HIV-1 protease regulation: The role of the major homology region and adjacent C-terminal capsid sequences

Journal of Biomedical Science

Volumn 5, Issue 4, 1998, Pages 305-308

  Gatlin, Joel ^a   Arrigo, Salvatore J ^a   Schmidt, Michael G ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Capsid; HIV 1 protease; Major homology region; Regulation

Indexed keywords

PROTEINASE; VIRUS PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME REGULATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; VIRUS CAPSID; VIRUS GENE;

EID: 0031827487     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/BF02255863     Document Type: Article

References (11)

1. Arrigo, SJ, Chen ISY. Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif. vpr, and env/vpu-2 RNAs. Genes Dev 5:808-819;1991
2. Gatlin J, Campbell LH, Schmidt MG, Arrigo SJ. Direct-rapid (DR) mutagenesis of large plasmids using PCR. Biotechniques 19:559-564;1995.
3. Gatlin J, Arrigo SJ, Schmidt MG. Regulation of intracellular human immunodeficiency virus type-1 protease activity. Virology 244:87-96;1998.
4. Gottlinger HG, Sodroski JG, Haseltine WA. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 86:5781-5785;1989.
5. Huang M, Martin MA. Incorporation of Pr160(gag-pol) into virus particles requires the presence of both the major homology region and adjacent C-terminal capsid sequences within the Gag-Pol polyprotein. J Virol 71: 4472-4478;1997.
6. Jacks T, Power MD, Masiarz FR, Luciw PA, Barr PJ, Varmus HE. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature 331:280-283;1988.
7. Kohl NE, Emini EA, Schleif WA, Davis LJ, Heimbach JC, Dixon RA, Scolnick EM, Sigal IS. Active human immunodeficiency virus protease is required for viral infectivity. Proc Natl Acad Sci USA 85:4686-4690;1988.
8. Peng C, Ho BK, Chang TW, Chang NT. Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity. J Virol 63:2550-2556;1989.
9. Prince AM, Reesink H, Pascual D, Horowitz B, Hewlett I, Murthy KK, Cobb KE, Eichberg JW. Prevention of HIV infection by passive immunization with HIV immunoglobulin. AIDS Res Hum Retroviruses 7:971-973;1997.
10. Srinivasakumar N, Hammarskjold ML, Rekosh D. Characterization of deletion mutations in the capsid region of human immunodeficiency virus type 1 that affect particle formation and Gag-Pol precursor incorporation. J Virol. 69:6106-6114;1995.
11. Wills JW, Craven RC. Form, function, and use of retroviral gag proteins. AIDS 5:639-654; 1991.