2-pyrazolin-5-ones structurally related to certain analgesics and antipyretic drugs and their anti-inflammatory activity

Bollettino Chimico Farmaceutico

Volumn 137, Issue 6, 1998, Pages 204-205

  Mpango, G B ^a   Metwally, M A ^a  

^a MAKERERE UNIVERSITY   (Uganda)

Author keywords

Bioavailability; Bioequivalence; Compartmental model; Guide line; Non compartmental model; Pharmacokinetic analysis

Indexed keywords

2 PYRAZOLIN 5 ONE DERIVATIVE; ANTIINFLAMMATORY AGENT; CARRAGEENAN;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG STRUCTURE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; EDEMA; MALE; PYRAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031829171     PISSN: 00066648     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Korolkovas A., Essentials of Medicinal Chemistry, 2nd Ed., Wiley Interscience Publications, John Wiley & Sons, New York, Chrichester Brisbane, Toronto, Singapore, p. 73, 1988.
2. Hamor, G.H., Principles of Medicinal Chemistry (Foye, W.O. Ed.), 2nd Ed., Lea & Febiger, Philadelphia, p. 569 (1981).
3. Wiley R.H. and Wiley P., Pyrazolones, Pyrazolidones and Derivatives, Interscience Publishers, J. Wiley and Sons Inc., New York, 1964.
4. Stetter, H., and E. Rauscher, Chem. Ber., 93, 2054, 1960.
5. Burger, A., Medicinal Chemistry, 2nd Ed., p. 345, 1960.
6. Metwally M.A., Amer P.A., Afsah E.M. and Zimaity M.T., Boll. Chim. Farmaceutico, 134 (11), 616, 1995.
7. Amer F.A., Harhash A.H. adn Metwally M.A., Z. Naturaforsche, 32b, 943, 1977.
8. Mielens, Z.S., Drobeck H.P., Rozitis J. Jr and Sansone, V. J. Jr., Inhibition of Experimental Inflammation by Oral Toxic Agents. Toxical Appl. Pharmacol., 14, 293, 1969.