A prospective phase II trial of concomitant chemotherapy and radiotherapy with delayed accelerated fractionation in unresectable tumors of the head and neck

Head and Neck

Volumn 20, Issue 6, 1998, Pages 497-503

  Harrison, Louis B ^a,b   Raben, Adam ^a   Pfister, David G ^a   Zelefsky, Michael ^a   Strong, Elliot ^a   Shah, Jatin P ^a   Spiro, Ronald H ^a   Shaha, Ashok ^a   Kraus, Dennis H ^a   Schantz, Stimson P ^a   Carper, Elise ^a,b   Bodansky, Barbara ^a   White, Carol ^a,b   Bosl, George ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b BETH ISRAEL MEDICAL CENTER   (United States)

Author keywords

Chemotherapy; Head and neck cancer; Radiotherapy; Unresectable

Indexed keywords

CISPLATIN; MITOMYCIN C; VINBLASTINE;

ADOLESCENT; ADULT; AGED; ARTICLE; BLINDNESS; BONE NECROSIS; BRAIN NECROSIS; CANCER INHIBITION; CANCER LOCALIZATION; CANCER SURVIVAL; CEREBROSPINAL FLUID FISTULA; CLINICAL TRIAL; DOSE RESPONSE; FEMALE; GRANULOCYTOPENIA; HEAD AND NECK CARCINOMA; HUMAN; INOPERABLE CANCER; LUNG TOXICITY; MAJOR CLINICAL STUDY; MALE; MENINGITIS; METASTASIS; MUCOSA INFLAMMATION; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGNOSIS; RADIATION DOSE FRACTIONATION;

ADOLESCENT; ADULT; AGED; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CISPLATIN; COMBINED MODALITY THERAPY; DOSE FRACTIONATION; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MITOMYCINS; NEOPLASM STAGING; PALLIATIVE CARE; PILOT PROJECTS; PROSPECTIVE STUDIES; RADIATION-SENSITIZING AGENTS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 0031829250     PISSN: 10433074     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0347(199809)20:6<497::AID-HED2>3.0.CO;2-H     Document Type: Article

References (38)

1. Harrison LB, Pfister DG, Fass DE, et al. Concomitant chemotherapy-radiotherapy followed by hyperfractionated radiation therapy for advanced unresectable head and neck cancer. Int J Radiat Oncol Biol Phys 1991;21: 703-708.
2. Marcial VA. Ninth annual del Regato lecture: optimal multidisciplinary management of head and neck cancer. Int J Radiat Oncol Biol Phys 1987;13:393-401.
3. Glick JH, Taylor SG, IV. Integration of chemotherapy into a combined modality. Int J Rad One Biol Phys 1981;7: 229-242.
4. Percarpio B, Fischer JJ. Irradiation of advanced head and neck cancer with large daily fractions. Radiology 1976; 121:489-490.
5. Haas C, Anderson T, Byhard R, et al. Randomized neoadjuvant study of 5-FU and CDDP for patients with advanced resectable head and neck cancer. Proc Am Assoc Cancer Res 1986;27:185.
6. Jacobs C. The use of chemotherapy in combination with radiotherapy. In: Wolf GT, ed. The treatment of head and neck squamous cancers. Boston: Martinus Nijhoff, 1984: 265-286.
7. Knowlton AH, Percarpio B, Bobrow S, Fischer JJ. Methotrexate and radiation therapy in treatment of advanced head and neck tumors. Radiology 1975;116:709-712.
8. Taylor SG, IV, Applebaum E, Showel JL, et al. A randomized trial of adjuvant chemotherapy in head and neck cancer. J Clin Oncol 1985;3:672-679.
9. Al-Sarraf M, Pajak T, Marcial V, et al. Concurrent radiotherapy and chemotherapy with cis platin in inoperable squamous cell carcinoma of the head and neck. Cancer 1987;59:259-265.
10. Crissman J, Pajak T, Zarbo R, Marcial V, Al-Sarraf M. Improved response and survival to combined cis platin and radiation in non-keratinized squamous cell carcinoma of the head and neck. An RTOG study of 114 advanced stage tumors. Cancer 1987;59:1397.
11. Merlano M, Vitale V, Rosso R, et al. Treatment of advanced squamous cell carcinoma of the head and neck with alternating chemotherapy and radiotherapy. N Engl J Med 1992;327:1115-1121.
12. Jampolis S, Pipard G, Horiot JC, Bolla M, Ledorze C. Preliminary results using twice-a-day fractionation in the radiotherapeutic management of advanced cancers of the head and neck. Am J Roentgenol 1977;129:1091-1093.
13. Maciejewski B, Preuss-Bager G, Trott KR. The influence of number of fractions and overall treatment time on the local tumor control of cancer of the larynx. Int J Radiat Oncol Biol Phys 1983;9:321-328.
14. Medini E, Rao Y, Kim T, Jones TK, Levitt SH. Radiation therapy for advanced head and neck squamous cell carcinoma using twice-a-day fractionation. Radiology 1975; 116:709-712.
15. Parsons JT, Cassisi N, Million RR. Results of twice-a-day irradiation of squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 1984;10:2041-2051.
16. Wang CC, Blitzer PH, Suit H. Twice-a-day radiation for cancer of the head and neck. Cancer 1985;55:2100-2104.
17. Withers HR. Biological basis for altered fractionation schemes. Cancer 1985;55:2086-2095.
18. Wittes R, Brescia R, Young CW, Magill GB, Krakoff IH. Combination chemotherapy with cis-diamine-dichloro-platinum (II) and bleomycin in tumors of the head and neck. Oncology 1975;32:203-207.
19. Kaplan EL, Meier P. Non-parametric observation from incomplete observation. J Am Stat Assoc 1958;53: 457-481.
20. Marcial VA, Pajek TF, Mohiuddin M, et al. Concomitant chemotherapy and radiotherapy in advanced squamous cell carcinoma of the head and neck. Long term results of the RTOG follow-up study 81-17. Cancer 1990;66: 1861-1868.
21. Glick JH, Taylor SG, IV. Integration of chemotherapy into a combined modality treatment plan for head and neck cancer. A Review. Int J Radiol Oncol Biol Phys 1981;7: 229-242.
22. Million RR, Cassisi NJ, Wittes RE. Cancer of the head and neck. In: DeVita VT, Jr, Hellman S, Rosenberg SA, eds. Cancer: principles and practice of oncology, 2nd ed, Vol. 1. Philadelphia: J.B. Lippincott, 1985:407-506.
23. Percarpio B, Fischer JJ. Irradiation of advanced head and neck cancer with large daily fractions. Radiology 1976; 121:489-490.
24. Thames HD, Peters LJ, Withers HR, et al. Accelerated fractionation versus hyperfractionation: rationales for several treatments per day. Int J Radiol Oncol Biol Phys 1983;9:127-138.
25. Withers HR, Taylor JNG, Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 1988;27:131-146.
26. Maciejewski B, Preuss-Bager G, Trott KR. The influence of number of fractions and overall treatment time on the local tumor control of cancer of the larynx. Int J Radiat Oncol Biol Phys 1983;9:321-328.
27. Wang CC. Improved local control for advanced oropharyngeal carcinoma following twice-daily radiation therapy. Am J Clin Oncol 1985;8:512-516.
28. Peters LJ, Ang KK. The role of accelerated fractionation in head and neck cancers. Semin Radiat Oncol 1992;2: 180-194.
29. Ang KK, Peters LJ, Weber RS, et al. Concomitant boost radiotherapy schedules in the treatment of carcinoma of the oropharynx and nasopharynx. Int J Radiat Oncol Biol Phys 1990; 19:1339-1345.
30. Taylor SG, Murthy AK, Caldarelli DD, et al. Combined simultaneous cis platin/-flurouracil chemotherapy and split course radiation in head and neck cancer. J Clin Oncol 1991;14:273-279.
31. Head and Neck Contracts Program. Adjuvant chemotherapy for advanced head and neck squamous cell carcinomas. Cancer 1987;60:301-311.
32. Laramore GE, Scott CB, Al-Sarraf M, et al. Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: report on inter-group study 0034. Int J Radiat Oncol Biol Phys 1992;23:705-713.
33. Bedwinek JM, Peres CA, Keys DJ. Analysis of failure patterns after definitive irradiation for epidermoid carcinoma of the nasopharynx. Cancer 1980;45:2725-2729.
34. Hoppe RT, Goffinet DR, Bagshaw MA. Carcinoma of the nasopharynx: eighteen years experience with megavoltage radiation therapy. Cancer 1979;43:472-481.
35. Mesic JB, Fletcher GH, Goepfort H. Megavoltage irradiation of epithelial tumors of the nasopharynx. Int J Radiat Oncol Biol Phys 1981;7:447-453.
36. Fu KK. Treatment of tumors of the nasopharynx: radiation therapy. In: Thawley SE, Panje WR, eds. Comprehensive management of head and neck tumors, Vol. 1. Philadelphia: W.B. Saunders, 1987:649-662.
37. Harrison LB, Pfister DG, Kraus D, et al. Management of unresectable malignant tumors of the skull base using concomitant chemotherapy and radiotherapy with accelerated fractionation. Skull Base Surg 1994;4:127-131.
38. Choi KN, Rotman M, Aziz H, et al. Locally advanced paranasal sinus and nasopharynx tumors treated with hyperfractionated radiation and concomitant infusion cis platin. Cancer 1991;67:2748-2752.