Rabbit and human antibodies to a repeated amino acid sequence of a P. falciparum antigen Pf155, react with the native protein and inhibit the merozoite invasion. Proc. Natl. Acad. Sci. USA 83, 1065-1069.
4. Collins, W. E., Pappaioanou, M., Anders, R. F., Campbell, G. H., Brown, G. V. and Kemp, D. J., Broderson, J. R., Coppel, R. L., Ckinner, J. C., Procell, P. M., Favaloro, J. M., Corcoran, L. M., Nancy, S. F., Mitchell, M. A. and Campbell, C. C. (1988) Immunization trials with the ring-infected erythrocyte surface antigen of Plasmodium falciparum in owl monkey (Aotus vociferans) Am. J. Trop. Med. Hyg. 38(2), 268-282.
5. Coppel, R. L., Cowman, A. F., Anders, R. F., Bianco, A. E., Saint, R. B., Lingelbach, K. R., Kemp, D. J. and Brown, G. V. (1984) Immune sera recognize on erythrocytes a Plasmodium falciparum antigen composed of repeated amino acid sequences. Nature (Lond.) 310, 789-791.
6. Cowman, A. F., Coppel, R. L., Saint, R. B., Favaloro, J. F., Crewther, P. E., Stahl, H. D., Bianco, A. E., Brown, G. V., Anders, R. F. and Kemp, D. J. (1984) The ring infected erythrocyte surface antigen (RESA) polypeptide of Plasmodium falciparum contains two separate blocks of tandem repeats encoding antigenic epitopes that are naturally immunogenic in man. Mol. Bio. Med. 2, 207-221.
7. Friguet, B., Chaffotte, A. F., Djavadi-Ohaniance, L. and Goldberg, M. E. (1985) Measurement of the true affinity constant in solution of antigen-antibody complexes by enzyme linked immuno-sorbent assay. J. Immunol. Meth. 77, 305-319.
8. Gregoriadis, G. and Florence, A. T. (1993) Liposomal drug delivery systems: clinical, diagnostic and opthalmic applications, Drugs 45, 15-28.
9. Herrera, M. A., Rosero, F., Herrera, S., Caspers, P., Rotmann, D., Sinigalia, F. and Certa, U. (1992) Protection against malaria in Aotus monkeys immunized with a recombinant blood-stage antigen fused to a universal T-cell epitope: correlation of serum gamma interferon levels with protection. Infect. Immun. 60, 154-158.
10. Hui, G. S. N., Chang, S. P., Tam, L. Q., Kato, A., Case, S. E., Hashiro, C., Kotani, S., Shiba, T., Kusumpto, S. and Siddiqui, W. A. (1990) Characterization of antibody responses induced by different synthetic adjuvants to the Plasmodium falciparum major merozoite surface precursor protein gp195. In Modern approaches to new vaccines including prevention of AIDS. ed. F. Brown, R. M. Chanock, H. S. Ginsberg and R. A. Lerner, pp. 477-484. Cold Spring Harbor Laboratory, NY: Cold Spring Harbor, NY.
11. + T-cells in the murine response to Plasmodium chabaudi. Parasitol. Today 5, 362-364.
12. Pawan, K., Ivanov, B. B., Kabilan, L. and Rao, D. N. (1994) Construction of synthetic immunogen: use of a natural immunomodulator polytuftsin in malaria vaccines against RESA antigen of Plasmodium falciparum. Vaccine 16(9), 819-824.
13. Pawan, K. and Rao. D. N. (1997a) Potentiation of the immune response against RESA peptides by incorporating universal T-cell epitope (CS.T3) and an immunomodulator (polytuftsin) and delivery through liposomes. Am. J. Trop. Med. Hyg. (Manuscript communicated).
14. Pawan, K. and Rao. D. N. (1997b) Correlation of T cell response and lymphokine profile with RESA peptides containing a universal T-cell epitope and an immunopotentiator, polytuftsin. Am. J. Trop. Med. Hyg. (Manuscript communicated).
15. Perlmann, P., Berzins, K., Perlmann, H., Troye-Blomberg, M. Wahlgren, M. and Wahlin, B. (1988) Malaria vaccine: immunogen selection and epitope mapping. Vaccine 6, 183-187.
16. Perlmann, H., Perlmann, P., Berzins, K., Wahlin, B., Troye-Blomberg, M., Hagstedt, M., Anderson, I., Hogh, B., Peterson, E. and Bjorkman, A. (1989) Dissection of the human antibody response to the malaria antigen Pf155/RESA into epitope specific components. Immunol. Rev. 112, 115-132.
17. Schagger, H. and Von Jagow, G. (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 KDa. Anal. Biochem. 166, 368-379.
18. Sjolander, A., Lovgen, K., Stahl, S., Aslund, L., Hansson, M., Nygren, P. A., Larsson, M., Hagstedt, M., Wahlin, B., Berzins, K., Uhlen, M., Morein, B. and Perlmann (1991) High antibody responses in rabbits immunized with influenza virus ISCOMs containing a repeat sequence of the Plasmodium falciparum antigen Pf155/RESA. Vaccine 9, 443-450.
19. Sinigaglia, F., Guttinger, M., Kilgus, J., Doran, D. M., Matile, H., Etlinger, H., Trzeciak, A., Gillessen, D. and Pink, J. R. L. (1988) A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules. Nature 336, 778-780.
20. Turanek, J., Toman, M., Novak, J., Krehnak, V. and Horavova, P. (1994) Adjuvant effect of liposomes and ada-mantylamide dipeptide on antigenicity of entrapped synthetic peptide derived from HIV-1 transmembrane region glycoprotein gp41. Immunol. Letts. 39, 157-161.
21. Wahlgren, M., Bjorkman, A., Perlmann, H., Berzins, K. and Perlmann, P. (1986) Anti-Plasmodium falciparum antibodies acquired by residents in a holoendemic area of Liberia during development of clinical immunity. Am. J. Trop. Med. Hyg. 35, 22-29.