HLA class I (A, B) and II (DR, DQ) gene and haplotype frequencies in blood donors from Wales

Experimental and Clinical Immunogenetics

Volumn 15, Issue 2, 1998, Pages 69-83

  Darke, C ^a   Guttridge, M G ^a   Thompson, J ^a   McNamara, S ^a   Street, J ^a   Thomas, M ^a  

^a Welsh Blood Service   (United Kingdom)

Author keywords

Bone marrow donor panel; HLA class I; HLA class II; HLA population genetics; Welsh population

Indexed keywords

HLA A1 ANTIGEN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA B ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN;

ANTIGEN DETECTION; ARTICLE; BONE MARROW TRANSPLANTATION; DISEASE PREDISPOSITION; DONOR; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; HAPLOTYPE; HOMOZYGOSITY; HUMAN; NORMAL HUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; POPULATION GENETICS; PRIORITY JOURNAL; SEROLOGY; UNITED KINGDOM;

ADOLESCENT; ADULT; BLOOD DONORS; FEMALE; GENE FREQUENCY; GENES, MHC CLASS I; GENES, MHC CLASS II; HAPLOTYPES; HLA-A ANTIGENS; HLA-B ANTIGENS; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMERASE CHAIN REACTION; WALES;

EID: 0031829008     PISSN: 02549670     EISSN: None     Source Type: Journal    
DOI: 10.1159/000019057     Document Type: Article

References (56)

1. Dausset J, Colombani J (eds): Histocompatibility 1972. Copenhagen, Munksgaard, 1973.
2. Wakisaka A, Imanishi T, Saito N, Konoeda Y, Gojobori T: W5.1. Introduction to and organisation of the anthropology component; in Tsuji K, Aizawa M, Sasazuki T (eds): HLA 1991: Proceedings of the Eleventh International Histocompatibility Workshop and Conference. New York, Oxford University Press, 1992, vol 1, pp 623-626.
3. Parham P: HLA, anthropology, and transplantation. Transplant Proc 1993;25:159-61
4. Tiwari JL, Terasaki PI: HLA and disease associations. New York, Springer, 1985.
5. Takahashi K, Juji T, Miyazaki H: Determination of an appropriate size of unrelated donor pool to be registered for HLA-matched platelet transfusion. Transfusion 1987;27: 394-398.
6. Beatty PG, Mori M, Milford E: Impact of racial genetic polymorphism on the probability of finding an HLA-matched donor. Transplantation 1995;60:778-783.
7. Schipper RF, D'Amaro J, Oudshoorn M: The probability of finding a suitable related donor for bone marrow transplantation in extended families. Blood 1996;87:800-804.
8. Zachary AA, Steinberg AG, Bias WB, Leffell MS: The frequencies of HLA alleles and haplotypes and their distribution among donors and renal patients in the UNOS registry. Transplantation 1996;62:272-283.
9. Bodmer J, Bodmer WF: Population genetics of the HL-A system: A summary of data from the Fifth International Histocompatibility Testing Workshop. Israel J Med Sci 1973;9: 1257-1268.
10. Baur MP, Danilovs JA: Joint report: Population analysis of HLA-A,B,C, DR and other genetic markers; in Terasaki PI (ed). Histocompatibility Testing 1980. Los Angeles, UCLA Tissue Typing Laboratory, 1980, pp 955-993.
11. Bodmer JG: The HLA system: The HLA-DR antigens and HLA haplotypes in 24 populations; in Population Structures and Genetic Disorders. Proc 7th Sigrid Juselin Foundation 1978. London, Academic Press, 1981, pp 211-238.
12. Baur MP, Neugebauer M, Albert ED: Reference tables of two-locus haplotype frequencies for all MHC marker loci; in Albert ED, Baur MP, Mayr WR (eds): Histocompatibility Testing 1984. Berlin, Springer, 1985, pp 677-755.
13. Imanishi T, Akaza T, Kimura A, Tokunaga K, Gojobori T: W15.1 allele and haplotype frequencies for HLA and complement loci in various ethnic groups; in Tsuji K, Aizawa M, Sasazuki T (eds): HLA 1991: Proceedings of the Eleventh International Histocompatibility Workshop and Conference. New York, Oxford University Press, 1992, vol 1, pp 1065-1220.
14. Darke C, Dyer PA: Clinical HLA typing by cytotoxicity; in Dyer PA, Middleton D (eds): Histocompatibility Testing: A Practical Approach. Oxford, IRL Press, Practical Approach Series, 1993, pp 51-80.
15. Bodmer JG, Marsh SGE, Albert ED, Bodmer WF, Bontrop RE, Charron D, Dupont B, Erlich HA, Fauchet R, Mach B, Mayr WR, Parham P, Sasazuki T, Schreuder GMTh, Strominger JL, Svejgaard A, Terasaki PI: Nomenclature for factors of the HLA system, 1996. Tissue Antigens 1997;49:297-321.
16. Darke C: The HLA-B14 cross-reactive group. Tissue Antigens 1980;15: 389-397.
17. Darke C: The HLA-B12 and -B40 cross-reactive groups and their serological relationships. Tissue Antigens 1983;21:281-295.
18. Darke C: A reanalysis of the HLA-B7 cross-reactive group. Tissue Antigens 1983;22:326-334.
19. Darke C: A serological study of the HLA-B17 cross-reactive group. Tissue Antigens 1984;23:141-150.
20. Darke C: The multideterminant nature of the HLA-B gene product - A serological study, PhD thesis, London. 1984.
21. Fussell H, Thomas M, Street J, Darke C: HLA-A9 antibodies and epitopes. Tissue Antigens 1996;47: 307-312.
22. Darke C, Street J, Fussell H, Thomas M, Guttridge M, Goldberg TE, Arnett KL, Parham P: A new HLA-B44 variant (B44BO [B*4408]) identified by serology. Tissue Antigens 1997;50:32-37.
23. Darke C, Fussell H, Street J, Thomas M, Guttridge MG, Worwood M: Serological and molecular identification of an HLA-B8 variant - HLA-B8Jon [B*0802]. Exp Clin Immunogenet 1997;13:139-153
24. Thomas M, Street J, Fussell H, Guttridge M, Darke C: Distribution of the HLA-A9 antigen family (A23, A24 and A2403). Tissue Antigens 1996;48:586-588.
25. Fussell H, Thomas M, Street J, Darke C: Serological identification of a new HLA-B7 variant antigen - HLA-B7QTJI. Eur J Immunogenet 1994;21:23-31.
26. Hildebrand WH, Domena JD, Shen SY, Marsh SG, Bunce M, Guttridge MG, Darke C, Parham P: The HLA-B7Qui antigen is encoded by a subtype of HLA-B27 (B*2708). Tissue Antigens 1994;44:47-51.
27. Krausa P, Moses J, Bodmer W, Bodmer J, Browning M: HLA-A locus alleles identified by sequence specific PCR. Lancet 1993;341: 121-122.
28. Guttridge MG, Burr C, Klouda PT: Identification of HLA-B35, B53, B18, B5, B78 and B17 alleles by the polymerase chain reaction using sequence-specific primers (PCR-SSP). Tissue Antigens 1994;44:43-46.
29. Bunce M, O'Neill CM, Barnardo MCNM, Krausa P, Browning MJ, Morris PJ, Welsh KJ: Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 1995;46:355-367.
30. Olerup O, Zetterquist H: HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 1992;39:225-235.
31. Bunce M, Taylor CJ, Welsh KI: Rapid HLA-DQB typing by eight polymerase chain reaction amplifications with sequence-specific primers (PCR-SSP). Hum Immunol 1993;37:201-206.
32. Olerup O, Aldener A, Fogdell A: HLA-DQB1 and -DQA1 typing by PCR amplification with seqeunce-specific primers (PCR-SSP) in 2 hours. Tissue Antigens 1993;41: 119-134.
33. Savelkoul PHM, deBruyn-Geraets DP, van den Berg-Loonen EM: High resolution HLA-DRB1 SSP typing for cadaveric donor transplantation. Tissue Antigens 1995;45:41-48.
34. Albert ED, Mickey MR, McNicholas AC, Terasaki PI: Seven new HL-A specificities and their distribution in three races; in Terasaki PI (ed): Histocompatibility Testing 1970. Copenhagen, Munksgaard, 1970, pp 221-230.
35. Yasuda N, Kimura M: A gene counting method of maximum likelihood for estimating gene frequencies in ABO and ABO-like systems. Ann Hum Genet 1968;31:409-420.
36. Schipper RF, D'Amaro J, Bakker JT, Bakker J, van Rood JJ, Oudshoorn M: HLA gene and haplotype frequencies in Bone Marrow Donors Worldwide registries. Hum Immunol 1997;52:54-71.
37. Cavalli-Sforza LL, Bodmer WF: The genetics of human populations. San Francisco, Freeman, 1971.
38. Pearson K: On the criterion that a given system of deviations from the probable in the case of a corrected system of variables is such that it can reasonably be supposed to have arisen from random sampling. Phil Mag (Ser 5) 1900;50:157.
39. Petrie A: Lecture notes on medical tatistics. Oxford, Blackwell, 1987.
40. Schipper RF, Schreuder GMT, D'Amaro J, Oudshoorn M: HLA gene and haplotype frequencies in Dutch blood donors. Tissue Antigens 1996;48:562-574.
41. Watterson GA: Heterosis or neutrality? Genetics 1977;35:789-814.
42. Yasuda N, Tsuji K: A counting method of maximum likelihood for estimating haplotype frequency in the HL-A system. Jap J Hum Genet 1975;20:1-15.
43. Lewontin RC: The interaction of selection and linkage. I. General considerations; heterotic models. Genetics 1964;49:49-67.
44. Edwards JH: HL-A and disease the detection of associations. J Immunogenet 1974;1:249-257.
45. Schipper RF, Oudshoorn M, D'Amaro J, van der Zenden HGM, de Lange P, Bakker JT, Bakker J, van Rood JJ: Validation of large data sets, an essential prerequisite for data analysis: an analytical survey of the Bone Marrow Donors Worldwide. Tissue Antigens 1996; 47:169-178.
46. Guttridge MG, Darke C: Rare DRB1 and DQB1 haplotypes identified in 2908 random blood donors. Eur J Immunogenet 1996,23:78.
47. Marsh SGE: Nomenclature for factors of the HLA system, update May/June 1997. Tissue Antigens 1997;50:419-420.
48. Mine H, Ishikawa Y, Hojo M, Imashuku S, Tokunaga K, Juji T, Saji H, Yokoyama S: An HLA-B null allele (B*1526N) with a stop codon in exon 3 generated by point mutation. Tissue Antigens 1997;50:351-354.
49. Vilches C, Bunce M, de Pablo R, Murray AK, McIntyre CA, Kreisler M: Complete coding regions of two novel HLA-B alleles detected by phototyping (PCR-SSP) in the British Caucasoid population: B*5108 and B*5002. Tissue Antigens 1997; 50:38-41.
50. Rees T, Guttridge MG, Street J, Thomas M, Thompson J, Eyres R, Rees MT, Darke C: Identification and distribution of HLA-B*15 alleles in a random population. Eur J Immunogenet 1997;24:36.
51. Hildebrand WH, Madrigal JA, Belich MP, Zemmour J, Ward FE, Williams RC, Parham P: Serological cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups: Dominant epitopes of the α2 helix. J Immunol 1992;149:3563-3568.
52. Thompson J, Street J, Guttridge MG, Darke C: HLA-B*5002 sequence confirmation, population studies and serology Eur J Immunogenet 1998;25:77.
53. D'Amaro J: HLA polymorphisms in the Netherlands - A study in population and immuno-genetics; PhD thesis, Leiden, 1978.
54. Middleton D, Magor K, Williams F, Parham P: HLA-A*24 null alleles identified in Northern Ireland individuals. Eur J Immunogenet 1997; 24(suppl 1):19.
55. Williams F, Mallon E, Middleton D: Development of PCR-SSOP for HLA-A typing of bone marrow registry donors. Tissue Antigens 1997; 49.61-66.
56. Navarrete C, Pamphilon D, Darke C, Green R, Chapman C, McClelland M, Hazel R, Warwick R: Current status of the British Bone Marrow and Platelet Donor Panel. Royal College of Physicians of Edinburgh Consensus Conference on Unrelated Donor Bone Marrow Transplantation, October 1996. Blood Rev, in press.