Activation of a nonspecific cation current in rat cultured retinal pigment epithelial cells: Involvement of a G(αi) subunit protein and the mitogen-activated protein kinase signalling pathway

British Journal of Pharmacology

Volumn 124, Issue 6, 1998, Pages 1115-1122

  Ryan, Jennifer S ^a   Kelly, Melanie E M ^a,b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

G protein; GTP S; MAP kinase; Nonspecific cation current; Retinal pigment epithelium

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ANTIBODY; ASPARTIC ACID; CATION; DIBUTYRYL CYCLIC GMP; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MITOGEN ACTIVATED PROTEIN KINASE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; POTASSIUM ION; PROTEIN SUBUNIT; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONDUCTANCE; CONTROLLED STUDY; CYTOSOL; DIALYSIS; ION CURRENT; NONHUMAN; PATCH CLAMP; PHOSPHORYLATION; PIGMENT EPITHELIUM; PIPETTE; PRIORITY JOURNAL; RAT; RETINA CELL; SIGNAL TRANSDUCTION;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CATIONS; CELLS, CULTURED; CYCLIC GMP; ENZYME INHIBITORS; GTP-BINDING PROTEINS; PATCH-CLAMP TECHNIQUES; PIGMENT EPITHELIUM OF EYE; RATS; RATS, LONG-EVANS;

EID: 0031828999     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701936     Document Type: Article

References (45)

1. ALESSAI, D.R., CUENDA, A., COHEN, P., DUDLEY, D.T. & SALTIEL, A.R. (1995). PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinases kinase in vitro and in vivo. J. Bio. Chem., 270, 27489-27494.
2. BARRY, P. & LYNCH, J. (1991). Liquid junction potentials and small cell effects in patch-clamp analysis. J. Membr. Biol. 121, 107-117.
3. 2+-calmodulin-dependent protein kinase in human epithelial cells. J. Physiol. 488, 37-55.
4. BOTCHKIN, L.M. & MATTHEWS, G. (1993). Chloride current activated by swelling in retinal pigment epithelium cells. Am. J. Physiol., 265, C1037-C1045.
5. BREITWIESER, G.E. (1991). G protein-mediated ion channel activation. Hypertension, 17, 684-692.
6. BROWN, A.M. (1993). Membrance-delimited cell signaling complexes: direct ion channel regulation by G proteins. J. Membr. Biol., 131, 93-104.
7. CREPEL, V., PANENKA, W., KELLY, M.E.M. & MACVICAR, B.A. (1998). MAP and tyrosine kinases in the activation of astrocyte volume-activated chloride current. J. Neurosci., 18, 1196-1206.
8. DEARRY, A., EDELMAN, J.L. MILLER, S. & BURNSIDE, B. (1990). Dopamine induces light-adpative retinomotor movements in bullfrog cones via D2 receptors and in the retinal pigment epithelium via D1 receptors. J. Neurochem., 54, 1367-1378.
9. DUDLEY, D.T., PANG, L., DECKER, S.J., BRIDGES, A.J. & SALTIEL, A.R. (1995). A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci., U.S.A., 92, 7686-7689.
10. FOX, J.A., PFEFFER, B. & FAIN, G. (1988). Single-channel recordings from cultured human retinal pigment epithelium. J. Gen. Physiol., 91, 193-222.
11. FINN, J.T., GRUNWALD, M.E. & YAU, K-W. (1996). Cyclic nucleotide-gated ion channels: an extended family with diverse functions. Ann. Rev. Physiol., 58, 395-426.
12. GHOSH, A. & GREENBERG, M.E. (1995). Calcium signaling in neurons: Molecular mechanisms and cellular consequences. Science, 268, 239-247.
13. GUPTA, S.K., JOLLIMORE, C.A., MCLAREN, M.J., INANA, G. & KELLY, M.E.M. (1997). Mammalian retinal pigment epithelial cells in vitro respond to the neurokines ciliary neurotrophic factor and leukemia inhibitory factor. Biochem. Cell Biol., 75, 119-125.
14. HAGELUKEN, A., NURNBERG, B., HARHAMMER, R., GRUNBAUM, L., SCHUNACK, W. & SEIFERT, R. (1995). The class III antiarrhythmic drug amiodarone directly activates pertussis toxin-sensitive G proteins. Mol. Pharmacol. 47, 234-240.
15. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch., 391, 85-100.
16. HIDAKA, H., INAGAKI, M., KAWAMOTO, S. & SASAKI, Y. (1984). Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry, 23, 5036-5041.
17. + pump in frog retinal pigment epithelialum. Am. J. Physio., 254, C84-C98.
18. INOUE, M., OGAWA, K., FUJISHIRO, N., YANO, A. & IMANAGA, I. (1996). Role and source of ATP for activation of nonselective cation channels by AIF complex in guinea pig chromaffin cells. J. Membr. Biol., 154, 183-195.
19. JIANG, M., PANDEY S., TRAN, V.T. & FONG, H.K.W. (1991). Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells. Proc. Natl. Acad. Sci. U.S.A.. 88, 3907-3911.
20. a1-2 medaites renal LLC-PK1 growth by a Raf-independent activation of p42/p44 MAP kinase. Am. J. of Physiol., F272-F282.
21. KUSAKA, S., DABIN, I., BARNSTABLE, C.J. & PURO, D.G. (1996). cGMP-mediated effects on the physiology of bovine and human retinal Muller (glial) cells. J. Physiol., 497, 813-824.
22. LIDOFSKY, S.D., SOSTMAN, A. & FITZ, J.G. (1997). Regulation of cation-selective channels in liver cells. J. Membr. Biol., 157, 231-236.
23. 2+ /calmodulin dependent protein kinase II inhibitor KN-93. Biochem. Biophys. Res. Commun., 195, 608-615.
24. 2+ /calmodulin-dependent protein kinase inhibitors KN62 and KN93, and their inactive analogues KN04 and KN92, inhibit nicotinic activation of tyrosine hydroxylase in bovine chromaffin cells. Biochem. Biophys. Res. Commun., 221, 15-18.
25. +-permeant cation channel by stretch and cyclic AMP-dependent phosphorylation in renal epithelial A6 cells. J. Gen. Physiol., 110, 327-336.
26. MCNEIL, P.L., MURPHY, R.F., LANNI, F. & TAYLOR, D.L. (1984). A method for incorporating macromolecules into adherent cells. J. Cell Biol., 98, 1556-1564.
27. NASH, M.S. & OSBORNE, N.N. (1995). Pertussis toxin-sensitive melatonin receptors negatively couple to adenylate cyclase associated with cultured human and rat retinal pigment epithelial cells. Invest. Ophthal. Vis. Sci., 36, 94-103.
28. NEILL, J.M., THORNQUIST, S.C., RAYMOND, M.C., THOMPSON, J.T. & BARNSTABLE, C.J. (1993). RET-PE10: a 61 kDa polypeptide epitope expressed late during vertebrate RPE maturation. Invest. Opthalmol. Vis. Sci., 34, 453-462.
29. POYER, J.F., RYAN, J.S. & KELLY, M.E.M. (1996). G protein-mediated activation of a nonspecific cation current in cultured rat retinal pigment epithelial cells. J. Membr. Biol., 153, 13-26.
30. RODBELL, M. (1992). The role of GTP-binding in signal transduction: From the sublimely simple to the conceptually complex. Curr. Topics Cell Reg., 32, 1-47.
31. SMART, T.G. (1997). Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylation. Curr. Opin. Neurobiol., 7, 358-367.
32. STEINBERG, R.H. & MILLER, S.S. (1979). Transport and membrane properties of the retinal pigment epithelium. In The Retinal Pigment Epithelium. Zinn, K.M. & Marmor, M.F. pp. 192-204. Cambridge: Harvard University Press.
33. STRAUSS, O. & WIENRICH, M. (1993). Cultured retinal pigment epithelial cells from RCS rats expression increased calcium conductance compared with cells from non-dystrophic rats. Pflugers Arch., 425, 68-76.
34. STRAUSS, O., RICHARD, U. & WEINRICH, M. (1993). Voltage-dependent potassium currents in cultured human retinal pigment epithelial cells. Biochem. Biophys. Res. Commun. 191, 775-781.
35. STRAUSS, O., WEISER, T. & WIENRICH, M. (1994). Potassium currents in cultured cells of the rat retinal pigment epithelium. Comp. Biochem. Physiol., 109, 975-983.
36. TAO, Q.-P., RAFUSE, P.E. & KELLY, M.E.M. (1994). Potassium currents in rabbit retinal pigment epithelial cells. J. Membr. Biol., 141, 123-138.
37. THORESON, W.B. & CHACKO, D.M. (1997). Lysophosphatidic acid stimulates two ion currents in cultured human retinal pigment epithelial cells. Exp. Eye Res., 65, 7-14.
38. TOULLEC, D., PIANETTI, P., COSTE, H., BELLEVERGUE, P., GRANPERRET, T., AJAKANES, M., BAUDET, V., BOISSIN, P., BOURSIER, E., LORIOLLE, F., DUHAMEL, L., CHARON, D. & KIRILOVSKY, J. (1991). The bisindolylmaleimide GF 109203X is a potent and selective inhbitor of protein kinase C. J. Biol. Chem., 266, 15771-15781.
39. UEDA, Y. & STEINBERG, R.H. (1993). Voltage-operated calcium channels in fresh and cultured rat retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci., 34, 3408-3418.
40. UEDA, Y. & STEINBERG, R.H. (1994). Chloride currents in freshly isolated rat retinal pigment epithelial cells. Exp. Eye Res., 58, 331-342.
41. 2 receptor activation of nonselective cation channels in smooth muscle cells: calcium and Gi/Go requirements. Am. J. Physiol., 273, C500-C508.
42. WEI, J.Y., COHEN, E.D., YAN, Y.Y., GENIESER, H.G. & BARNSTABLE, C.J. (1996). Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1, N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site. Biochemistry, 35, 16815-16823.
43. WICKMAN, K. & CLAPHAM, D.E. (1995). Ion channel regulation by G proteins. Physiol. Rev., 75, 865-885.
44. YU, X-M., ASKLAN, R., KEILL II, G. & SALTER, M.W. (1997). NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science, 275, 674-678.
45. ZAUBERMAN, H. (1979). Adhesive forces between the retinal pigment epithelium and sensory retina. In The Retinal Pigment Epithelium, ed. Zinn, K.M. & Marmor, M.F. pp. 192-204. Cambridge: Harvard University Press.